Search Results - "Boushey, H."

A new perspective on concepts of asthma severity and control by Taylor, D. R, Bateman, E. D, Boulet, L-P, Boushey, H. A, Busse, W. W, Casale, T. B, Chanez, P, Enright, P. L, Gibson, P. G, de Jongste, J. C, Kerstjens, H. A. M, Lazarus, S. C, Levy, M. L, O'Byrne, P. M, Partridge, M. R, Pavord, I. D, Sears, M. R, Sterk, P. J, Stoloff, S. W, Szefler, S. J, Sullivan, S. D, Thomas, M. D, Wenzel, S. E, Reddel, H. K

“…Concepts of asthma severity and control are important in the evaluation of patients and their response to treatment but the terminology is not standardised and…”
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Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation by Fonseca, W, Lucey, K, Jang, S, Fujimura, K E, Rasky, A, Ting, H-A, Petersen, J, Johnson, C C, Boushey, H A, Zoratti, E, Ownby, D R, Levine, A M, Bobbit, K R, Lynch, S V, Lukacs, N W

“…Regulation of respiratory mucosal immunity by microbial-derived metabolites has been a proposed mechanism that may provide airway protection. Here we examine…”
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Corticosteroid and long‐acting ß‐agonist therapy reduces epithelial goblet cell metaplasia by Lachowicz‐Scroggins, M. E., Finkbeiner, W. E., Gordon, E. D., Yuan, S., Zlock, L., Bhakta, N. R., Woodruff, P. G., Fahy, J. V., Boushey, H. A.

“…Summary Background Bronchial epithelial goblet cell metaplasia (GCM) with hyperplasia is a prominent feature of asthma, but the effects of treatment with…”
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HLA-DQ strikes again: Genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults by Lasky-Su, J., Himes, B. E., Raby, B. A., Klanderman, B. J., Sylvia, J. Senter, Lange, C., Melen, E., Martinez, F. D., Israel, E., Gauderman, J., Gilliland, F., Sleiman, P., Hakonarson, H., Celedón, J. C., Soto-Quiros, M., Avila, L., Lima, J. J., Irvin, C. G., Peters, S. P., Boushey, H., Chinchilli, V. M., Mauger, D., Tantisira, K., Weiss, S. T.

“…Summary Background Asthma is a common chronic respiratory disease in children and adults. An important genetic component to asthma susceptibility has long been…”
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Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma by Wang, Y, Tong, C, Wang, Z, Wang, Z, Mauger, D, Tantisira, K G, Israel, E, Szefler, S J, Chinchilli, V M, Boushey, H A, Lazarus, S C, Lemanske, R F, Wu, R

“…Asthma is a chronic lung disease that has a high prevalence. The therapeutic intervention of this disease can be made more effective if genetic variability in…”
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Resistance of differentiated human airway epithelium to infection by rhinovirus by Lopez-Souza, N, Dolganov, G, Dubin, R, Sachs, L A, Sassina, L, Sporer, H, Yagi, S, Schnurr, D, Boushey, H A, Widdicombe, J H

“…Virtually all in vitro studies of the effects of rhinovirus on human airway epithelium have used cells grown under conditions known to produce low levels of…”
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The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects by Fahy, J V, Fleming, H E, Wong, H H, Liu, J T, Su, J Q, Reimann, J, Fick, Jr, R B, Boushey, H A

“…A humanized murine monoclonal antibody directed to the Fc epsilonR1-binding domain of human IgE (rhuMAb-E25) has been shown to inhibit the binding of IgE to…”
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Predicting worsening asthma control following the common cold by Walter, M. J, Castro, M, Kunselman, S. J, Chinchilli, V. M, Reno, M, Ramkumar, T. P, Avila, P. C, Boushey, H. A, Ameredes, B. T, Bleecker, E. R, Calhoun, W. J, Cherniack, R. M, Craig, T. J, Denlinger, L. C, Israel, E, Fahy, J. V, Jarjour, N. N, Kraft, M, Lazarus, S. C, Lemanske, R. F., Jr, Martin, R. J, Peters, S. P, Ramsdell, J. W, Sorkness, C. A, Sutherland, E. R, Szefler, S. J, Wasserman, S. I, Wechsler, M. E, National Heart, Lung and Blood Institute's Asthma Clinical Research Network

“…The asthmatic response to the common cold is highly variable, and early characteristics that predict worsening of asthma control following a cold have not been…”
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Prominent neutrophilic inflammation in sputum from subjects with asthma exacerbation by Fahy a, b, John V., Kim b, Kwang Woo, Liu b, Jane, Boushey a, b, Homer A.

