Search Results - "Boursier, L."

Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity by MacDonald, CM, Boursier, L., D'Cruz, DP, Dunn-Walters, DK, Spencer, J.

“…Affinity maturation is a process by which low-affinity antibodies are transformed into highly specific antibodies in germinal centres. This process occurs by…”
Get full text

Mélanodermie et vitiligo : quand deux contraires ne font plus qu’un by Boursier, L, Weryha, G, Agopiantz, M, Klein, M, Cuny, T

“…Introduction La polyendocrinopathie auto-immune (PEAI) de type 2 associe classiquement une maladie d’Addison à plusieurs autres atteintes endocriniennes…”
Get full text

Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis by Thoree, V C, Golby, S J C, Boursier, L, Hackett, M, Dunn-Walters, D K, Sanderson, J D, Spencer, J

“…Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease in which the colonic mucosa is infiltrated with plasma cells producing IgG…”
Get full text

Anaerobic transcription activation in Bacillus subtilis: identification of distinct FNR‐dependent and ‐independent regulatory mechanisms by Cruz Ramos, H., Boursier, L., Moszer, I., Kunst, F., Danchin, A., Glaser, P.

“…Bacillus subtilis is able to grow anaerobically using alternative electron acceptors, including nitrate or fumarate. We characterized an operon encoding the…”
Get full text

Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation by Dunn-Walters, Deborah K., Boursier, Laurent, Spencer, J.O., Isaacson, Peter G.

“…Splenic marginal zone lymphoma (SMZL) is a low-grade primary splenic B cell lymphoma, originally thought to be related to splenic marginal zone B cells. Later…”
Get full text

Influence of light and feeding conditions on swimming activity rhythms of larval and juvenile turbot: Scophthalmus maximus L.: An experimental study by Champalbert, Gisèle, Le Direach-Boursier, Laurence

“…Turbot larvae are transported towards coastal nursery areas and live in very shallow waters. Food availability is assumed to be an important factor that…”
Get full text

The Bacillus subtilis genome from gerBC (311{degrees}) to licR (334{degrees}) by Presecan, E, Moszer, I, Boursier, L, Ramos, H.Cruz, de la Fuente, V, Hullo, M.-F, Lelong, C, Schleich, S, Sekowska, A, Song, B. H, Villani, G, Kunst, F, Danchin, A, Glaser, P

“…Unité de Régulation de I'Expression GénéeTique Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France Unité de Biochimie Microbienne Institut…”
Get full text

Characteristics of IgVH genes used by human intestinal plasma cells from childhood by Boursier, L, Dunn-Walters, D K, Spencer, J

“…Plasma cells secreting immunoglobulin M (IgM) and IgA in human intestinal mucosa are the largest antibody‐producing population in the human body. Despite this…”
Get full text

B-cell lymphoma associated with chronic lymphatic leukaemia: two cases with contrasting aggressive and indolent behaviour by RATNAVEL, R.C., DUNN-WALTERS, D.K., BOURSIER, L., FRAZER-ANDREWS, E., ORCHARD, G., RUSSELL-JONES, R., CALONJE, E.

“…The term Richter's syndrome is used to describe the transformation of chronic lymphatic leukaemia (CLL) into a high‐grade systemic lymphoma and is associated…”
Get full text

Cyclophosphamide et diabète de type 1 by Boursier, L., Mettavant, C., Crea, T.

“…Le cyclophosphamide est un agent alkylant immunodépresseur entraînant une inhibition de la réplication et de la transcription de l’ADN pour aboutir à une…”
Get full text

Autour d’un cas clinique : phéochromocytome sécrétant de l’ACTH by Consolandi, P., Boursier, L., Brunaud, L., Dusselier, L., Lerman, A.S., Samhani, C., Groza, L.

“…Les cas de syndrome de Cushing sur hypersécrétion d’ACTH liés à un phéochromocytome sont rares selon la littérature. Nous rapportons le cas de M. S. âgé de 65…”
Get full text

Human Intestinal IgA Response Is Generated in the Organized Gut-Associated Lymphoid Tissue but Not in the Lamina Propria by Boursier, Laurent, Gordon, John N., Thiagamoorthy, Sivashankari, Edgeworth, Jonathan D., Spencer, Jo

“…Background & Aims: The intestinal lamina propria has traditionally been viewed as the effector site of mucosal immune responses. However, this view has been…”
Get full text

Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions by Dunn-Walters, Deborah, Boursier, Laurent, Spencer, Jo

“…Immunoglobulins are known to be variably glycosylated. Although most carbohydrate is likely to be associated with the constant region, the variable region may…”
Get full text

Analysis of strand biased 'G'.C hypermutation in human immunoglobulin V sub( lambda ) gene segments suggests that both DNA strands are targets for deamination by activation-induced cytidine deaminase by Boursier, L, Su, W, Spencer, J

“…Somatic hypermutation, which diversifies the immunoglobulin repertoire by introducing mutations into rearranged IgV genes, is dependent on the expression of…”
Get full text

Spatial and temporal patterns of settlement among sparid fishes of the genus Diplodus in the northwestern Mediterranean by Vigliola, Laurent, Harmelin-Vivien, Mireille L., Biagi, Franco, Galzin, René, Garcia-Rubies, Antoni, Harmelin, Jean-Georges, Jouvenel, Jean-Yves, Le Direach-Boursier, Laurence, Macpherson, Enrique, Tunesi, Leonardo

“…Juvenile settlement of 3 sparid fish species, Diplodus puntazzo, Diplodus sargus and Diplodus vulgaris, was studied over 3 yr at 20 stations located at 5 sites…”
Get full text

Hypermutation, diversity and dissemination of human intestinal lamina propria plasma cells by Dunn-Walters, D K, Boursier, L, Spencer, J

“…In this work we have microdissected lamina propria plasma cells and used polymerase chain reaction and sequencing to investigate immunoglobulin (Ig) gene…”
Get more information

Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments by Boursier, Laurent, Su, Wen, Spencer, Jo

“…Somatic hypermutation (SHM) introduces mutations into immunoglobulin (Ig) variable gene segments, thus diversifying the B cell repertoire prior to positive…”
Get full text

Characteristics of Human IgA and IgM Genes Used by Plasma Cells in the Salivary Gland Resemble Those Used in Duodenum But Not Those Used in the Spleen by Dunn-Walters, Deborah K, Hackett, Margaret, Boursier, Laurent, Ciclitira, Paul J, Morgan, Peter, Challacombe, Stephen J, Spencer, Jo

“…Immunologically, the parotid salivary gland is an effector site that secretes large quantities of polyspecific Abs into the saliva, mainly of the IgA isotype…”
Get full text

IgV sub(H) gene analysis suggests that peritoneal B cells do not contribute to the gut immune system in man by Boursier, L, Farstad, IN, Mellembakken, J R, Brandtzaeg, P, Spencer, J

“…The contribution of peritoneal B cells to the intestinal lamina propria plasma cell population is well documented in mice, but unknown in humans. We have…”
Get full text

Biases in Ig lambda light chain rearrangements in human intestinal plasma cells by Su, Wen, Boursier, Laurent, Padala, Archana, Sanderson, Jeremy D, Spencer, Jo

“…Human intestinal lamina propria plasma cells are considered to be the progeny of chronically stimulated germinal centers located in organized gut-associated…”
Get full text