Search Results - "Bouthillier, Johanne"

Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation by Marceau, François, Bachelard, Hélène, Bouthillier, Johanne, Fortin, Jean-Philippe, Morissette, Guillaume, Bawolak, Marie-Thérèse, Charest-Morin, Xavier, Gera, Lajos

“…•Bradykinin-related peptides stimulate 2 GPCRs, the B1 and B2 receptors (B1R, B2R).•Peptide and non-peptide antagonists and fluorescent ligands are known for…”
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Cation trapping by cellular acidic compartments: Beyond the concept of lysosomotropic drugs by Marceau, François, Bawolak, Marie-Thérèse, Lodge, Robert, Bouthillier, Johanne, Gagné-Henley, Angélique, C.-Gaudreault, René, Morissette, Guillaume

“…“Lysosomotropic” cationic drugs are known to concentrate in acidic cell compartments due to low retro-diffusion of the protonated molecule (ion trapping); they…”
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Autophagic flux inhibition and lysosomogenesis ensuing cellular capture and retention of the cationic drug quinacrine in murine models by Parks, Alexandre, Charest-Morin, Xavier, Boivin-Welch, Michael, Bouthillier, Johanne, Marceau, Francois

“…The proton pump vacuolar (V)-ATPase is the driving force that mediates the concentration of cationic drugs (weak bases) in the late endosome-lysosome…”
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Vacuolar ATPase-Mediated Cellular Concentration and Retention of Quinacrine: A Model for the Distribution of Lipophilic Cationic Drugs to Autophagic Vacuoles by MARCEAU, Françols, BAWOLAK, Marie- Thérèse, BOUTHILLIER, Johanne, MORISSETTE, Guillaume

“…The antiprotozoal agent quinacrine is a lipophilic cationic drug highly distributed to tissues. It has been used in the present experiments to examine whether…”
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A novel nonpeptide antagonist of the kinin B1 receptor: effects at the rabbit receptor by Morissette, Guillaume, Fortin, Jean-Philippe, Otis, Sophie, Bouthillier, Johanne, Marceau, François

“…The kinin B1 receptor (B1R) has attracted interest as a potential therapeutic target because this inducible G protein-coupled receptor is involved in sustained…”
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Endogenous aminopeptidase N decreases the potency of peptide agonists and antagonists of the kinin B1 receptors in the rabbit aorta by Fortin, Jean-Philippe, Gera, Lajos, Bouthillier, Johanne, Stewart, John M, Adam, Albert, Marceau, François

“…The B(1) receptor for kinins is selectively stimulated by bradykinin-related fragments lacking the C-terminal arginine, des-arginine(9)-bradykinin…”
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Fluorescent ligands of the bradykinin B1 receptors: pharmacologic characterization and application to the study of agonist-induced receptor translocation and cell surface receptor expression by Bawolak, Marie-Thérèse, Gera, Lajos, Morissette, Guillaume, Bouthillier, Johanne, Stewart, John M, Gobeil, Lise-Andrée, Lodge, Robert, Adam, Albert, Marceau, François

“…Unlike the widely distributed and preformed B(2) receptors, the bradykinin B(1) receptors exhibit a highly regulated expression and minimal agonist-induced…”
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Absence of ligand‐induced regulation of kinin receptor expression in the rabbit by Sabourin, Thierry, Guay, Katline, Houle, Steeve, Bouthillier, Johanne, Bachvarov, Dimcho R, Adam, Albert, Marceau, François

“…The induction of B1 receptors (B1Rs) and desensitization or down‐regulation of B2 receptors (B2Rs) as a consequence of the production of endogenous kinins has…”
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Pulse exposure to protein synthesis inhibitors enhances vascular responses to des‐Arg9‐bradykinin: possible role of interleukin‐1 by deBlois, Denis, Bouthillier, Johanne, Marceau, François

“…1 The modulation of the spontaneous increase in contractile responses to des‐Arg9‐bradykinin (des‐Arg9‐BK) of rabbit aortic strips incubated in vitro was…”
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Contractile Effect of Anaphylatoxin C5a and of a Mimetic Peptide on the Human Umbilical Artery: Further Evidence for Leukocyte-Dependent Vasomotion by Fortin, Jean-Philippe, Bouthillier, Johanne, St-Pierre, Serge A, Marceau, François

