Search Results - "Boussetta, Tarek"

The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils by Raad, Houssam, Mouawia, Hussein, Hassan, Hamad, El-Seblani, Mohamed, Arabi-Derkawi, Riad, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

“…Superoxide anion production by neutrophils is essential for host defense against microbes. Superoxide anion generates other reactive oxygen species (ROS) that…”
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Protectin DX, a Double Lipoxygenase Product of DHA, Inhibits Both ROS Production in Human Neutrophils and Cyclooxygenase Activities by Liu, Miao, Boussetta, Tarek, Makni-Maalej, Karama, Fay, Michèle, Driss, Fathi, El-Benna, Jamel, Lagarde, Michel, Guichardant, Michel

“…Neutrophils play a major role in inflammation by releasing large amounts of reactive oxygen species (ROS) produced by NADPH oxidase (NOX) and myeloperoxidase…”
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The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1 by Makni-Maalej, Karama, Boussetta, Tarek, Hurtado-Nedelec, Margarita, Belambri, Sahra Amel, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

“…Superoxide anion production by the neutrophil NADPH oxidase plays a key role in host defense; however, excessive superoxide production is believed to…”
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Increased reactive oxygen species production and p47phox phosphorylation in neutrophils from myeloproliferative disorders patients with JAK2 (V617F) mutation by Hurtado-Nedelec, Margarita, Csillag-Grange, Marie-José, Boussetta, Tarek, Belambri, Sahra Amel, Fay, Michèle, Cassinat, Bruno, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

“…Myeloproliferative disorders are associated with increased risk of thrombosis and vascular complications. The pathogenesis of these complications is not…”
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Prolyl-Isomerase Pin1 Controls Key fMLP-Induced Neutrophil Functions by Bedouhene, Samia, Liu, Min, Senani, Nassima, Boussetta, Tarek, Pintard, Coralie, Dang, Pham My-Chan, El-Benna, Jamel

“…Neutrophils are key cells of the innate immune and inflammatory responses. They are the first blood cells to migrate to the infection site where they release…”
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Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox by Raad, Houssam, Paclet, Marie-Hélène, Boussetta, Tarek, Kroviarski, Yolande, Morel, Françoise, Quinn, Mark T, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

“…Neutrophils generate microbicidal oxidants through activation of a multicomponent enzyme called NADPH oxidase. During activation, the cytosolic NADPH oxidase…”
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The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites by Boussetta, Tarek, Raad, Houssam, Bedouhene, Samia, Arabi Derkawi, Riad, Gougerot-Pocidalo, Marie-Anne, Hayem, Gilles, Dang, Pham My-Chan, El-Benna, Jamel

“…•GM-CSF induced the activation of the prolyl cis/trans isomerase Pin1 in human neutrophils.•Juglone and PiB, two Pin1 inhibitors dampens GM-CSF-induced priming…”
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An aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice by Bachoual, Rafik, Talmoudi, Wifak, Boussetta, Tarek, Braut, Françoise, El-Benna, Jamel

“…Punica granatum peel aqueous extract (PGE) is widely used to treat disorders such as inflammation, ulcers and infections, but its pharmacological target is not…”
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Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease by Belambri, Sahra Amel, Marzaioli, Viviana, Hurtado-Nedelec, Margarita, Pintard, Coralie, Liang, Shiyu, Liu, Yezhou, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Ye, Richard D., Dang, Pham My-Chan, El-Benna, Jamel

“…Superoxide production by the phagocyte reduced NAD phosphate (NADPH) oxidase is essential for innate immunity as shown in chronic granulomatous disease (CGD),…”
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Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats by Boussetta, Tarek, Raad, Houssam, Lettéron, Philippe, Gougerot-Pocidalo, Marie-Anne, Marie, Jean-Claude, Driss, Fathi, El-Benna, Jamel

“…Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO). The proinflammatory…”
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Impaired p47phox phosphorylation in neutrophils from p67phox-deficient chronic granulomatous disease patients Short title: p67phox regulates p47phox phosphorylation by Belambri, Sahra Amel, Marzaioli, Viviana, Hurtado-Nedelec, Margarita, Pintard, Coralie, Liang, Shiyu, Liu, Yezhou, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Ye, Richard, Dang, Pham My-Chan, El-Benna, Jamel

