Search Results - "Bourgeat, Pierrick"
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Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study
Published in Lancet neurology (01-04-2013)“…Summary Background Similar to most chronic diseases, Alzheimer's disease (AD) develops slowly from a preclinical phase into a fully expressed clinical…”
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Predicting motor outcome in preterm infants from very early brain diffusion MRI using a deep learning convolutional neural network (CNN) model
Published in NeuroImage (Orlando, Fla.) (15-07-2020)“…Preterm birth imposes a high risk for developing neuromotor delay. Earlier prediction of adverse outcome in preterm infants is crucial for referral to earlier…”
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Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer's disease pathophysiology (SNAP) or Alzheimer's disease pathology: a longitudinal study
Published in Lancet neurology (01-09-2016)“…Summary Background Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50–60% of cognitively healthy elderly individuals (aged…”
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Lesion segmentation from multimodal MRI using random forest following ischemic stroke
Published in NeuroImage (Orlando, Fla.) (01-09-2014)“…Understanding structure–function relationships in the brain after stroke is reliant not only on the accurate anatomical delineation of the focal ischemic…”
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Using imputation to provide harmonized longitudinal measures of cognition across AIBL and ADNI
Published in Scientific reports (10-12-2021)“…To improve understanding of Alzheimer’s disease, large observational studies are needed to increase power for more nuanced analyses. Combining data across…”
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Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging
Published in Neurobiology of aging (01-08-2010)“…Abstract The Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging, a participant of the worldwide Alzheimer's Disease Neuroimaging Initiative…”
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Relationship between amyloid and tau levels and its impact on tau spreading
Published in European journal of nuclear medicine and molecular imaging (01-07-2021)“…Purpose Previous studies have shown that Aβ-amyloid (Aβ) likely promotes tau to spread beyond the medial temporal lobe. However, the Aβ levels necessary for…”
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Disease progression modelling of Alzheimer’s disease using probabilistic principal components analysis
Published in NeuroImage (Orlando, Fla.) (01-09-2023)“…•The first component of probabilistic principal component analysis can summarise patient states in a single score by capturing variability in Alzheimer’s…”
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Aβ-amyloid and Tau Imaging in Dementia
Published in Seminars in nuclear medicine (01-01-2017)“…The introduction of in vivo imaging of Aβ-amyloid (Αβ) pathology more than a decade ago, transformed the assessment of Alzheimer disease (AD) allowing the…”
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Non-negative matrix factorisation improves Centiloid robustness in longitudinal studies
Published in NeuroImage (Orlando, Fla.) (01-02-2021)“…: Centiloid was introduced to harmonise β-Amyloid (Aβ) PET quantification across different tracers, scanners and analysis techniques. Unfortunately, Centiloid…”
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Comparison of MR-less PiB SUVR quantification methods
Published in Neurobiology of aging (2015)“…Abstract11 C-Pittsburgh compound B (PiB) is a positron emission tomography (PET) tracer designed to bind to amyloid-β (Aβ) plaques, one of the hallmarks of…”
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Statistical machine learning to identify traumatic brain injury (TBI) from structural disconnections of white matter networks
Published in NeuroImage (Orlando, Fla.) (01-04-2016)“…Identifying diffuse axonal injury (DAI) in patients with traumatic brain injury (TBI) presenting with normal appearing radiological MRI presents a significant…”
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β-amyloid PET harmonisation across longitudinal studies: Application to AIBL, ADNI and OASIS3
Published in NeuroImage (Orlando, Fla.) (15-11-2022)“…•Largest multi-centre harmonisation study of Amyloid PET images.•Systematic evaluation of different harmonisation strategies.•Using NMF improves inter-tracer…”
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Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models
Published in NeuroImage (Orlando, Fla.) (01-02-2012)“…The hippocampus is affected at an early stage in the development of Alzheimer's disease (AD). With the use of structural magnetic resonance (MR) imaging, we…”
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Comparison of 18F-florbetaben quantification results using the standard Centiloid, MR-based, and MR-less CapAIBL® approaches: Validation against histopathology
Published in Alzheimer's & dementia (01-06-2019)“…18F-florbetaben is currently approved for the visual rule out of β-amyloid (Aβ) pathology. It is also used for recruitment and as an outcome measure in…”
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Evaluation of novel data-driven metrics of amyloid β deposition for longitudinal PET studies
Published in NeuroImage (Orlando, Fla.) (15-10-2023)“…•Novel data-driven approaches to quantifying amyloid burden from in-vivo PET imaging have been developed to address common sources of variability such as the…”
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The interplay of age, gender and amyloid on brain and cognition in mid-life and older adults
Published in Scientific reports (08-11-2024)“…Deficits in memory are seen as a canonical sign of aging and a prodrome to dementia in older adults. However, our understanding of age-related cognition and…”
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Visually Identified Tau 18F-MK6240 PET Patterns in Symptomatic Alzheimer's Disease
Published in Journal of Alzheimer's disease (16-08-2022)“…In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in…”
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Reduced cortical cholinergic innervation measured using [18F]-FEOBV PET imaging correlates with cognitive decline in mild cognitive impairment
Published in NeuroImage clinical (01-01-2022)“…•Topographic FEOBV binding correlates with domain-specific cognitive performance.•Global and regional reductions in cholinergic innervation are observed in…”
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Cerebrospinal fluid neurofilament light concentration predicts brain atrophy and cognition in Alzheimer's disease
Published in Alzheimer's & dementia : diagnosis, assessment & disease monitoring (2020)“…Introduction This study assessed the utility of cerebrospinal fluid (CSF) neurofilament light (NfL) in Alzheimer's disease (AD) diagnosis, its association with…”
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