Search Results - "Boutarfa, Asma"
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A label‐free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P1 agonists
Published in FEBS open bio (01-10-2020)“…S1P1 activation maintains endothelial barrier integrity, whereas its desensitization induces lymphopenia. SAR247799, a new G protein‐biased S1P1 agonist, was…”
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A label-free impedance assay in endothelial cells differentiates the activation and desensitization properties of clinical S1P 1 agonists
Published in FEBS open bio (01-10-2020)“…Sphingosine-1 phosphate receptor-1 (S1P ) activation maintains endothelial barrier integrity, whereas S1P desensitization induces peripheral blood lymphopenia…”
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Immunosuppressive effects of mesenchymal stem cells : Involvement of HLA-G
Published in Transplantation (27-07-2007)“…Mesenchymal stem cells (MSCs) possess unique immunomodulatory properties. They are able to suppress allogenic T-cell response and modify maturation of…”
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Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model
Published in Annals of hematology (01-01-2007)“…It has been suggested that human mesenchymal stem cells (hMSC) could be used to repair numerous injured tissues. We have studied the potential use of hMSC to…”
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Discovery of SAR184841, a potent and long-lasting inhibitor of 11β-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D
Published in Bioorganic & medicinal chemistry letters (15-04-2013)“…Starting from 11β-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent…”
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Discovery of SAR184841, a potent and long-lasting inhibitor of 11[beta]-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D
Published in Bioorganic & medicinal chemistry letters (15-04-2013)“…Starting from 11[beta]-HSD1 inhibitors that were active ex vivo but with Cyp 3A4 liability, we obtained a new series of adamantane ureas displaying potent…”
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Journal Article