“…Abstract Superoxide production by the phagocyte reduced NAD phosphate (NADPH) oxidase is essential for innate immunity as shown in chronic granulomatous…”
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The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils by Raad, Houssam, Mouawia, Hussein, Hassan, Hamad, El-Seblani, Mohamed, Arabi-Derkawi, Riad, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

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Shifting FcγRIIA-ITAM from activation to inhibitory configuration ameliorates arthritis by Ben Mkaddem, Sanae, Hayem, Gilles, Jönsson, Friederike, Rossato, Elisabetta, Boedec, Erwan, Boussetta, Tarek, El Benna, Jamel, Launay, Pierre, Goujon, Jean-Michel, Benhamou, Marc, Bruhns, Pierre, Monteiro, Renato C

“…Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune…”
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IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses by Aloulou, Meryem, Ben Mkaddem, Sanae, Biarnes-Pelicot, Martine, Boussetta, Tarek, Souchet, Hervé, Rossato, Elisabetta, Benhamou, Marc, Crestani, Bruno, Zhu, Zhou, Blank, Ulrich, Launay, Pierre, Monteiro, Renato C.

“…Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune and inflammatory diseases. However, its mechanism of action remains…”
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Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats by Boussetta, Tarek, Raad, Houssam, Lettéron, Philippe, Gougerot-Pocidalo, Marie-Anne, Marie, Jean-Claude, Driss, Fathi, El-Benna, Jamel

“…Background Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO). The…”
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The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes by Arabi-Derkawi, Riad, O’dowd, Yvonne, Cheng, Ni, Rolas, Loïc, Boussetta, Tarek, Raad, Houssam, Marzaioli, Viviana, Pintard, Coralie, Fasseu, Magali, Kroviarski, Yolande, Belambri, Sahra A, Dang, Pham My-Chan, Ye, Richard D, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

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The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α–induced priming of the NADPH oxidase in human neutrophils by Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Hayem, Gilles, Ciappelloni, Silvia, Raad, Houssam, Arabi Derkawi, Riad, Bournier, Odile, Kroviarski, Yolande, Zhou, Xiao Zhen, Malter, James S., Lu, Ping K., Bartegi, Aghleb, Dang, Pham My-Chan, El-Benna, Jamel

“…Neutrophils play a key role in host defense by releasing reactive oxygen species (ROS). However, excessive ROS production by neutrophil nicotinamide adenine…”
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The Kinesin Light Chain-Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes by Arabi-Derkawi, Riad, O'Dowd, Yvonne, Cheng, Ni, Rolas, Loïc, Boussetta, Tarek, Raad, Houssam, Marzaioli, Viviana, Pintard, Coralie, Fasseu, Magali, Kroviarski, Yolande, Belambri, Sahra A, Dang, Pham My-Chan, Ye, Richard D, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

“…Superoxide anion production by the phagocyte NADPH oxidase plays a crucial role in host defenses and inflammatory reaction. The phagocyte NADPH oxidase is…”
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TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils by Makni‐Maalej, Karama, Marzaioli, Viviana, Boussetta, Tarek, Belambri, Sahra Amel, Gougerot‐Pocidalo, Marie‐Anne, Hurtado‐Nedelec, Margarita, Dang, Pham My‐Chan, El‐Benna, Jamel

“…TLR‐8 primes PMN ROS by inducing the phosphorylation of p47phox and p38MAPKinase, while also involving Pin1. Neutrophils play a key role in host defense…”
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Shifting Fc[gamma]RIIA-ITAM from activation to inhibitory configuration ameliorates arthritis by Mkaddem, Sanae Ben, Hayem, Gilles, Jönsson, Friederike, Rossato, Elisabetta, Boedec, Erwan, Boussetta, Tarek, El Benna, Jamel, Launay, Pierre, Goujon, Jean-Michel, Benhamou, Marc, Bruhns, Pierre, Monteiro, Renato C

“…Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune…”
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