“…Reproducible and concentration-dependent contractile effects were recorded when the human umbilical artery was exposed to recombinant C5a (≥1 n M). The…”
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Inflammatory hyperalgesia induced by zymosan in the plantar tissue of the rat : effect of kinin receptor antagonists by BELICHARD, P, LANDRY, M, FAYE, P, BACHVAROV, D. R, BOUTHILLIER, J, PRUNEAU, D, MARCEAU, F

“…The Randall-Selitto paradigm (maximal tolerated pressure externally applied by a mechanical device) was used to develop a rat model of localized inflammatory…”
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Effects of inactivation‐resistant agonists on the signalling, desensitization and down‐regulation of bradykinin B 2 receptors by Bawolak, Marie‐Thérèse, Fortin, Sébastien, Bouthillier, Johanne, Adam, Albert, Gera, Lajos, C.‐Gaudreault, René, Marceau, François

“…Background and purpose:  A peptide bradykinin (BK) B 2 receptor agonist partially resistant to degradation, B‐9972, down‐regulates this receptor subtype. We…”
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Met-Lys-bradykinin-Ser-Ser, a peptide produced by the neutrophil from kininogen, is metabolically activated by angiotensin converting enzyme in vascular tissue by Gera, Lajos, Roy, Caroline, Bawolak, Marie-Thérèse, Bouthillier, Johanne, Adam, Albert, Marceau, François

“…Bradykinin (BK) is a vasoactive nonapeptide cleaved from circulating kininogens and that is degraded by angiotensin converting enzyme (ACE). It has been…”
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Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase–activated B2 receptor agonists by Charest-Morin, Xavier, Roy, Caroline, Fortin, Émile-Jacques, Bouthillier, Johanne, Marceau, François

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Effects of inactivation‐resistant agonists on the signalling, desensitization and down‐regulation of bradykinin B2 receptors by Bawolak, Marie‐Thérèse, Fortin, Sébastien, Bouthillier, Johanne, Adam, Albert, Gera, Lajos, C.‐Gaudreault, René, Marceau, François

“…Background and purpose:  A peptide bradykinin (BK) B2 receptor agonist partially resistant to degradation, B‐9972, down‐regulates this receptor subtype. We…”
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In vitro modeling of the action of adrenergic decongestant drugs: reservoir formation, toxicity and V‐ATPase‐mediated vacuolar cytopathology by Marceau, Francois, Bouthillier, Johanne, Morissette, Guillaume

“…Concentrated α‐adrenoceptor agonists are often topically applied (decongestants, mydriatics). We examined whether a series of α‐adrenoceptor agonists are taken…”
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Non‐competitive pharmacological antagonism at the rabbit B 1 receptor by Larrivée, Jean‐François, Gera, Lajos, Houle, Steeve, Bouthillier, Johanne, Bachvarov, Dimcho R, Stewart, John M, Marceau, François

“…The B 1 receptor for kinins, stimulated by kinin metabolites without the C‐terminal Arg residue (e.g., des‐Arg 9 ‐bradykinin (BK) and Lys‐des‐Arg 9 ‐BK), is an…”
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Receptor tyrosine kinases as mediators of injury-induced bradykinin B 1 receptor expression in rabbit aortic smooth muscle by Koumbadinga, Gérémy Abdull, Petitclerc, Eric, Bouthillier, Johanne, Adam, Albert, Marceau, François

“…Prolonged in vitro incubation of rabbit aortic rings allows recording contractile responses mediated by the inducible bradykinin B 1 receptors; addition of…”
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Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle by ABDULL KOUMBADINGA, Gérémy, PETITCLERC, Eric, BOUTHILLIER, Johanne, ADAM, Albert, MARCEAU, Francois

“…Prolonged in vitro incubation of rabbit aortic rings allows recording contractile responses mediated by the inducible bradykinin B(1) receptors; addition of…”
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Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: Possible origin of pharmacological distortions and side effects by Morissette, Guillaume, Lodge, Robert, Bouthillier, Johanne, Marceau, François

“…The aims of this study were to investigate whether several histamine receptor agonists and antagonists are subjected to receptor-independent ion trapping into…”
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