Search Results - "Boussioutas, Alex"

Cross-validation of survival associated biomarkers in gastric cancer using transcriptomic data of 1,065 patients by Szász, A Marcell, Lánczky, András, Nagy, Ádám, Förster, Susann, Hark, Kim, Green, Jeffrey E, Boussioutas, Alex, Busuttil, Rita, Szabó, András, Győrffy, Balázs

“…Multiple gene expression based prognostic biomarkers have been repeatedly identified in gastric carcinoma. However, without confirmation in an independent…”
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Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry by Huang, Yu-Kuan, Wang, Minyu, Sun, Yu, Di Costanzo, Natasha, Mitchell, Catherine, Achuthan, Adrian, Hamilton, John A., Busuttil, Rita A., Boussioutas, Alex

“…Tumor-associated macrophages (TAMs), one of the most abundant immune components in gastric cancer (GC), are difficult to characterize due to their…”
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IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization by Eissmann, Moritz F., Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh R., Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas D., Hibbs, Margaret L., Boussioutas, Alex, Grimbaldeston, Michele A., Buchert, Michael, O’Donoghue, Robert J. J., Masson, Frederick, Ernst, Matthias

“…The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent,…”
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A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets by Deng, Niantao, Goh, Liang Kee, Wang, Hannah, Das, Kakoli, Tao, Jiong, Tan, Iain Beehuat, Zhang, Shenli, Lee, Minghui, Wu, Jeanie, Lim, Kiat Hon, Lei, Zhengdeng, Goh, Glenn, Lim, Qing-Yan, Tan, Angie Lay-Keng, Sin Poh, Dianne Yu, Riahi, Sudep, Bell, Sandra, Shi, Michael M, Linnartz, Ronald, Zhu, Feng, Yeoh, Khay Guan, Toh, Han Chong, Yong, Wei Peng, Cheong, Hyun Cheol, Rha, Sun Young, Boussioutas, Alex, Grabsch, Heike, Rozen, Steve, Tan, Patrick

“…Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most…”
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Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy by Tan, Iain Beehuat, Ivanova, Tatiana, Lim, Kiat Hon, Ong, Chee Wee, Deng, Niantao, Lee, Julian, Tan, Sze Huey, Wu, Jeanie, Lee, Ming Hui, Ooi, Chia Huey, Rha, Sun Young, Wong, Wai Keong, Boussioutas, Alex, Yeoh, Khay Guan, So, Jimmy, Yong, Wei Peng, Tsuburaya, Akira, Grabsch, Heike, Toh, Han Chong, Rozen, Steven, Cheong, Jae Ho, Noh, Sung Hoon, Wan, Wei Kiat, Ajani, Jaffer A, Lee, Ju–Seog, Salto–Tellez, Manuel, Tan, Patrick

“…Background & Aims Gastric cancer (GC) is a heterogeneous disease comprising multiple subtypes that have distinct biological properties and effects in patients…”
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Risk factors for metachronous colorectal cancer and advanced neoplasia following primary colorectal cancer: a systematic review and meta-analysis by Zhang, Ye, Karahalios, Amalia, Aung, Ye Kyaw, Win, Aung Ko, Boussioutas, Alex, Jenkins, Mark A

“…Abstract Background Identifying risk factors for metachronous colorectal cancer (CRC) and metachronous advanced neoplasia could be useful for guiding…”
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An orthotopic mouse model of gastric cancer invasion and metastasis by Busuttil, Rita A., Liu, David S., Di Costanzo, Natasha, Schröder, Jan, Mitchell, Catherine, Boussioutas, Alex

“…Gastric cancer is a leading cause of cancer death worldwide, with advanced stage being correlated to the level of tumour invasion and metastasis. Current…”
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Early relapses after adjuvant chemotherapy suggests primary chemoresistance in diffuse gastric cancer by Pattison, Sharon, Mitchell, Catherine, Lade, Stephen, Leong, Trevor, Busuttil, Rita A, Boussioutas, Alex

“…Survival from gastric cancer remains poor, particularly in Western populations. Previous pre-clinical and subgroup analyses of clinical trials have suggested…”
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The Role of Innate Immune Cells in Tumor Invasion and Metastasis by Huang, Yu-Kuan, Busuttil, Rita A, Boussioutas, Alex

“…Metastasis is considered one of the hallmarks of cancer and enhanced tumor invasion and metastasis is significantly associated with cancer mortality…”
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Oncogenic pathway combinations predict clinical prognosis in gastric cancer by Ooi, Chia Huey, Ivanova, Tatiana, Wu, Jeanie, Lee, Minghui, Tan, Iain Beehuat, Tao, Jiong, Ward, Lindsay, Koo, Jun Hao, Gopalakrishnan, Veena, Zhu, Yansong, Cheng, Lai Ling, Lee, Julian, Rha, Sun Young, Chung, Hyun Cheol, Ganesan, Kumaresan, So, Jimmy, Soo, Khee Chee, Lim, Dennis, Chan, Weng Hoong, Wong, Wai Keong, Bowtell, David, Yeoh, Khay Guan, Grabsch, Heike, Boussioutas, Alex, Tan, Patrick

