Search Results - "Bourne, Philip C."

Crystal Structure of Bacillus anthracis Dihydrofolate Reductase with the Dihydrophthalazine-Based Trimethoprim Derivative RAB1 Provides a Structural Explanation of Potency and Selectivity by BOURNE, Christina R, BUNCE, Richard A, BOURNE, Philip C, DARRELL BERLIN, K, BARROW, Esther W, BARROW, William W

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In Vitro Efficacy of New Antifolates against Trimethoprim-Resistant Bacillus anthracis by BARROW, Esther W, DREIER, Jürg, REINELT, Stefan, BOURNE, Philip C, BARROW, William W

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Synthesis and biological evaluation of 2,4-diaminopyrimidine-based antifolate drugs against Bacillus anthracis by Nammalwar, Baskar, Muddala, N Prasad, Bourne, Christina R, Henry, Mary, Bourne, Philip C, Bunce, Richard A, Barrow, Esther W, Berlin, K Darrell, Barrow, William W

“…Due to the innate ability of bacteria to develop resistance to available antibiotics, there is a critical need to develop new agents to treat more resilient…”
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Evolution of a 4‑Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders by Dou, Xiaozheng, Nath, Dinesh, Shin, Henry, Nurmemmedov, Elmar, Bourne, Philip C, Ma, Jian-Xing, Duerfeldt, Adam S

“…Peroxisome proliferator-activated receptor alpha (PPARα) is expressed in retinal Müller cells, endothelial cells, and in retinal pigment epithelium; agonism…”
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Functional Cloning of Bacillus anthracis Dihydrofolate Reductase and Confirmation of Natural Resistance to Trimethoprim by BARROW, Esther W, BOURNE, Philip C, BARROW, William W

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Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis by Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.

“…A series of substituted 2,4-diaminopyrimidines 1 has been prepared and evaluated for activity against Bacillus anthracis using previously reported…”
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Newly developed colorimetric drug screening assay for Bacillus anthracis by Barrow, Esther W., Valderas, Michelle Wright, Bourne, Philip C., Barrow, William W.

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Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis by Nammalwar, Baskar, Bourne, Christina R., Wakeham, Nancy, Bourne, Philip C., Barrow, Esther W., Muddala, N. Prasad, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.

“…[Display omitted] The current Letter describes the synthesis and biological evaluation of dihydrophthalazine-appended 2,4-diaminopyrimidine (DAP) inhibitors…”
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The atomic-resolution structure of a novel bacterial esterase by Bourne, Philip C, Isupov, Michail N, Littlechild, Jennifer A

“…Background: A novel bacterial esterase that cleaves esters on halogenated cyclic compounds has been isolated from an Alcaligenes species. This esterase 713 is…”
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Structure–activity relationship for enantiomers of potent inhibitors of B. anthracis dihydrofolate reductase by Bourne, Christina R., Wakeham, Nancy, Nammalwar, Baskar, Tseitin, Vladimir, Bourne, Philip C., Barrow, Esther W., Mylvaganam, Shankari, Ramnarayan, Kal, Bunce, Richard A., Berlin, K. Darrell, Barrow, William W.

“…Background: Bacterial resistance to antibiotic therapies is increasing and new treatment options are badly needed. There is an overlap between these resistant…”
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Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines by Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.

“…(±)‐6‐Alkyl‐2,4‐diaminopyrimidine‐based inhibitors of bacterial dihydrofolate reductase (DHFR) have been prepared and evaluated for biological potency against…”
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Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4-Diaminopyrimidine-based Antibiotics by Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.

“…Organic Preparations and Procedures International Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of…”
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High-throughput screening of a diversity collection using biodefense category A and B priority pathogens by Barrow, Esther W, Clinkenbeard, Patricia A, Duncan-Decocq, Rebecca A, Perteet, Rachel F, Hill, Kimberly D, Bourne, Philip C, Valderas, Michelle W, Bourne, Christina R, Clarkson, Nicole L, Clinkenbeard, Kenneth D, Barrow, William W

“…One of the objectives of the National Institutes of Allergy and Infectious Diseases (NIAID) Biodefense Program is to identify or develop broad-spectrum…”
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Inside Cover: Inhibition of Bacterial Dihydrofolate Reductase by 6-Alkyl-2,4-diaminopyrimidines (ChemMedChem 11/2012) by Nammalwar, Baskar, Bourne, Christina R., Bunce, Richard A., Wakeham, Nancy, Bourne, Philip C., Ramnarayan, Kal, Mylvaganam, Shankari, Berlin, K. Darrell, Barrow, Esther W., Barrow, William W.

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Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics by Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.

“…Organic Preparations and Procedures International Microwave-assisted Heck Synthesis of Substituted 2,4-Diaminopyrimidine-based Antibiotics…”
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Approaches to Iodinated Derivatives of Vanillin and Isovanillin by Nammalwar, Baskar, Bunce, Richard A., Berlin, K. Darrell, Bourne, Christina R., Bourne, Philip C., Barrow, Esther W., Barrow, William W.

“…Organic Preparations and Procedures International Approaches to Iodinated Derivatives of Vanillin and Isovanillin…”
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Genetic basis for sulfonamide resistance in Bacillus anthracis by Valderas, Michelle Wright, Bourne, Philip C, Barrow, William W

“…Natural resistance of field strains of Bacillus anthracis to drugs from the sulfonamide class of antimicrobials that act by inhibiting dihydropteroate synthase…”
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Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties by Bourne, Philip C., Ramsland, Paul A., Shan, Lin, Fan, Zhao-C., DeWitt, Christina R., Shultz, Brandon B., Terzyan, Simon S., Moomaw, Carolyn R., Slaughter, Clive A., Guddat, Luke W., Edmundson, Allen B.

“…The X‐ray structure of an immunoglobulin light‐chain dimer isolated from the urine as a `Bence‐Jones protein' from a patient with multiple myeloma and…”
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Three-dimensional structures of a humanized anti-IFN-γ Fab (HuZAF) in two crystal forms by Bourne, Philip C., Terzyan, Simon S., Cloud, Gwendolyn, Landolfi, Nicholas F., Vásquez, Maximiliano, Edmundson, Allen B.

“…Three‐dimensional structures were determined for two crystal forms (orthorhombic P212121 and monoclinic C2) of the Fab from the humanized version of a murine…”
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Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95 by Terzyan, Simon S., Bourne, Christina R., Ramsland, Paul A., Bourne, Philip C., Edmundson, Allen B.

“…Crystals of a human (Sea) Bence‐Jones dimer were produced in a capillary by vapor diffusion under microgravity conditions in the 9 day US Space Shuttle Mission…”
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