Search Results - "Bouma, Hjalmar R"

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI by van der Slikke, Elisabeth C, Star, Bastiaan S, van Meurs, Matijs, Henning, Robert H, Moser, Jill, Bouma, Hjalmar R

“…Sepsis is a life-threatening condition accompanied by organ dysfunction subsequent to a dysregulated host response to infection. Up to 60% of patients with…”
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Hibernation: the immune system at rest? by Bouma, Hjalmar R., Carey, Hannah V., Kroese, Frans G. M.

“…Review of mechanisms that might contribute to the fully reversible reduced immune function that is present during hibernation. Mammalian hibernation consists…”
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Unraveling the Big Sleep: Molecular Aspects of Stem Cell Dormancy and Hibernation by Dias, Itamar B, Bouma, Hjalmar R, Henning, Robert H

“…Tissue-resident stem cells may enter a dormant state, also known as quiescence, which allows them to withstand metabolic stress and unfavorable conditions…”
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Spatiotemporal regulation of hydrogen sulfide signaling in the kidney by Roorda, Maurits, Miljkovic, Jan Lj, van Goor, Harry, Henning, Robert H., Bouma, Hjalmar R.

“…Hydrogen sulfide (H2S) has long been recognized as a putrid, toxic gas. However, as a result of intensive biochemical research in the past two decades, H2S is…”
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Exploring the pathophysiology of post-sepsis syndrome to identify therapeutic opportunities by van der Slikke, Elisabeth C., An, Andy Y., Hancock, Robert E.W., Bouma, Hjalmar R.

“…Sepsis is a major health problem worldwide. As the number of sepsis cases increases, so does the number of sepsis survivors who suffer from “post-sepsis…”
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Hibernation and hemostasis by De Vrij, Edwin L, Bouma, Hjalmar R, Henning, Robert H, Cooper, Scott T

“…Hibernating mammals have developed many physiological adaptations to accommodate their decreased metabolism, body temperature, heart rate and prolonged…”
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The Novel Compound SUL-138 Counteracts Endothelial Cell and Kidney Dysfunction in Sepsis by Preserving Mitochondrial Function by Star, Bastiaan S, van der Slikke, Elisabeth C, van Buiten, Azuwerus, Henning, Robert H, Bouma, Hjalmar R

“…Sepsis is defined as a dysregulated host response leading to organ dysfunction, which may ultimately result in the patient's death. Mitochondrial dysfunction…”
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Hydrocortisone-associated death and hospital length of stay in patients with sepsis: A retrospective cohort of large-scale clinical care data by Li, Mohan, Noordam, Raymond, Winter, Elizabeth M., van Meurs, Matijs, Bouma, Hjalmar R., Arbous, M. Sesmu, Rensen, Patrick C.N., Kooijman, Sander

“…Sepsis is one of the leading causes of morbidity and mortality worldwide with approximately 50 million annual cases. There is ongoing debate on the clinical…”
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Dopamine treatment attenuates acute kidney injury in a rat model of deep hypothermia and rewarming – The role of renal H2S-producing enzymes by Dugbartey, George J., Talaei, Fatemeh, Houwertjes, Martin C., Goris, Maaike, Epema, Anne H., Bouma, Hjalmar R., Henning, Robert H.

“…Hypothermia and rewarming produces organ injury through the production of reactive oxygen species. We previously found that dopamine prevents hypothermia and…”
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Induction of torpor: Mimicking natural metabolic suppression for biomedical applications by Bouma, Hjalmar R., Verhaag, Esther M., Otis, Jessica P., Heldmaier, Gerhard, Swoap, Steven J., Strijkstra, Arjen M., Henning, Robert H., Carey, Hannah V.

