Search Results - "Bourghardt, Johan"

Protein phase separation and its role in tumorigenesis by Jiang, Shan, Fagman, Johan Bourghardt, Chen, Changyan, Alberti, Simon, Liu, Beidong

“…Cancer is a disease characterized by uncontrolled cell proliferation, but the precise pathological mechanisms underlying tumorigenesis often remain to be…”
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High expression of p62/SQSTM1 predicts shorter survival for patients with pancreatic cancer by Philipson, Eva, Engström, Cecilia, Naredi, Peter, Bourghardt Fagman, Johan

“…Accumulation of the signal adaptor protein p62 has been demonstrated in many forms of cancer, including pancreatic ductal adenocarcinoma (PDAC). Although data…”
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Androgen Receptor-Dependent and Independent Atheroprotection by Testosterone in Male Mice by Bourghardt, Johan, Wilhelmson, Anna S. K, Alexanderson, Camilla, De Gendt, Karel, Verhoeven, Guido, Krettek, Alexandra, Ohlsson, Claes, Tivesten, Åsa

“…The atheroprotective effect of testosterone is thought to require aromatization of testosterone to estradiol, but no study has adequately addressed the role of…”
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Deficiency of mature B cells does not alter the atherogenic response to castration in male mice by Wilhelmson, Anna S., Johansson, Inger, Fogelstrand, Linda, Fagman, Johan Bourghardt, Arnal, Jean-Francois, Karlsson, Mikael C. I., Tivesten, Åsa

“…Testosterone deficiency in men is associated with increased atherosclerosis burden and increased cardiovascular risk. In male mice, testosterone deficiency…”
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Androgen Receptors in Epithelial Cells Regulate Thymopoiesis and Recent Thymic Emigrants in Male Mice by Wilhelmson, Anna S, Lantero Rodriguez, Marta, Johansson, Inger, Svedlund Eriksson, Elin, Stubelius, Alexandra, Lindgren, Susanne, Fagman, Johan Bourghardt, Fink, Pamela J, Carlsten, Hans, Ekwall, Olov, Tivesten, Åsa

“…Androgens have profound effects on T cell homeostasis, including regulation of thymic T lymphopoiesis (thymopoiesis) and production of recent thymic emigrants…”
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Fractional uptake of circulating tumor cells into liver-lung compartments during curative resection of periampullary cancer by Vilhav, Caroline, Engström, Cecilia, Naredi, Peter, Novotny, Ann, Bourghardt-Fagman, Johan, Iresjö, Britt-Marie, Asting, Annika G, Lundholm, Kent

“…Circulating tumor cells (CTCs) are able to predict outcome in patients with breast, colon and prostate cancer and appear to be promising biomarkers of…”
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Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti‑tumor immunity in the tumor stroma by Khan, Maria, Engström, Cecilia, Fagman, Johan Bourghardt, Smedh, Ulrika, Lundholm, Kent, Iresjö, Britt-Marie

“…Inflammatory signaling through prostaglandin E2 receptor subtype 2 (EP2) is associated with malignant tumor growth in both experimental models and cancer…”
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Genetics and Therapeutic Responses to Tumor-Infiltrating Lymphocyte Therapy of Pancreatic Cancer Patient-Derived Xenograft Models by Nilsson, Lisa M., Vilhav, Caroline, Karlsson, Joakim W., Fagman, Johan Bourghardt, Giglio, Daniel, Engström, Cecilia E., Naredi, Peter, Nilsson, Jonas A.

“…Pancreatic cancer is the seventh leading cause of cancer-related deaths worldwide. Checkpoint immunotherapy has not yet shown encouraging results in pancreatic…”
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The Endogenous Estradiol Metabolite 2-Methoxyestradiol Reduces Atherosclerotic Lesion Formation in Female Apolipoprotein E-Deficient Mice by Bourghardt, Johan, Bergström, Göran, Krettek, Alexandra, Sjöberg, Sara, Borén, Jan, Tivesten, Åsa

“…Estradiol, the major endogenous estrogen, reduces experimental atherosclerosis and metabolizes to 2-methoxyestradiol in vascular cells. Currently undergoing…”
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Exosomal secretion of death bullets: a new way of apoptotic escape? by Trokovic, Nina, Pöllänen, Raimo, Porola, Pauliina, Stegaev, Vasily, Hetzel, Udo, Tivesten, Åsa, Engdahl, Cecilia, Carlsten, Hans, Forsblad-d'Elia, Helena, Fagman, Johan Bourghardt, Lagerquist, Marie, Konttinen, Yrjö T