“…To infer possible mechanisms of acute airway inflammation and mucus hypersecretion in acute severe asthma, we performed cellular and biochemical analysis on…”
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Effect of a single dose of the selectin inhibitor TBC1269 on early and late asthmatic responses by Avila, P. C., Boushey, H. A., Wong, H., Grundland, H., Liu, J., Fahy, J. V.

“…Summary Background Selectins participate in the initial phase of leucocyte migration from circulation to inflamed tissues and may play a role in inflammatory…”
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Experiences with monoclonal antibody therapy for allergic asthma by Boushey, Homer A.

“…Identification of the central role IgE plays in the pathogenesis of allergic diseases made it a key target for therapy. The first selective anti-IgE therapy, a…”
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Characteristics of patients with seasonal allergic rhinitis and concomitant asthma by Bousquet, J., Boushey, H. A., Busse, W. W., Canonica, G. W., Durham, S. R., Irvin, C. G., Karpel, J. P., Van Cauwenberge, P., Chen, R., Iezzoni, D. G., Harris, A. G.

“…Summary Background Allergic rhinitis and asthma often co‐exist and appear to produce a continuum of airway disease, but whether the clinical characteristics of…”
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Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects by Fahy, J V, Wong, H, Liu, J, Boushey, H A

“…To compare markers of inflammation in secretions obtained by sputum induction (SI), bronchial wash (50 ml instillate [BW]), and bronchoalveolar lavage (4 x 60…”
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Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study by FAHY, John V, BOUSHEY, Homer A, ISRAEL, Elliot, KRAFT, Monica, LEMANSKE, Robert F, MARTIN, Richard J, MCLEAN, Diane, PETERS, Stephen P, SORKNESS, Christine, SZEFLER, Stanley J, LAZARUS, Stephen C, MAUGER, Elizabeth A, CHERNIACK, Reuben M, CHINCHILLI, Vernon M, CRAIG, Timothy J, DRAZEN, Jeffrey M, FORD, Jean G, FISH, James E

“…The safety of sputum induction and the reproducibility of measurements in induced sputum in multicenter studies is unknown. We examined the safety of sputum…”
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Airway Cytokine Pattern Predicts Severity of Asthma Symptoms During Colds by Sabin, B.R, Sabin, A.T, McErlean, P, Ward, T, Liu, J, Boushey, H, Avila, P

“…Patients with asthma (A), allergic rhinitis (AR), or neither (N) with naturally acquired viral RTIs had induced sputum collected as well as upper and lower…”
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Viperin Antiviral Response in Upper Airways is Similar in Asthmatic and Healthy Subjects by Quraishi, J, Greiman, A, Tang, M, Shen, J, Boushey, H, Avila, P, Favoreto, S

“…RT-PCR was used to assess viperin expression and HRV load in vivo in nasal mucosa of subjects with natural HRV colds (n=15); and in vitro in HRV-infected nasal…”
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Ethnic differences: word descriptors used by African-American and white asthma patients during induced bronchoconstriction by Hardie, G E, Janson, S, Gold, W M, Carrieri-Kohlman, V, Boushey, H A

“…To determine if African-American and white patients with asthma (1) differ in the words they use to describe their breathlessness, and (2) differ in their…”
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Rhinovirus-16 Colds in Healthy and in Asthmatic Subjects . Similar Changes in Upper and Lower Airways by FLEMING, H. EDWARD, LITTLE, FREDERIC F, SCHNURR, DAVID, AVILA, PEDRO C, WONG, HOFER, LIU, JANE, YAGI, SHIGEO, BOUSHEY, HOMER A

“…Rhinovirus (RV) infections appear to precipitate most asthma exacerbations. To investigate whether RV-16 induces different inflammatory changes in upper and…”
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Elevation Of Sputum Plasminogen Activator Inhibitor-1 Levels In The Subjects With Asthma by Habib, A, Kim, I, Lee, S, Boushey, H, Ward, T, Liu, J, Schleimer, R.P, Avila, P, Cho, S.H

“…Sputum PAI-1 levels were significantly higher in subjects with asthma than in normal controls, but did not change significantly during acute respiratory viral…”
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Effects of allergic inflammation of the nasal mucosa on the severity of rhinovirus 16 cold by Avila, Pedro C., Abisheganaden, John A., Wong, Hofer, Liu, Jane, Yagi, Shigeo, Schnurr, David, Kishiyama, Jeffrey L., Boushey, Homer A.

“…Background: Despite the strong association of asthma exacerbations with rhinovirus (RV) infection, inoculation of asthmatic subjects with RV only causes small…”
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