“…Mammalian hibernation consists of periods of depressed metabolism and reduced body temperature called “torpor” that are interspersed by normothermic arousal…”
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Platelet dynamics during natural and pharmacologically induced torpor and forced hypothermia by de Vrij, Edwin L, Vogelaar, Pieter C, Goris, Maaike, Houwertjes, Martin C, Herwig, Annika, Dugbartey, George J, Boerema, Ate S, Strijkstra, Arjen M, Bouma, Hjalmar R, Henning, Robert H

“…Hibernation is an energy-conserving behavior in winter characterized by two phases: torpor and arousal. During torpor, markedly reduced metabolic activity…”
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Renal Mitochondrial Response to Low Temperature in Non-Hibernating and Hibernating Species by Dugbartey, George J, Hardenberg, Maarten C, Kok, Wendelinde F, Boerema, Ate S, Carey, Hannah V, Staples, James F, Henning, Robert H, Bouma, Hjalmar R

“…Therapeutic hypothermia is commonly applied to limit ischemic injury in organ transplantation, during cardiac and brain surgery and after cardiopulmonary…”
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Induction of a Torpor-Like State by 5'-AMP Does Not Depend on H2S Production by Dugbartey, George J, Bouma, Hjalmar R, Strijkstra, Arjen M, Boerema, Ate S, Henning, Robert H

“…Therapeutic hypothermia is used to reduce ischemia/reperfusion injury (IRI) during organ transplantation and major surgery, but does not fully prevent organ…”
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Predicting deterioration of patients with early sepsis at the emergency department using continuous heart rate variability analysis: a model-based approach by van Wijk, Raymond J, Quinten, Vincent M, van Rossum, Mathilde C, Bouma, Hjalmar R, Ter Maaten, Jan C

“…Sepsis is a life-threatening disease with an in-hospital mortality rate of approximately 20%. Physicians at the emergency department (ED) have to estimate the…”
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Intra-and inter-observer variability of point of care ultrasound measurements to evaluate hemodynamic parameters in healthy volunteers by Blanca, Deborah, Schwarz, Esther C., Olgers, Tycho Joan, ter Avest, Ewoud, Azizi, Nasim, Bouma, Hjalmar R., Ter Maaten, Jan Cornelis

“…Background Point-of-care ultrasound (POCUS) is a valuable tool for assessing the hemodynamic status of acute patients. Even though POCUS often uses a…”
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Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway by Talaei, Fatemeh, Bouma, Hjalmar R, Van der Graaf, Adrianus C, Strijkstra, Arjen M, Schmidt, Martina, Henning, Robert H

“…Biogenic amines have been demonstrated to protect cells from apoptotic cell death. Herein we show for the first time that serotonin and dopamine increase H(2)S…”
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Cecal Ligation and Puncture-Induced Sepsis Promotes Brown Adipose Tissue Inflammation Without Any Impact on Expression of Thermogenic-Related Genes by Moreno-Navarrete, José María, Comas, Ferran, de Jager, Vincent, Fernández-Real, José Manuel, Bouma, Hjalmar R.

“…Background and Aims: The negative effects of chronic low-level inflammation on adipose tissue physiology have been extensively demonstrated, whereas the…”
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Balancing Risks and Benefits: Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Diabetic Ketoacidosis by Kleinjan, Jan P, Blom, Justin, van Beek, André P, Bouma, Hjalmar R, van Dijk, Peter R

“…Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a new class of drugs that have been proven beneficial in the management of diabetes, chronic kidney…”
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Ensemble machine learning prediction and variable importance analysis of 5-year mortality after cardiac valve and CABG operations by Castela Forte, José, Mungroop, Hubert E., de Geus, Fred, van der Grinten, Maureen L., Bouma, Hjalmar R., Pettilä, Ville, Scheeren, Thomas W. L., Nijsten, Maarten W. N., Mariani, Massimo A., van der Horst, Iwan C. C., Henning, Robert H., Wiering, Marco A., Epema, Anne H.

“…Despite having a similar post-operative complication profile, cardiac valve operations are associated with a higher mortality rate compared to coronary artery…”
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GYY4137-Derived Hydrogen Sulfide Donates Electrons to the Mitochondrial Electron Transport Chain via Sulfide: Quinone Oxidoreductase in Endothelial Cells by Star, Bastiaan S, van der Slikke, Elisabeth C, Ransy, Céline, Schmitt, Alain, Henning, Robert H, Bouillaud, Frédéric, Bouma, Hjalmar R

“…The protective effects of hydrogen sulphide (H S) to limit oxidative injury and preserve mitochondrial function during sepsis, ischemia/reperfusion, and…”
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