Search Results - "Bousley, Richard F"

Heterocyclic Ureas:  Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase as Hypocholesterolemic Agents by White, Andrew D, Creswell, Mark W, Chucholowski, Alexander W, Blankley, C. John, Wilson, Michael W, Bousley, Richard F, Essenburg, Arnold D, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L, Dominick, Mark A, Neub, Martin

“…A series of diaryl-substituted heterocyclic ureas was prepared, and their ability to inhibit acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and to…”
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Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel .beta.-keto amides as hypocholesterolemic agents by Augelli-Szafran, Corinne E, Blankley, C. John, Roth, Bruce D, Trivedi, Bharat K, Bousley, Richard F, Essenburg, Arnold D, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L

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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 17. Structure−Activity Relationships of Several Series of Compounds Derived from N-Chlorosulfonyl Isocyanate by Picard, Joseph A, O'Brien, Patrick M, Sliskovic, Drago R, Anderson, Maureen K, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Stanfield, Richard L

“…Several series of acyl-CoA:cholesterol O-acyltransferase inhibitors were prepared by the stepwise addition of nitrogen, oxygen, and sulfur nucleophiles to…”
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CI-1011 lowers lipoprotein(a) and plasma cholesterol concentrations in chow-fed cynomolgus monkeys by Ramharack, Randy, Spahr, Mark A, Sekerke, Catherine S, Stanfield, Richard L, Bousley, Richard F, Lee, Helen T, Krause, Brian K

“…Lipoprotein(a) (Lp(a)), which is generated through the covalent association of apolipoprotein(a) (apo(a)) and apo B-100-LDL, is an independent risk factor for…”
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Inhibitors of Acyl-CoA:Cholesterol Acyltransferase (ACAT). 7. Development of a Series of Substituted N-Phenyl-N'-[(1-phenylcyclopentyl)methyl]ureas with Enhanced Hypocholesterolemic Activity by Trivedi, Bharat K, Purchase, Terri Stoeber, Holmes, Ann, Augelli-Szafran, Corinne E, Essenburg, Arnold D, Hamelehle, Katherine L, Stanfield, Richard L, Bousley, Richard F, Krause, Brian R

“…We recently described our initial structure-activity relationship (SAR) studies on a series of N-phenyl-N'-aralkyl- and N-phenyl-N'-(1-phenylcycloalkyl)ureas…”
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α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity by Sliskovic, Drago R, Picard, Joseph A, O'Brien, Patrick M, Liao, Peggy, Roark, W. Howard, Roth, Bruce D, Anderson, Maureen A, Mueller, Sandra Bak, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Reindel, James F, Stanfield, Richard L, Turluck, Daniel, Krause, Brian R

“…We prepared a series of α-substituted malonester amides that were evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in…”
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Effect of the ACAT inhibitor CI-976 on plasma cholesterol concentrations and distribution in hamsters fed zero- and low-cholesterol diets by Krause, B R, Bousley, R F, Kieft, K A, Stanfield, R L

“…The overall objective of the present study was to determine if the ACAT inhibitor CI-976 can lower plasma cholesterol in hamsters fed zero or low, "human-like"…”
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Antithrombotic effect of LB-30057 (CI-1028), a new synthetic thrombin inhibitor, in a rabbit model of thrombosis: Comparison with inogatran by LIGUO CHI, MERTZ, Thomas E, ROGERS, Karen L, JANICZEK, Nancy, PENG, Yun-Wen, SAGANEK, Lori, BOUSLEY, Richard F, JUNEAU, Paul L, UPRICHARD, Andrew C. G, GALLAGHER, Kim P

“…LB-30057 (CI-1028) is a novel, orally bioavailable, direct thrombin inhibitor with a Ki of 0.38 nM against human thrombin. The effects of LB-30057 on thrombus…”
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Heterocyclic Amides:  Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase with Hypocholesterolemic Activity in Several Species and Antiatherosclerotic Activity in the Rabbit by White, Andrew D, Purchase, Claude F, Picard, Joseph A, Anderson, Maureen K, Bak Mueller, Sandra, Bocan, Thomas M. A, Bousley, Richard F, Hamelehle, Katherine L, Krause, Brian R, Lee, Peter, Stanfield, Richard L, Reindel, James F

“…A series of heterocyclic amides were synthesized and evaluated as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) in vitro and for cholesterol…”
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Tetrazole-substituted ureas as inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT). A novel preparation of ureas from weakly nucleophilic amines by Purchase, Claude F, White, Andrew D, Anderson, Maureen K, Bocan, Thomas M.A, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Krause, Brian R, Lee, Peter, Mueller, Sandra Bak, Speyer, Cecilia, Stanfield, Richard L, Reindel, James F