“…Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major…”
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CD10 and Das1: a biomarker study using immunohistochemistry to subtype gastric intestinal metaplasia by Koulis, Athanasios, Di Costanzo, Natasha, Mitchell, Catherine, Lade, Stephen, Goode, David, Busuttil, Rita A, Boussioutas, Alex

“…Intestinal metaplasia (IM) is considered a key pivot point in the Correa model of gastric cancer (GC). It is histologically subtyped into the complete and…”
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A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response by BUSUTTIL, Rita A, GEORGE, Joshy, TOTHILL, Richard W, IOCULANO, Kylie, KOWALCZYK, Adam, MITCHELL, Catherine, LADE, Stephen, TAN, Patrick, HAVIV, Izhak, BOUSSIOUTAS, Alex

“…Gene-expression profiling has revolutionized the way we think about cancer and confers the ability to observe the synchronous expression of thousands of genes…”
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Intestinal metaplasia: A premalignant lesion involved in gastric carcinogenesis by Busuttil, Rita A, Boussioutas, Alex

“…Despite a plateau in incidence, gastric cancer remains a significant problem globally. The majority of gastric cancer is associated with histologically…”
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SFRP4 drives invasion in gastric cancer and is an early predictor of recurrence by Busuttil, Rita A., George, Joshy, House, Colin M., Lade, Stephen, Mitchell, Catherine, Di Costanzo, Natasha S., Pattison, Sharon, Huang, Yu-Kuan, Tan, Patrick, Cheong, Jae-Ho, Rha, Sun Young, Boussioutas, Alex

“…Objective Gastric cancer patients generally have a poor outcome, particularly those with advanced-stage disease which is defined by the increased invasion of…”
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Immunological battlefield in gastric cancer and role of immunotherapies by Wang, Minyu, Busuttil, Rita A, Pattison, Sharon, Neeson, Paul J, Boussioutas, Alex

“…Like the wars predating the First World War where human foot soldiers were deemed tools in the battlefield against an enemy, so too are the host immune cells…”
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mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice by Thiem, Stefan, Pierce, Thomas P, Palmieri, Michelle, Putoczki, Tracy L, Buchert, Michael, Preaudet, Adele, Farid, Ryan O, Love, Chris, Catimel, Bruno, Lei, Zhengdeng, Rozen, Steve, Gopalakrishnan, Veena, Schaper, Fred, Hallek, Michael, Boussioutas, Alex, Tan, Patrick, Jarnicki, Andrew, Ernst, Matthias

“…Gastrointestinal cancers are frequently associated with chronic inflammation and excessive secretion of IL-6 family cytokines, which promote tumorigenesis…”
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Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within interleukin-6 family cytokines by Huber, Anne, Allam, Amr H., Dijkstra, Christine, Thiem, Stefan, Huynh, Jennifer, Poh, Ashleigh R., Konecnik, Joshua, Jacob, Saumya P., Busuttil, Rita, Liao, Yang, Chisanga, David, Shi, Wei, Alorro, Mariah G., Forrow, Stephen, Tauriello, Daniele V.F., Batlle, Eduard, Boussioutas, Alex, Williams, David S., Buchert, Michael, Ernst, Matthias, Eissmann, Moritz F.

“…Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the…”
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Risk of Metachronous Colon Cancer Following Surgery for Rectal Cancer in Mismatch Repair Gene Mutation Carriers by Win, Aung Ko, Parry, Susan, Parry, Bryan, Kalady, Matthew F., Macrae, Finlay A., Ahnen, Dennis J., Young, Graeme P., Lipton, Lara, Winship, Ingrid, Boussioutas, Alex, Young, Joanne P., Buchanan, Daniel D., Arnold, Julie, Le Marchand, Loïc, Newcomb, Polly A., Haile, Robert W., Lindor, Noralane M., Gallinger, Steven, Hopper, John L., Jenkins, Mark A.

“…Background Despite regular surveillance colonoscopy, the metachronous colorectal cancer risk for mismatch repair (MMR) gene mutation carriers after segmental…”
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Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer by Humphries, Julia M., Penno, Megan A.S., Weiland, Florian, Klingler-Hoffmann, Manuela, Zuber, Agnieszka, Boussioutas, Alex, Ernst, Matthias, Hoffmann, Peter

“…The timely detection of gastric cancer will contribute significantly towards effective treatment and is aided by the availability and reliability of…”
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Role of p53 in the progression of gastric cancer by Busuttil, Rita A, Zapparoli, Giada V, Haupt, Sue, Fennell, Christina, Wong, Stephen Q, Pang, Jia-Min B, Takeno, Elena A, Mitchell, Catherine, Di Costanzo, Natasha, Fox, Stephen, Haupt, Ygal, Dobrovic, Alexander, Boussioutas, Alex

“…Intestinal metaplasia (IM) is a premalignant lesion associated with gastric cancer (GC) but is poorly described in terms of molecular changes. Here, we…”
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