Search Results - "Boussiotis, V"

Double umbilical cord blood transplantation with reduced intensity conditioning and sirolimus-based GVHD prophylaxis by Cutler, C, Stevenson, K, Kim, H T, Brown, J, McDonough, S, Herrera, M, Reynolds, C, Liney, D, Kao, G, Ho, V, Armand, P, Koreth, J, Alyea, E, Dey, B R, Attar, E, Spitzer, T, Boussiotis, V A, Ritz, J, Soiffer, R, Antin, J H, Ballen, K

“…The main limitations to umbilical cord blood (UCB) transplantation (UCBT) in adults are delayed engraftment, poor immunological reconstitution and high rates…”
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Mouse Inducible Costimulatory Molecule (ICOS) Expression Is Enhanced by CD28 Costimulation and Regulates Differentiation of CD4+ T Cells by McAdam, Alexander J, Chang, Tammy T, Lumelsky, Anna E, Greenfield, Edward A, Boussiotis, Vassiliki A, Duke-Cohan, Jonathan S, Chernova, Tatyana, Malenkovich, Nelly, Jabs, Claudia, Kuchroo, Vijay K, Ling, Vincent, Collins, Mary, Sharpe, Arlene H, Freeman, Gordon J

“…The inducible costimulatory (ICOS) molecule is expressed by activated T cells and has homology to CD28 and CD152. ICOS binds B7h, a molecule expressed by APC…”
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Transplantation of Anergic Histoincompatible Bone Marrow Allografts by Guinan, Eva C, Boussiotis, Vassiliki A, Neuberg, Donna, Brennan, Lisa LaVita, Hirano, Naoto, Nadler, Lee M, Gribben, John G

“…Successful transplantation of organs requires the use of agents capable of suppressing the immune response against alloantigens. 1 – 3 Use of these nonspecific…”
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Maintenance of human T cell anergy : Blocking of IL-2 gene transcription by activated Rap1 by BOUSSIOTIS, V. A, FREEMAN, G. J, BEREZOVSKAYA, A, BARBER, D. L, NADLER, L. M

“…In the absence of costimulation, T cells activated through their antigen receptor become unresponsive (anergic) and do not transcribe the gene encoding…”
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T cell anergy and costimulation by Appleman, Leonard J., Boussiotis, Vassiliki A.

“…T lymphocytes play a key role in immunity by distinguishing self from nonself peptide antigens and regulating both the cellular and humoral arms of the immune…”
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Immunomodulatory effects of vitamin D: implications for GVHD by Rosenblatt, J, Bissonnette, A, Ahmad, R, Wu, Z, Vasir, B, Stevenson, K, Zarwan, C, Keefe, W, Glotzbecker, B, Mills, H, Joyce, R, Levine, J D, Tzachanis, D, Boussiotis, V, Kufe, D, Avigan, D

“…GVHD remains a major source of morbidity and mortality after allogeneic BMT. GVHD is mediated by alloreactive T cells derived from the hematopoietic graft that…”
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Prostaglandin E2 promotes survival of naive UCB T cells via the Wnt/β-catenin pathway and alters immune reconstitution after UCBT by Li, L, Kim, H T, Nellore, A, Patsoukis, N, Petkova, V, McDonough, S, Politikos, I, Nikiforow, S, Soiffer, R, Antin, J H, Ballen, K, Cutler, C, Ritz, J, Boussiotis, V A

“…The outcome of umbilical cord blood transplantation (UCBT) is compromised by low hematopoietic stem cell (HSC) doses leading to prolonged time to engraftment,…”
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Prevention of T Cell Anergy by Signaling Through the $\gamma_c$ Chain of the IL-2 Receptor by Boussiotis, Vassiliki A., Barber, Dwayne L., Nakarai, Takayuki, Freeman, Gordon J., Gribben, John G., Bernstein, Gregory M., D'Andrea, Alan D., Ritz, Jerome, Nadler, Lee M.

“…When stimulated through their antigen receptor without requisite costimulation, T cells enter a state of antigen-specific unresponsiveness, termed anergy. In…”
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Pivotal Role of the B7:CD28 Pathway in Transplantation Tolerance and Tumor Immunity by Guinan, Eva C., Gribben, John G., Boussiotis, Vicki A., Freeman, Gordon J., Nadler, Lee M.

