Search Results - "Bourass, J."

Synthesis of Aminocholesterol Derivatives with Antibiotic Properties by Elkihel, L., Bourass, J., Dherbomez, M., Letourneux, Y.

“…We report here a new family of antibiotic with fungicidal and antibacterial activity. The syntheses of five 7-amino and 7-aminoalkylcholesterol derivatives are…”
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Lymphotropic antifilarial agents derived from closantel and chlorambucil by Loiseau, P.M., Bourass, J., Letourneux, Y.

“…New closantel and chlorambucil prodrugs expected to accumulate in the lymphatic system were evaluated on the filaria Molinema dessetae. The prodrugs of…”
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STRUCTURE-ACTIVITY OF THREE PHOSPHOLIPID ANALOGUES TOWARDS INHIBITION OF PHOSPHOLIPASE A2 IN MACROPHAGES by LETOURNEUX, Y., BOURASS, J., BOUCROT, P., ELKIHEL, L., PETIT, J.Y.

“…At concentrations 1–20gmMin culture medium of rat peritoneal macrophages which were stimulated with ionophore A23187, the phospholipid analogues…”
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HIGH RATE OF INTESTINAL ABSORPTION OF THE PHOSPHOLIPID ANALOGUE 1-DODECYL 2-[1- 14C] OCTANAMIDO- sn-2-DEOXY-GLYCERO-3-PHOSPHOCHOLINE IN THE RAT by BOUCROT, P., BOURASS, J., ELKIHEL, L., LETOURNEUX, Y., GANDEMER, G.

“…The phospholipid analogue with two short fatty chains, 1-dodecyl-2-[1- 14C] octanamido- sn-2-deoxy-gly cero-3-phosphocholine ([ 14C] phospholipid analogue),…”
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DISSOCIATE ARACHIDONIC ACID RELEASE FROM EICOSANOID SYNTHESIS IN RAT PERITONEAL MACROPHAGES IS POSSIBLE USING CONCOMITANTLY EICOSAPENTANOIC ACID AS A PHOSPHOLIPID ANALOGUE by BOURASS, J., BOUCROT, P., LETOURNEUX, Y., GANDEMER, G., PETIT, J.Y.

“…Activated macrophages exposed to the association of eicosapentanoic acid 20:5 n-3 and a synthetic non hydrolysable phospholipid analogue maintained a discrete…”
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Studies on lipidomimetic derivatives of alpha-difluoromethylornithine (DFMO) to enhance the bioavailability in a Trypanosoma B. brucei murine trypanosomiasis model by Loiseau, P M, Czok, M, Chauffert, O, Bourass, J, Letourneux, Y

“…DFMO, a trypanostatic drug, presents a satisfactory intestinal absorption but its elimination from the blood is rapid so that high doses are necessary to…”
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Influence of alkyl chain lengths in dialkylglycerophosphocholines towards phospholipase A2 inhibition in macrophages by Letourneux, Y, Bourass, J, Elkihel, L, Boucrot, P, Petit, J Y, Welin, L

“…Rat peritoneal macrophages were cultured with a specific and potent phospholipase A2 activator A 23187, with 1-stearoyl-2-[3H]arachidonoyl-sn-GPC as source of…”
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Antileishmanial activity of rac-1-dodecyl-2-octanamido-2-deoxy-glycerophosphocholine, a new dialkylglycerophosphocholine, in vitro by Bourass, J, Loiseau, P M, Bories, C, Letourneux, Y

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Uptake of the phospholipase A2 inhibitor 1-dodecyl 2-[1-14C] octanamido-sn-2-deoxy glycero-3-phosphocholine by peritoneal macrophages by Bourass, J, Boucrot, P, Letourneux, Y, Gandemer, G, Petit, J Y

“…The [14C] phospholipid analogue 1-dodecyl-2-[1-14C] octanamido-sn-2-deoxy glycero-3-phosphocholine was synthetized. With 2 short fatty chains linked by alkyl…”
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Synthesis and orally macrofilaricidal evaluation of niclosamide lymphotropic prodrugs by Elkihel, L, Loiseau, P M, Bourass, J, Gayral, P, Letourneux, Y

“…The development of new macrofilaricidal drugs is described following a strategy for the promotion of the lymphatic transport of anthelminthic drugs by-passing…”
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High rate of intestinal absorption of the phospholipid anlaogue 1-dodecyl 2-[1-14C] octanamido-sn-2-deoxy-glycero-3-phosphocholine in the rat by Boucrot, P, Bourass, J, Elkihel, L, Letourneux, Y, Gandemer, G

“…The phospholipid analogue with two short fatty chains, 1-dodecyl-2-[1-14C] octanamido-sn-2-deoxy-glycero-3-phosphocholine ([14C] phospholipid analogue), with a…”
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Synthesis and evaluation of the anti-inflammatory effects of niflumic acid lipophilic prodrugs in brain edema by el Kihel, L, Bourass, J, Richomme, P, Petit, J Y, Letourneux, Y

“…Five new lipophilic prodrugs of the non-steroidal anti-inflammatory drug, niflumic acid (Nifluril, CAS 4394-00-7), were synthetized and evaluated on the…”
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