Search Results - "Boulton, TG"
-
1
Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors
Published in Science (American Association for the Advancement of Science) (03-03-1995)“…Many members of the cytokine receptor superfamily initiate intracellular signaling by activating members of the Jak family of tyrosine kinases. Activation of…”
Get full text
Journal Article -
2
Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components
Published in Science (American Association for the Advancement of Science) (07-01-1994)“…A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and…”
Get full text
Journal Article -
3
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies
Published in Cell regulation (01-05-1991)“…A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-2 (MAP2) and myelin basic protein (MBP) is thought to play a…”
Get full text
Journal Article -
4
Extracellular signal-regulated kinases: ERKs in progress
Published in Cell regulation (01-12-1991)Get full text
Journal Article -
5
Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors
Published in The Journal of biological chemistry (15-04-1994)“…Ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL6) compose a family of distantly related…”
Get full text
Journal Article -
6
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF
Published in Cell (17-05-1991)“…We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting…”
Get more information
Journal Article -
7
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130
Published in Cell (26-06-1992)“…Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system. While some of the actions of leukemia inhibitory factor (LIF) on neurons…”
Get more information
Journal Article -
8
STAT3 Activation by Cytokines Utilizing gp130 and Related Transducers Involves a Secondary Modification Requiring an H7-Sensitive Kinase
Published in Proceedings of the National Academy of Sciences - PNAS (18-07-1995)“…Ciliary neurotrophic factor, oncostatin M, leukemiainhibitory factor, and interleukin 6 are related cytokines that initiate signaling by homodimerizing the…”
Get full text
Journal Article -
9
An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control
Published in Science (American Association for the Advancement of Science) (06-07-1990)“…A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-2 (MAP2), is thought to be an early intermediate in an…”
Get full text
Journal Article -
10
ERK3 Is a Constitutively Nuclear Protein Kinase (∗)
Published in The Journal of biological chemistry (12-04-1996)“…The ERK3 cDNA predicts a protein of 62,000 in size with a C-terminal domain that extends 180 amino acids beyond the conserved core of ERK family protein…”
Get full text
Journal Article -
11
Microtubule-Associated Protein 2 Kinases, ERK1 and ERK2, Undergo Autophosphorylation on Both Tyrosine and Threonine Residues: Implications for Their Mechanism of Activation
Published in Proceedings of the National Academy of Sciences - PNAS (15-07-1991)“…Microtubule-associated protein 2 kinase (MAP kinase), which exists in several forms, is a protein serine/threonine kinase that participates in a growth…”
Get full text
Journal Article -
12
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle
Published in Cell (11-02-1994)“…The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor…”
Get more information
Journal Article -
13
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase
Published in Biochemistry (Easton) (08-01-1991)“…In rat 1 fibroblasts, insulin has little or no stimulatory effect on the activities of either MAP2 protein kinase or ribosomal protein S6 kinase. In contrast,…”
Get full text
Journal Article -
14
Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest
Published in The EMBO journal (01-11-1992)“…Clam oocytes are arrested naturally at the G2/M border in meiosis and contain an inactive 42 kDa ERK/MAP kinase, p42MAPK. Following fertilization, p42MAPK is…”
Get full text
Journal Article -
15
Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta- phorbol 12-myristate 13-acetate-induced phosphorylation and activation
Published in The Journal of immunology (1950) (15-05-1992)“…Extracellular signal-regulated kinases (ERK) 1 and 2 are growth factor- and cytokine-sensitive serine/threonine kinases that are known to phosphorylate…”
Get full text
Journal Article -
16
Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs
Published in Biochemical and biophysical research communications (14-02-1992)“…Extracellular signal-regulated kinases 1 and 2 are growth factor-sensitive serine/threonine kinases. cDNAs for both human kinases were isolated and sequenced…”
Get more information
Journal Article -
17
Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activity
Published in The Journal of biological chemistry (13-09-1996)“…Despite the widespread use of polypeptide growth factors as pharmacological agents, little is known about the extent to which these molecules regulate their…”
Get full text
Journal Article -
18
An insulin-stimulated ribosomal protein S6 kinase from rabbit liver
Published in The Journal of biological chemistry (05-11-1989)“…In this report we describe an activated form of S6 protein kinase in rabbits treated acutely with insulin. The major insulin-stimulated activity in rabbit…”
Get full text
Journal Article -
19
Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid
Published in The Journal of biological chemistry (15-02-1990)“…The abilities of a series of six mutants of the human insulin receptor, an insulin receptor/v-ros hybrid (IR-ros) and the P68gag-ros transforming protein to…”
Get full text
Journal Article -
20
Neurotrophic factors, their receptors, and the signal transduction pathways they activate
Published in Cold Spring Harbor Symposia on Quantitative Biology (1990)“…Our studies of the spatiotemporal availability of neurotrophic factors, coupled with tagged ligand binding assays that identify cell bearing receptors for…”
Get more information
Journal Article