Search Results - "Bourgier, Emmanuelle"

Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs by Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, André, Green, Jonathan R., Jahnke, Wolfgang

“…To understand the structural basis for bisphosphonate therapy of bone diseases, we solved the crystal structures of human farnesyl pyrophosphate synthase…”
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SEC-TID: A Label-Free Method for Small-Molecule Target Identification by Salcius, Michael, Bauer, Andras J, Hao, Qin, Li, Shu, Tutter, Antonin, Raphael, Jacob, Jahnke, Wolfgang, Rondeau, Jean-Michel, Bourgier, Emmanuelle, Tallarico, John, Michaud, Gregory A

“…Bioactive small molecules are an invaluable source of therapeutics and chemical probes for exploring biological pathways. Yet, significant hurdles in drug…”
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A General Strategy for Targeting Drugs to Bone by Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel

“…Targeting drugs to their desired site of action can increase their safety and efficacy. Bisphosphonates are prototypical examples of drugs targeted to bone…”
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Discovery of Novel Allosteric Non-Bisphosphonate Inhibitors of Farnesyl Pyrophosphate Synthase by Integrated Lead Finding by Marzinzik, Andreas L., Amstutz, René, Bold, Guido, Bourgier, Emmanuelle, Cotesta, Simona, Glickman, J. Fraser, Götte, Marjo, Henry, Christelle, Lehmann, Sylvie, Hartwieg, J. Constanze D., Ofner, Silvio, Pellé, Xavier, Roddy, Thomas P., Rondeau, Jean-Michel, Stauffer, Frédéric, Stout, Steven J., Widmer, Armin, Zimmermann, Johann, Zoller, Thomas, Jahnke, Wolfgang

“…Farnesyl pyrophosphate synthase (FPPS) is an established target for the treatment of bone diseases, but also shows promise as an anticancer and anti‐infective…”
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Gezielte Anreicherung von Wirkstoffen am Knochen am Beispiel von allosterischen FPPS‐Inhibitoren by Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean‐Michel

“…Die Wirksamkeit und Verträglichkeit eines Medikaments kann verbessert werden, indem dieses gezielt an den gewünschten Wirkungsort gebracht wird. Bisphosphonate…”
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Gezielte Anreicherung von Wirkstoffen am Knochen am Beispiel von allosterischen FPPS-Inhibitoren by Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel

“…Abstract Die Wirksamkeit und Verträglichkeit eines Medikaments kann verbessert werden, indem dieses gezielt an den gewünschten Wirkungsort gebracht wird…”
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Cover Picture: Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs (ChemMedChem 2/2006) by Rondeau, Jean-Michel, Bitsch, Francis, Bourgier, Emmanuelle, Geiser, Martin, Hemmig, Rene, Kroemer, Markus, Lehmann, Sylvie, Ramage, Paul, Rieffel, Sebastien, Strauss, André, Green, Jonathan R., Jahnke, Wolfgang

“…The cover picture shows micro computer tomography images that demonstrate the effect of zoledronate in the prevention of the tumor osteolytic response caused…”
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