“…The above story illustrates the translation of basic scientific discoveries to the clinic. In vitro and preclinical in vivo experimentation suggests that…”
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Cloning of B7-2: A CTLA-4 Counter-Receptor that Costimulates Human T Cell Proliferation by Freeman, Gordon J., Gribben, John G., Boussiotis, Vassiliki A., Ng, Judy W., Restivo, Vincent A., Lombard, Lisa A., Gray, Gary S., Nadler, Lee M.

“…Although presentation of antigen to the T cell receptor is necessary for the initiation of an immune response, additional molecules expressed on…”
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Interleukin-4 stimulates proliferation and growth of T-cell acute lymphoblastic leukemia cells by activating mTOR signaling by Cardoso, B A, Martins, L R, Santos, C I, Nadler, L M, Boussiotis, V A, Cardoso, A A, Barata, J T

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Human CD100, a Novel Leukocyte Semaphorin that Promotes B-Cell Aggregation and Differentiation by Hall, Kathryn T., Boumsell, Laurence, Schultze, Joachim L., Boussiotis, Vassiliki A., Dorfman, David M., Cardoso, Angelo A., Bensussan, Armand, Nadler, Lee M., Freeman, Gordon J.

“…Herein we describe the molecular characterization of the human leukocyte activation antigen CD100 and identify it as the first semaphorin, to our knowledge, in…”
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Control and regulation of peripheral tolerance in allergic inflammatory disease: therapeutic consequences by Li, L, Boussiotis, V

“…During the past few years there has been significant pro - gress in understanding the mechanisms by which abnormal T-cell responses are generated in allergic…”
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CTLA4 Mediates Antigen-Specific Apoptosis of Human T Cells by Gribben, John G., Freeman, Gordon J., Boussiotis, Vassiliki A., Rennert, Paul, Jellis, Cindy L., Greenfield, Edward, Barber, Michael, Restivo, Vincent A., Ke, Xiaoyan, Gray, Gary S., Nadler, Lee M.

“…The regulation of T cell-mediated immune responses requires a balance between amplification and generation of effector function and subsequent selective…”
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IL-10-producing T cells suppress immune responses in anergic tuberculosis patients by Boussiotis, V A, Tsai, E Y, Yunis, E J, Thim, S, Delgado, J C, Dascher, C C, Berezovskaya, A, Rousset, D, Reynes, J M, Goldfeld, A E

“…The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms and is linked to inadequate immune response of the host. Containment…”
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Pre-B acute lymphoblastic leukemia cells may induce T-cell anergy to alloantigen by CARDOSO, A. A, SCHULTZE, J. L, BOUSSIOTIS, V. A, FREEMAN, G. J, SEAMON, M. J, LASZLO, S, BILLET, A, SALLAN, S. E, GRIBBEN, J. G, NADLER, L. M

“…Even if neoplastic cells express tumor associated antigens they still may fail to function as antigen presenting cells (APC) if they lack expression of one or…”
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Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells by Boussiotis, Vassiliki A, Tzachanis, Dimitrios, Freeman, Gordon J, Hirano, Naoto, van Puijenbroek, Andre A. F. L, Delfs, Michael W, Berezovskaya, Alla, Nadler, Lee M

“…During a search for genes that maintain T cell quiescence, we determined that Tob, a member of an anti-proliferative gene family, was highly expressed in…”
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The role of B7-1/B7-2:CD28/CLTA-4 pathways in the prevention of anergy, induction of productive immunity and down-regulation of the immune response by Boussiotis, V A, Freeman, G J, Gribben, J G, Nadler, L M

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B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance by BOUSSIOTIS, V. A, FREEMAN, G. J, GRAY, G, GRIBBEN, J, NADLER, L. M

“…Presentation of antigen by the major histocompatibility complex to T lymphocytes without the requisite costimulatory signals does not induce an immune response…”
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Activated human B lymphocytes express three CTLA-4 counterreceptors that costimulate T-cell activation by BOUSSIOTIS, V. A, FREEMAN, G. J, GRIBBEN, J. G, DALEY, J, GRAY, G, NADLER, L. M

“…Signaling via the T-cell receptor complex is necessary but not sufficient to induce antigen-specific T lymphocytes to expand clonally. To proliferate, T cells…”
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