Search Results - "Boulton, S. J."

Drug‐induced photosensitivity: new insights into pathomechanisms and clinical variation through basic and applied science by Khandpur, S., Porter, R.M., Boulton, S.J., Anstey, A.

“…Summary Drug‐induced photosensitivity occurs when a drug is capable of absorbing radiation from the sun (usually ultraviolet A) leading to chemical reactions…”
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Geomorphic and geological constraints on the active normal faulting of the Gediz (Alasehir) Graben, western Turkey by Kent, E, Boulton, Sarah J, Stewart, I. S, Whittaker, A. C, Alcicek, M. C

“…The Gediz (Alasehir) Graben is located in the highly tectonically active region of Western Turkey. Extension owing to regional geodynamic controls has resulted…”
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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing by Boulton, S.J, Jackson, S.P

“…In the budding yeast, Saccharomyces cerevisiae, genes in close proximity to telomeres are subject to transcriptional silencing through the process of telomere…”
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Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways by Boulton, S.J, Jackson, S.P

“…Ku, a heterodimer of polypeptides of approximately 70 kDa and 80 kDa (Ku70 and Ku80, respectively), binds avidly to DNA double-strand breaks (DSBs). Mammalian…”
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Transient fluvial incision as an indicator of active faulting and Plio-Quaternary uplift of the Moroccan High Atlas by Boulton, S.J., Stokes, M., Mather, A.E.

“…One of the challenges facing Earth Scientists is to determine the extent to which geomorphic features can be used to extract tectonic signals from landscapes…”
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Cellular functions of the BRCA tumour-suppressor proteins by Boulton, S J

“…Inherited germline mutations in either BRCA1 or BRCA2 confer a significant lifetime risk of developing breast or ovarian cancer. Defining how these two genes…”
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Holocene coastal notches in the Mediterranean region: Indicators of palaeoseismic clustering? by Boulton, S.J., Stewart, I.S.

“…Marine tidal notches are developed by bioerosion in the intertidal zones of rocky coasts, but a combination of sea-level change and crustal movements can…”
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MRE11 stability is regulated by CK2-dependent interaction with R2TP complex by von Morgen, P, Burdova, K, Flower, T G, O'Reilly, N J, Boulton, S J, Smerdon, S J, Macurek, L, Hořejší, Z

“…The MRN (MRE11–RAD50–NBS1) complex is essential for repair of DNA double-strand breaks and stalled replication forks. Mutations of the MRN complex subunit…”
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Temporal Variations in Landslide Distributions Following Extreme Events: Implications for Landslide Susceptibility Modeling by Jones, J. N., Boulton, S. J., Bennett, G. L., Stokes, M., Whitworth, M. R. Z.

“…Landslide susceptibility models are fundamental components of landslide risk management strategies. These models typically assume that landslide occurrence is…”
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From palaeotectonics to neotectonics in the Neotethys realm: The importance of kinematic decoupling and inherited structural grain in SW Anatolia (Turkey) by ten Veen, J.H., Boulton, S.J., Alçiçek, M.C.

“…In order to asses young, i.e. “neotectonic” fault kinematics and the relation with plate-tectonic processes in SW Turkey we focused on the questions: 1) what…”
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Constraining Historical Earthquake Sequences With Coulomb Stress Models: An Example From Western Türkiye by Diercks, M.‐L., Mildon, Z. K., Boulton, S. J., Hussain, E., Alçiçek, M. C., Yıldırım, C., Aykut, T.

“…Knowledge of earthquake source faults is crucial for the calculation of robust Coulomb stress models. However, source faults are often poorly constrained,…”
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A role for Ebi in neuronal cell cycle control by Boulton, Simon J., Brook, Adam, Staehling-Hampton, Karen, Heitzler, Pascal, Dyson, Nick

“…Mutations in ebi were isolated as enhancers of an over‐proliferation phenotype generated by elevated E2F/DP activity in the Drosophila eye. ebi alleles also…”
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Numerical modeling of tidal notch sequences on rocky coasts of the Mediterranean Basin by Schneiderwind, S., Boulton, S. J., Papanikolaou, I., Kázmér, M., Reicherter, K.

“…Tidal notches have had the potential to form at sea level from ~6.5 kyr B.P. in the Mediterranean Basin and preserve a symmetrical shape comparable to a…”
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Combined Functional Genomic Maps of the C. elegans DNA Damage Response by Boulton, Simon J., Gartner, Anton, Reboul, Jérôme, Vaglio, Philippe, Dyson, Nick, Hill, David E., Vidal, Marc

“…Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes…”
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Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis by Hofmann, E.Randal, Milstein, Stuart, Boulton, Simon J., Ye, Mianjia, Hofmann, Jen J., Stergiou, Lilli, Gartner, Anton, Vidal, Marc, Hengartner, Michael O.

“…Background: The inability to efficiently repair DNA damage or remove cells with severely damaged genomes has been linked to several human cancers. Studies in…”
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Identification of a Saccharomyces Cerevisiae Ku80 Homologue: Roles in DNA Double Strand Break Rejoining and in Telomeric Maintenance by Boulton, Simon J., Jackson, Stephen P.

“…Ku is a heterodimer of polypeptides of approximately 70 and 80 kDa (Ku70 and Ku80, respectively) that binds to DNA ends. Mammalian cells lacking Ku are…”
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BRCA1/BARD1 Orthologs Required for DNA Repair in Caenorhabditis elegans by Boulton, Simon J., Martin, Julie S., Polanowska, Jolanta, Hill, David E., Gartner, Anton, Vidal, Marc

“…Inherited germline mutations in the tumor suppressor gene BRCA1 predispose individuals to early onset breast and ovarian cancer [1]. BRCA1 together with its…”
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Yeast two‐hybrid systems and protein interaction mapping projects for yeast and worm by Walhout, Albertha J. M., Boulton, Simon J., Vidal, Marc

“…The availability of complete genome sequences necessitates the development of standardized functional assays to analyse the tens of thousands of predicted gene…”
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Controls on dryland mountain landscape development along the NW Saharan desert margin: Insights from Quaternary river terrace sequences (Dadès River, south-central High Atlas, Morocco) by Stokes, M., Mather, A.E., Belfoul, M., Faik, F., Bouzid, S., Geach, M.R., Cunha, P.P., Boulton, S.J., Thiel, C.

“…This study documents river terraces from upstream reaches of the Dadès River, a major fluvial system draining the south-central High Atlas Mountains. Terraces…”
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Innovative tidal notch detection using TLS and fuzzy logic: Implications for palaeo-shorelines from compressional (Crete) and extensional (Gulf of Corinth) tectonic settings by Schneiderwind, S., Boulton, S.J., Papanikolaou, I., Reicherter, K.

“…Tidal notches are a generally accepted sea-level marker and maintain particular interest for palaeoseismic studies since coastal seismic activity potentially…”
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