Search Results - "Bourdon, Jean"
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lidR: An R package for analysis of Airborne Laser Scanning (ALS) data
Published in Remote sensing of environment (15-12-2020)“…Airborne laser scanning (ALS) is a remote sensing technology known for its applicability in natural resources management. By quantifying the three-dimensional…”
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The Emerging Landscape of p53 Isoforms in Physiology, Cancer and Degenerative Diseases
Published in International journal of molecular sciences (11-12-2019)“…p53, first described four decades ago, is now established as a master regulator of cellular stress response, the "guardian of the genome". p53 contributes to…”
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p53 Isoforms: Key Regulators of the Cell Fate Decision
Published in Cold Spring Harbor perspectives in medicine (01-08-2016)“…It is poorly understood how a single protein, p53, can be responsive to so many stress signals and orchestrates very diverse cell responses to maintain/restore…”
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Adaptive homeostasis and the p53 isoform network
Published in EMBO reports (06-12-2021)“…All living organisms have developed processes to sense and address environmental changes to maintain a stable internal state (homeostasis). When activated, the…”
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From neurodiversity to neurodivergence: the role of epistemic and cognitive marginalization
Published in Synthese (Dordrecht) (01-12-2021)“…Diversity is an undeniable fact of nature (Gaston and Spicer in Biodiversity: an introduction. Wiley, Hoboken, 2004), and there is now evidence that nature did…”
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Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
Published in OncoTargets and therapy (19-12-2013)“…Thirty-five years of research on p53 gave rise to more than 68,000 articles and reviews, but did not allow the uncovering of all the mysteries that this major…”
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Assessing spatial patterns of burn severity for guiding post-fire salvage logging in boreal forests of Eastern Canada
Published in Forest ecology and management (15-03-2024)“…Areas affected by forest fires are increasing worldwide, making salvage logging (i.e., harvesting fire-affected trees) an increasingly used practice to reduce…”
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Correction, update, and enhancement of vectorial forestry road maps using ALS data, a pathfinder, and seven metrics
Published in International journal of applied earth observation and geoinformation (01-11-2022)“…Accurate information about forestry roads is a key aspect of forest management in terms of economy (e.g. accessibility, cost, optimal path) and ecology (e.g…”
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p53 isoforms differentially impact on the POLι dependent DNA damage tolerance pathway
Published in Cell death & disease (13-10-2021)“…The recently discovered p53-dependent DNA damage tolerance (DDT) pathway relies on its biochemical activities in DNA-binding, oligomerization, as well as…”
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Δ133p53β isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells
Published in Nature communications (15-09-2021)“…The p53 isoform, Δ133p53β, is critical in promoting cancer. Here we report that Δ133p53β activity is regulated through an aggregation-dependent mechanism…”
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Vectorial and topologically valid segmentation of forestry road networks from ALS data
Published in International journal of applied earth observation and geoinformation (01-04-2023)“…Accurate information on road location is critical for forest management and conservation strategies. Road location data supports the analysis of road…”
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Giving Ecological Meaning to Satellite-Derived Fire Severity Metrics across North American Forests
Published in Remote sensing (Basel, Switzerland) (23-07-2019)“…Satellite-derived spectral indices such as the relativized burn ratio (RBR) allow fire severity maps to be produced in a relatively straightforward manner…”
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Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA
Published in Oncogene (10-03-2021)“…Recent years have seen an increasing number of genetically engineered pig models of human diseases including cancer. We previously generated pigs with a…”
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Expression of p53 protein isoforms predicts survival in patients with multiple myeloma
Published in American journal of hematology (01-06-2022)“…Loss and/or mutation of the TP53 gene are associated with short survival in multiple myeloma, but the p53 landscape goes far beyond. At least 12 p53 protein…”
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p53 Acts as a Safeguard of Translational Control by Regulating Fibrillarin and rRNA Methylation in Cancer
Published in Cancer cell (09-09-2013)“…Ribosomes are specialized entities that participate in regulation of gene expression through their rRNAs carrying ribozyme activity. Ribosome biogenesis is…”
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Effect of p53 and its N‐terminally truncated isoform, Δ40p53, on breast cancer migration and invasion
Published in Molecular oncology (01-01-2022)“…Breast cancer is the most diagnosed malignancy in women, with over half a million women dying from this disease each year. In our previous studies, ∆40p53, an…”
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Δ133p53 coordinates ECM-driven morphogenesis and gene expression in three-dimensional mammary epithelial acini
Published in Journal of cell science (01-11-2022)“…Growing evidence indicates that p53 (encoded by TP53) has a crucial role in normal tissue development. The role of the canonical p53 (p53α) and its 12 isoforms…”
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The pleiotropic role of p53 in functional/dysfunctional neurons: focus on pathogenesis and diagnosis of Alzheimer's disease
Published in Alzheimer's research & therapy (03-12-2020)“…Understanding the earliest pathophysiological changes of Alzheimer's disease (AD) may aid in the search for timely diagnostic biomarkers and effective…”
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Delay in development and behavioural abnormalities in the absence of p53 in zebrafish
Published in PloS one (19-07-2019)“…p53 is well-known for its tumour-suppressive activity. However, in the past decade it became clear that p53 is also involved in other processes including stem…”
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The Nonstructural NS1 Protein of Influenza Viruses Modulates TP53 Splicing through Host Factor CPSF4
Published in Journal of virology (01-04-2019)“…Influenza A viruses (IAV) are known to modulate and "hijack" several cellular host mechanisms, including gene splicing and RNA maturation machineries. These…”
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