Search Results - "Boulton, TG"

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  1. 1

    Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors by Stahl, Neil, Farrugella, Thomas J., Boulton, Teri G., Zhong Zhong, Darnell, James E., Yancopoulos, George D.

    “…Many members of the cytokine receptor superfamily initiate intracellular signaling by activating members of the Jak family of tyrosine kinases. Activation of…”
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    Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies by Boulton, T G, Cobb, M H

    Published in Cell regulation (01-05-1991)
    “…A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-2 (MAP2) and myelin basic protein (MBP) is thought to play a…”
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    Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors by BOULTON, T. G, STAHL, N, YANCOPOULOS, G. D

    Published in The Journal of biological chemistry (15-04-1994)
    “…Ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL6) compose a family of distantly related…”
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    ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF by Boulton, Teri G, Nye, Steven H, Robbins, David J, Ip, Nancy Y, Radziejewska, Elizabeth, Morgenbesser, Sharon D, DePinho, Ronald A, Panayotatos, Nikos, Cobb, Melanie H, Yancopoulos, George D

    Published in Cell (17-05-1991)
    “…We recently described the purification and cloning of extracellular signal-regulated kinase 1 (ERK1), which appears to play a pivotal role in converting…”
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  7. 7

    CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130 by Ip, N Y, Nye, S H, Boulton, T G, Davis, S, Taga, T, Li, Y, Birren, S J, Yasukawa, K, Kishimoto, T, Anderson, D J

    Published in Cell (26-06-1992)
    “…Ciliary neurotrophic factor (CNTF) has a variety of actions within the nervous system. While some of the actions of leukemia inhibitory factor (LIF) on neurons…”
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  8. 8

    STAT3 Activation by Cytokines Utilizing gp130 and Related Transducers Involves a Secondary Modification Requiring an H7-Sensitive Kinase by Boulton, Teri G., Zhong Zhong, Wen, Zilong, Darnell, James E., Stahl, Neil, Yancopoulos, George D.

    “…Ciliary neurotrophic factor, oncostatin M, leukemiainhibitory factor, and interleukin 6 are related cytokines that initiate signaling by homodimerizing the…”
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  9. 9

    An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control by Boulton, Teri G., Yancopoulos, George D., Gregory, Jill S., Slaughter, Clive, Moomaw, Carolyn, Hsu, Joan, Cobb, Melanie H.

    “…A protein kinase characterized by its ability to phosphorylate microtubule-associated protein-2 (MAP2), is thought to be an early intermediate in an…”
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  10. 10

    ERK3 Is a Constitutively Nuclear Protein Kinase (∗) by Cheng, Mangeng, Boulton, Teri G., Cobb, Melanie H.

    Published in The Journal of biological chemistry (12-04-1996)
    “…The ERK3 cDNA predicts a protein of 62,000 in size with a C-terminal domain that extends 180 amino acids beyond the conserved core of ERK family protein…”
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    Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle by Helgren, Maureen E, Squinto, Stephen P, Davis, Heather L, Parry, David J, Boulton, Teri G, Heck, Carol S, Zhu, Yuan, Yancopoulos, George D, Lindsay, Ronald M, DiStefano, Peter S

    Published in Cell (11-02-1994)
    “…The actions and receptor for ciliary neurotrophic factor (CNTF) are largely restricted to cells of the nervous system, although one of the CNTF receptor…”
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  13. 13

    Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase by BOULTON, T. G, GREGORY, J. S, COBB, M. H

    Published in Biochemistry (Easton) (08-01-1991)
    “…In rat 1 fibroblasts, insulin has little or no stimulatory effect on the activities of either MAP2 protein kinase or ribosomal protein S6 kinase. In contrast,…”
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  14. 14

    Activation of p42 MAP kinase and the release of oocytes from cell cycle arrest by Shibuya, E.K., Boulton, T.G., Cobb, M.H., Ruderman, J.V.

    Published in The EMBO journal (01-11-1992)
    “…Clam oocytes are arrested naturally at the G2/M border in meiosis and contain an inactive 42 kDa ERK/MAP kinase, p42MAPK. Following fertilization, p42MAPK is…”
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    Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4 beta- phorbol 12-myristate 13-acetate-induced phosphorylation and activation by Whitehurst, CE, Boulton, TG, Cobb, MH, Geppert, TD

    Published in The Journal of immunology (1950) (15-05-1992)
    “…Extracellular signal-regulated kinases (ERK) 1 and 2 are growth factor- and cytokine-sensitive serine/threonine kinases that are known to phosphorylate…”
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    Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs by Owaki, H, Makar, R, Boulton, T G, Cobb, M H, Geppert, T D

    “…Extracellular signal-regulated kinases 1 and 2 are growth factor-sensitive serine/threonine kinases. cDNAs for both human kinases were isolated and sequenced…”
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  17. 17

    Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activity by DiStefano, P S, Boulton, T G, Stark, J L, Zhu, Y, Adryan, K M, Ryan, T E, Lindsay, R M

    Published in The Journal of biological chemistry (13-09-1996)
    “…Despite the widespread use of polypeptide growth factors as pharmacological agents, little is known about the extent to which these molecules regulate their…”
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  18. 18

    An insulin-stimulated ribosomal protein S6 kinase from rabbit liver by Gregory, J S, Boulton, T G, Sang, B C, Cobb, M H

    Published in The Journal of biological chemistry (05-11-1989)
    “…In this report we describe an activated form of S6 protein kinase in rabbits treated acutely with insulin. The major insulin-stimulated activity in rabbit…”
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  19. 19

    Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid by BOULTON, T. G, GREGORY, J. S, SONG-MUH JONG, LU-HAI WANG, ELLIS, L, COBB, M. H

    Published in The Journal of biological chemistry (15-02-1990)
    “…The abilities of a series of six mutants of the human insulin receptor, an insulin receptor/v-ros hybrid (IR-ros) and the P68gag-ros transforming protein to…”
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    Neurotrophic factors, their receptors, and the signal transduction pathways they activate by Yancopoulos, G D, Maisonpierre, P C, Ip, N Y, Aldrich, T H, Belluscio, L, Boulton, T G, Cobb, M H, Squinto, S P, Furth, M E

    “…Our studies of the spatiotemporal availability of neurotrophic factors, coupled with tagged ligand binding assays that identify cell bearing receptors for…”
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