Search Results - "Bourguignon, Aurore"
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The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent
Published in Frontiers in immunology (09-10-2018)“…In spite of impressive response rates in multiple cancer types, immune checkpoint inhibitors (ICIs) are active in only a minority of patients. Alternative…”
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Increased mitochondrial energy efficiency in skeletal muscle after long-term fasting: its relevance to animal performance
Published in Journal of experimental biology (01-07-2017)“…In the final stage of fasting, skeletal muscle mass and protein content drastically decrease when the maintenance of efficient locomotor activity becomes…”
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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat
Published in Toxicology in vitro (01-06-2022)“…Most OECD guidelines for chemical risk assessment include tests performed on animals, raising financial, ethical and scientific concerns. Thus, the development…”
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Skeletal muscle metabolism in sea-acclimatized king penguins. II. Improved efficiency of mitochondrial bioenergetics
Published in Journal of experimental biology (04-11-2020)“…At fledging, juvenile king penguins ( ) must overcome the tremendous energetic constraints imposed by their marine habitat, including during sustained…”
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Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures
Published in Toxicology in vitro (01-06-2024)“…Human induced pluripotent stem cells (iPSC) have the potential to produce desired target cell types in vitro and allow for the high-throughput screening of…”
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Abstract 2723: In vivo activity of combinations of cytotoxic regimens with anti-PD1 and anti-PDL1 in various syngeneic cancer models
Published in Cancer research (Chicago, Ill.) (01-07-2018)“…Immune checkpoint inhibitors (ICIs) show impressive response rate in multiple cancer types. Nivolumab and atezolizumab has already been approved by the FDA…”
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Mitochondrial oxidative phosphorylation efficiency is upregulated during fasting in two major oxidative tissues of ducklings
Published in Comparative biochemistry and physiology. Part A, Molecular & integrative physiology (01-10-2017)“…Fasted endothermic vertebrates must develop physiological responses to maximize energy conservation and survival. The aim of this study was to determine the…”
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Skeletal muscle metabolism in sea-acclimatized king penguins: II. Improved efficiency of mitochondrial bioenergetics
Published in Journal of experimental biology (01-01-2020)“…At fledging, juvenile king penguins (Aptenodytes patagonicus) must overcome the tremendous energetic constraints imposed by their marine habitat, including…”
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Lipid-induced thermogenesis is up-regulated by the first cold-water immersions in juvenile penguins
Published in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology (01-07-2016)“…The passage from shore to marine life is a critical step in the development of juvenile penguins and is characterized by a fuel selection towards lipid…”
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