“…Ovariectomy/estrogen deficiency causes selective apoptosis of the serous epithelial cells of the submandibular glands (SMG) in female mice. Because such…”
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Impact of Surgery-Induced Myeloid-derived Suppressor Cells and the NOX2/ROS Axis on Postoperative Survival in Human Pancreatic Cancer by Grauers Wiktorin, Hanna, Aydin, Ebru, Kiffin, Roberta, Vilhav, Caroline, Bourghardt Fagman, Johan, Kaya, Mustafa, Paul, Sanchari, Westman, Beatrice, Bratlie, Svein Olav, Naredi, Peter, Hellstrand, Kristoffer, Martner, Anna

“…Preclinical studies imply that surgery triggers inflammation that may entail tumor outgrowth and metastasis. The potential impact of surgery-induced…”
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Catechol-O-Methyltransferase Is Dispensable for Vascular Protection by Estradiol in Mouse Models of Atherosclerosis and Neointima Formation by Wilhelmson, Anna S, Bourghardt-Fagman, Johan, Gogos, Joseph A, Fogelstrand, Per, Tivesten, Åsa

“…Estradiol is converted to the biologically active metabolite 2-methoxyestradiol via the activity of the enzyme catechol-O-methyltransferase (COMT). Exogenous…”
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Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress by Antonucci, Laura, Fagman, Johan B., Kim, Ju Youn, Todoric, Jelena, Gukovsky, Ilya, Mackey, Mason, Ellisman, Mark H., Karin, Michael

“…Pancreatic acinar cells possess very high protein synthetic rates as they need to produce and secrete large amounts of digestive enzymes. Acinar cell damage…”
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A comprehensive review of pancreatic cancer and its therapeutic challenges by Jiang, Shan, Fagman, Johan Bourghardt, Ma, Yunyun, Liu, Jian, Vihav, Caroline, Engstrom, Cecilia, Liu, Beidong, Chen, Changyan

“…Pancreatic cancer is a devastating and lethal human malignancy with no curable chemo-treatments available thus far. More than 90% of pancreatic tumors are…”
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Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increase local anti-tumor immunity in the tumor stroma by Khan, Maria, Engström, Cecilia, Fagman, Johan Bourghardt, Smedh, Ulrika, Lundholm, Kent, Iresjö, Britt-Marie

“…Inflammatory signaling through prostaglandin E2 receptor subtype 2 (EP2) is associated with malignant tumor growth in both experimental models and cancer…”
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Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas by Todoric, Jelena, Antonucci, Laura, Di Caro, Giuseppe, Li, Ning, Wu, Xuefeng, Lytle, Nikki K., Dhar, Debanjan, Banerjee, Sourav, Fagman, Johan B., Browne, Cecille D., Umemura, Atsushi, Valasek, Mark A., Kessler, Hannes, Tarin, David, Goggins, Michael, Reya, Tannishtha, Diaz-Meco, Maria, Moscat, Jorge, Karin, Michael

“…Despite expression of oncogenic KRAS, premalignant pancreatic intraepithelial neoplasia 1 (PanIN1) lesions rarely become fully malignant pancreatic ductal…”
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Low doses of arsenic, via perturbing p53, promotes tumorigenesis by Ganapathy, Suthakar, Li, Ping, Fagman, Johan, Yu, Tianqi, Lafontant, Jean, Zhang, Guojun, Chen, Changyan

“…In drinking water and in workplace or living environments, low doses of arsenic can exist and operate as a potent carcinogen. Due to insufficient understanding…”
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C-reactive Protein Identifies Patients at Risk of Postpancreatectomy Hemorrhage by Vilhav, C., Bourghardt Fagman, J., Holmberg, E., Naredi, P., Engström, C.

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C-reactive protein identifies patients at risk of postpancreatectomy hemorrhage by Vilhav, C., Fagman, J. B., Holmberg, E., Naredi, P., Engström, C.

“…Background Postpancreatectomy hemorrhage grade C (PPH C) is a dreaded complication after pancreaticoduodenectomy (PD) with high mortality rate. Concurrent risk…”
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Genetics and Therapeutic Responses to Tumor-infiltrating Lymphocyte Therapy of Pancreatic Cancer Patient-derived Xenograft Models by Vilhav, C., Nilsson, L.M., Karlsson, J.W., Fagman, J.B., Giglio, D., Engström, C.E., Naredi, P., Nilsson, J.A.

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