“…A novel series of tetrazole-substituted ureas 2 were prepared from weakly nucleophilic amines using a new coupling method. The ureas were found to potently…”
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Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 11. Structure-Activity Relationships of Several Series of Compounds Derived from N-(Chlorocarbonyl) Isocyanate by Picard, Joseph A, Bousley, Richard F, Lee, Helen T, Hamelehle, Katherine L, Krause, Brian R, Minton, Laura L, Sliskovic, Drago R, Stanfield, Richard L

“…Five series of compounds (4-9) derived from N-(chlorocarbonyl) isocyanate have been synthesized and evaluated for their ability to inhibit the enzyme…”
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Inhibitors of Acyl-CoA:cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents.6.The First Water-Soluble ACAT Inhibitor with Lipid-Regulating Activity by Sliskovic, Drago R, Krause, Brian R, Picard, Joseph A, Anderson, Maureen, Bousley, Richard F, Hamelehle, Katherine L, Homan, Reynold, Julian, Thomas N, Rashidbaigi, Zara A, Stanfield, Richard L

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Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. CI-1011:  An Acyl Sulfamate with Unique Cholesterol-Lowering Activity in Animals Fed Noncholesterol-Supplemented Diets by Lee, Helen T., Sliskovic, Drago R., Picard, Joseph A., Roth, Bruce D., Wierenga, Wendell, Hicks, James L., Bousley, Richard F., Hamelehle, Katherine L., Homan, Reynold, Speyer, Cecilia, Stanfield, Richard L., Krause, Brian R.

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Inhibitors of acyl-CoA: cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 6. The first water-soluble ACAT inhibitor with lipid-regulating activity by Sliskovic, D R, Krause, B R, Picard, J A, Anderson, M, Bousley, R F, Hamelehle, K L, Homan, R, Julian, T N, Rashidbaigi, Z A, Stanfield, R L

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Effects of Quinapril, a New Angiotensin Converting Enzyme Inhibitor, on Left Ventricular Failure and Survival in the Cardiomyopathic Hamster: Hemodynamic, Morphological, and Biochemical Correlates by Haleen, Stephen J, Weishaar, Ronald E, Overhiser, Ronald W, Bousley, Richard F, Keiser, Joan A, Rapundalo, Stephen R, Taylor, David G

“…The effect of chronic therapy with quinapril on the temporal progression of left ventricular failure and survival was assessed in the CHF 146 cardiomyopathic…”
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Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 13. Design, synthesis and biological evaluation of tetrazole anilides as potent inhibitors of ACAT in vitro and hypocholesterolemic agents in vivo by O'Brien, Patrick M., Sliskovic, Drago R., Bernabei, Adele, Hurley, Timothy, Anderson, Maureen K., Bousley, Richard F., Krause, Brian R., Stanfield, Richard L.

“…The syntheses and biological activities for anilides derived from 2-phenyl-2-(dodecyl-2H-tetrazol-5-yl)acetic acid are described. Evidence is provided that one…”
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Inhibitors of acyl-CoA:cholesterol acyltransferase. 5. Identification and structure-activity relationships of novel beta-ketoamides as hypocholesterolemic agents by Augelli-Szafran, C E, Blankley, C J, Roth, B D, Trivedi, B K, Bousley, R F, Essenburg, A D, Hamelehle, K L, Krause, B R, Stanfield, R L

“…A study of structure-activity relationships of substituted beta-ketoamide ACAT inhibitors I and II was performed. The results of this study suggest that…”
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Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo by Roth, Bruce D., Howard Roark, W., Picard, Joseph A., Stanfield, Richard L., Bousley, Richard F., Anderson, Maureen K., Hamelehle, Katherine L., Homan, Reynold, Krause, Brian R.

“…A series of sulfonylureas were prepared and tested for the ability to inhibit the enzyme acyl-CoA: cholesterol acyltransferase (ACAT) in vitro and lower plasma…”
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Inhibitors of acyl-CoA: Cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 12. Syntheses and biological activity of structurally novel tetrazole amides by O'Brien, Patrick M., Sliskovic, Drago R., Anderson, Maureen K., Bousley, Richard F., Krause, Brian R., Stanfield, Richard L.

“…The identification of tetrazole benzamide and nicotinamide derivatives as new structural classes of potent ACAT inhibitors is described. The ensuing…”
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Bioisosterism in drug design: Identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors by Howard Roark, W., Padia, Janak, Bolton, Gary L., John Blankley, C., Essenburg, Arnold D., Stanfield, Richard L., Bousley, Richard F., Krause, Brian R., Roth, Bruce D.

“…To examine the effects of bioisosteric replacement on the biological activity of our previously disclosed disubstituted urea inhibitors of the enzyme…”
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