Search Results - "Bourgeois, Jeffrey S"

The Bioavailability of Soluble Cigarette Smoke Extract Is Reduced through Interactions with Cells and Affects the Cellular Response to CSE Exposure by Bourgeois, Jeffrey S, Jacob, Jeeva, Garewal, Aram, Ndahayo, Renata, Paxson, Julia

“…Cellular exposure to cigarette smoke leads to an array of complex responses including apoptosis, cellular senescence, telomere dysfunction, cellular aging, and…”
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ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice by Bourgeois, Jeffrey S., Wang, Liuyang, Rabino, Agustin F., Everitt, Jeffrey, Alvarez, Monica I., Awadia, Sahezeel, Wittchen, Erika S., Garcia-Mata, Rafael, Ko, Dennis C.

“…Salmonella hijack host machinery in order to invade cells and establish infection. While considerable work has described the role of host proteins in invasion,…”
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Integration of the Salmonella Typhimurium Methylome and Transcriptome Reveals That DNA Methylation and Transcriptional Regulation Are Largely Decoupled under Virulence-Related Conditions by Bourgeois, Jeffrey S, Anderson, Caroline E, Wang, Liuyang, Modliszewski, Jennifer L, Chen, Wei, Schott, Benjamin H, Devos, Nicolas, Ko, Dennis C

“…Despite being in a golden age of bacterial epigenomics, little work has systematically examined the plasticity and functional impacts of the bacterial DNA…”
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Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia by Sheikh, Virginia, Porter, Brian O., DerSimonian, Rebecca, Kovacs, Stephen B., Thompson, William L., Perez-Diez, Ainhoa, Freeman, Alexandra F., Roby, Gregg, Mican, JoAnn, Pau, Alice, Rupert, Adam, Adelsberger, Joseph, Higgins, Jeanette, Bourgeois, Jeffrey S., Jensen, Stig M.R., Morcock, David R., Burbelo, Peter D., Osnos, Leah, Maric, Irina, Natarajan, Ven, Croughs, Therese, Yao, Michael D., Estes, Jacob D., Sereti, Irini

“…Idiopathic CD4 lymphopenia (ICL) is a rare syndrome defined by low CD4 T-cell counts (<300/µL) without evidence of HIV infection or other known cause of…”
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Hitchhiker's Guide to Borrelia burgdorferi by Bourgeois, Jeffrey S, Hu, Linden T

“…Don't Panic. In the nearly 50 years since the discovery of Lyme disease, has emerged as an unlikely workhorse of microbiology. Interest in studying…”
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A putative xanthine dehydrogenase is critical for Borrelia burgdorferi survival in ticks and mice by Phelan, James P, Bourgeois, Jeffrey S, McCarthy, Julie E, Hu, Linden T

“…is a pathogenic bacterium and the causative agent of Lyme disease. It is exposed to reactive oxygen species (ROS) in both the vertebrate and tick hosts. While…”
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These Are the Genes You’re Looking For: Finding Host Resistance Genes by Bourgeois, Jeffrey S., Smith, Clare M., Ko, Dennis C.

“…Humanity’s ongoing struggle with new, re-emerging and endemic infectious diseases serves as a frequent reminder of the need to understand host–pathogen…”
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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3 by Gibbs, Kyle D., Washington, Erica J., Jaslow, Sarah L., Bourgeois, Jeffrey S., Foster, Matthew W., Guo, Robyn, Brennan, Richard G., Ko, Dennis C.

“…Bacteria masterfully co-opt and subvert host signal transduction. As a paradigmatic example, Salmonella uses two type-3 secretion systems to inject effector…”
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Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia by Perez-Diez, Ainhoa, Wong, Chun-Shu, Liu, Xiangdong, Mystakelis, Harry, Song, Jian, Lu, Yong, Sheikh, Virginia, Bourgeois, Jeffrey S, Lisco, Andrea, Laidlaw, Elizabeth, Cudrici, Cornelia, Zhu, Chengsong, Li, Quan-Zhen, Freeman, Alexandra F, Williamson, Peter R, Anderson, Megan, Roby, Gregg, Tsang, John S, Siegel, Richard, Sereti, Irini

“…BACKGROUNDIdiopathic CD4 lymphopenia (ICL) is defined by persistently low CD4+ cell counts (<300 cells/μL) in the absence of a causal infection or immune…”
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Methylthioadenosine Suppresses Salmonella Virulence by Bourgeois, Jeffrey S, Zhou, Daoguo, Thurston, Teresa L M, Gilchrist, James J, Ko, Dennis C

“…In order to deploy virulence factors at appropriate times and locations, microbes must rapidly sense and respond to various metabolite signals. Previously, we…”
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Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivation by Gibbs, Kyle D., Wang, Liuyang, Yang, Zhuo, Anderson, Caroline E., Bourgeois, Jeffrey S., Cao, Yanlu, Gaggioli, Margaret R., Biel, Martin, Puertollano, Rosa, Chen, Cheng-Chang, Ko, Dennis C.

“…Human genetic diversity can reveal critical factors in host-pathogen interactions. This is especially useful for human-restricted pathogens like Salmonella…”
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Single-cell genome-wide association reveals that a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus by Schott, Benjamin H., Wang, Liuyang, Zhu, Xinyu, Harding, Alfred T., Ko, Emily R., Bourgeois, Jeffrey S., Washington, Erica J., Burke, Thomas W., Anderson, Jack, Bergstrom, Emma, Gardener, Zoe, Paterson, Suzanna, Brennan, Richard G., Chiu, Christopher, McClain, Micah T., Woods, Christopher W., Gregory, Simon G., Heaton, Nicholas S., Ko, Dennis C.

“…During pandemics, individuals exhibit differences in risk and clinical outcomes. Here, we developed single-cell high-throughput human in vitro susceptibility…”
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Prevalence and pathogenicity of autoantibodies in patients with idiopathic CD4 lymphopenia by Perez-Diez, Ainhoa, Wong, Chun-Shu, Liu, Xiangdong, Mystakelis, Harry, Song, Jian, Lu, Yong, Sheikh, Virginia, Bourgeois, Jeffrey S, Lisco, Andrea, Laidlaw, Elizabeth, Cudrici, Cornelia, Zhu, Chengsong, Li, Quan-Zhen, Freeman, Alexandra F, Williamson, Peter R, Anderson, Megan, Roby, Gregg, Tsang, John S, Siegel, Richard, Sereti, Irini

“…BACKGROUND. Idiopathic CD4 lymphopenia (ICL) is defined by persistently low CD4+ cell counts (<300 cells/µL) in the absence of a causal infection or immune…”
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ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice by Bourgeois, Jeffrey S, Wang, Liuyang, Rabino, Agustin F, Everitt, Jeffrey, Alvarez, Monica I, Awadia, Sahezeel, Wittchen, Erika S, Garcia-Mata, Rafael, Ko, Dennis C

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