Search Results - "Bourdon, J"

p53 and its isoforms in cancer by BOURDON, J.-C

“…p53, p63 and p73 are members of the p53 gene family involved in development, differentiation and response to cellular stress. p53 gene is a transcription…”
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Biological functions of p53 isoforms through evolution: lessons from animal and cellular models by Marcel, V, Dichtel-Danjoy, M-L, Sagne, C, Hafsi, H, Ma, D, Ortiz-Cuaran, S, Olivier, M, Hall, J, Mollereau, B, Hainaut, P, Bourdon, J-C

“…The TP53 tumour-suppressor gene is expressed as several protein isoforms generated by different mechanisms, including use of alternative promoters, splicing…”
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p53 p63 p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress by Murray-Zmijewski, F, Lane, D P, Bourdon, J-C

“…p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development. p53 is the most frequently mutated gene in…”
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Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response by Marcel, V, Fernandes, K, Terrier, O, Lane, D P, Bourdon, J-C

“…In addition to the tumor suppressor p53 protein, also termed p53 α , the TP53 gene produces p53 β and p53 γ through alternative splicing of exons 9 β and 9 γ…”
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p53 is activated in response to disruption of the pre-mRNA splicing machinery by Allende-Vega, N, Dayal, S, Agarwala, U, Sparks, A, Bourdon, J-C, Saville, M K

“…In this study, we show that interfering with the splicing machinery results in activation of the tumour-suppressor p53. The spliceosome was targeted by small…”
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Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors by Dalvai, M, Mondesert, O, Bourdon, J-C, Ducommun, B, Dozier, C

“…Cdc25B phosphatases function as key players in G2/M cell cycle progression by activating the CDK1–cyclinB1 complexes. They also have an essential role in…”
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The isoforms of the p53 protein by Khoury, Marie P, Bourdon, Jean-Christophe

“…p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of…”
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Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia by Ånensen, N, Hjelle, S M, Van Belle, W, Haaland, I, Silden, E, Bourdon, J-C, Hovland, R, Taskén, K, Knappskog, S, Lønning, P E, Bruserud, Ø, Gjertsen, B T

“…The wild-type tumor-suppressor gene TP53 encodes several isoforms of the p53 protein. However, while the role of p53 in controlling normal cell cycle…”
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The p53 isoform, Delta 133p53 alpha , stimulates angiogenesis and tumour progression by Bernard, H, Garmy-Susini, B, Ainaoui, N, Van Den Berghe, L, Peurichard, A, Javerzat, S, Bikfalvi, A, Lane, D P, Bourdon, J C, Prats, A-C

“…The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process…”
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The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer by Mao, X, Gauche, C, Coughtrie, M W H, Bui, C, Gulberti, S, Merhi-Soussi, F, Ramalanjaona, N, Bertin-Jung, I, Diot, A, Dumas, D, De Freitas Caires, N, Thompson, A M, Bourdon, J-C, Ouzzine, M, Fournel-Gigleux, S

“…Heparan sulfate (HS) proteoglycan chains are key components of the breast tumor microenvironment that critically influence the behavior of cancer cells. It is…”
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Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle by CHANG, Natasha C, NGUYEN, Mai, BOURDON, Johanne, RISSE, Paul-André, MARTIN, James, DANIALOU, Gawiyou, RIZZUTO, Rosario, PETROF, Basil J, SHORE, Gordon C

“…Nutrient-deprivation autophagy factor-1 (NAF-1) was identified as an endoplasmic reticulum (ER) BCL-2-interacting protein, which functions to mediate the…”
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Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation by Dichtel-Danjoy, M-L, Ma, D, Dourlen, P, Chatelain, G, Napoletano, F, Robin, M, Corbet, M, Levet, C, Hafsi, H, Hainaut, P, Ryoo, H D, Bourdon, J-C, Mollereau, B

“…Irradiated or injured cells enter apoptosis, and in turn, promote proliferation of surrounding unaffected cells. In Drosophila , apoptotic cells have an active…”
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Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma by Watt, S A, Pourreyron, C, Purdie, K, Hogan, C, Cole, C L, Foster, N, Pratt, N, Bourdon, J-C, Appleyard, V, Murray, K, Thompson, A M, Mao, X, Mein, C, Bruckner-Tuderman, L, Evans, A, McGrath, J A, Proby, C M, Foerster, J, Leigh, I M, South, A P

“…Identifying therapeutic targets for cancer treatment relies on consistent changes within particular types or sub-types of malignancy. The ability to define…”
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p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage by Aoubala, M, Murray-Zmijewski, F, Khoury, M P, Fernandes, K, Perrier, S, Bernard, H, Prats, A-C, Lane, D P, Bourdon, J-C

“…We have previously reported that the human p53 gene encodes at least nine different p53 isoforms, including Δ133p53 α , which can modulate p53 transcriptional…”
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Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity by Marcel, V, Petit, I, Murray-Zmijewski, F, Goullet de Rugy, T, Fernandes, K, Meuray, V, Diot, A, Lane, D P, Aberdam, D, Bourdon, J-C

“…In response to stress, p53 binds and transactivates the internal TP53 promoter, thus regulating the expression of its own isoform, Δ133p53 α . Here, we report…”
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Polychlorinated biphenyls (PCBs) contamination and aryl hydrocarbon receptor (AhR) agonist activity of Omega-3 polyunsaturated fatty acid supplements: Implications for daily intake of dioxins and PCBs by Bourdon, J.A., Bazinet, T.M., Arnason, T.T., Kimpe, L.E., Blais, J.M., White, P.A.

“…Omega-3 polyunsaturated fatty acid (n-3 PUFA) rich oils derived primarily from fish are frequently consumed as supplements. Due to the tendency of persistent…”
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p53 isoforms change p53 paradigm by Bourdon, JC

“…Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called…”
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p53 mutation, deprivation and poor prognosis in primary breast cancer by Baker, L, Quinlan, P R, Patten, N, Ashfield, A, Birse-Stewart-Bell, L-J, McCowan, C, Bourdon, J-C, Purdie, C A, Jordan, L B, Dewar, J A, Wu, L, Thompson, A M

“…Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53…”
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Scotin, a Novel p53-Inducible Proapoptotic Protein Located in the ER and the Nuclear Membrane by J.-C. Bourdon, Renzing, J., Robertson, P. L., Fernandes, K. N., Lane, D. P.

“…p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we…”
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Large-scale regulatory and signaling network assembly through linked open data by Lefebvre, M, Gaignard, A, Folschette, M, Bourdon, J, Guziolowski, C

“…Huge efforts are currently underway to address the organization of biological knowledge through linked open databases. These databases can be automatically…”
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