Search Results - "Boult, Jessica"

Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models by O'Connor, James P B, Boult, Jessica K R, Jamin, Yann, Babur, Muhammad, Finegan, Katherine G, Williams, Kaye J, Little, Ross A, Jackson, Alan, Parker, Geoff J M, Reynolds, Andrew R, Waterton, John C, Robinson, Simon P

“…There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring…”
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Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy by Mączyńska, Justyna, Raes, Florian, Da Pieve, Chiara, Turnock, Stephen, Boult, Jessica K R, Hoebart, Julia, Niedbala, Marcin, Robinson, Simon P, Harrington, Kevin J, Kaspera, Wojciech, Kramer-Marek, Gabriela

“…Surgical resection followed by chemo-radiation postpones glioblastoma (GBM) progression and extends patient survival, but these tumours eventually recur…”
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Monitoring the Vascular Response and Resistance to Sunitinib in Renal Cell Carcinoma In Vivo with Susceptibility Contrast MRI by Robinson, Simon P, Boult, Jessica K R, Vasudev, Naveen S, Reynolds, Andrew R

“…Antiangiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of antiangiogenic drugs to delay tumor progression and…”
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Exploring the biomechanical properties of brain malignancies and their pathologic determinants in vivo with magnetic resonance elastography by Jamin, Yann, Boult, Jessica K R, Li, Jin, Popov, Sergey, Garteiser, Philippe, Ulloa, Jose L, Cummings, Craig, Box, Gary, Eccles, Suzanne A, Jones, Chris, Waterton, John C, Bamber, Jeffrey C, Sinkus, Ralph, Robinson, Simon P

“…Malignant tumors are typically associated with altered rigidity relative to normal host tissue. Magnetic resonance elastography (MRE) enables the noninvasive…”
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Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography by Li, Jin, Zormpas-Petridis, Konstantinos, Boult, Jessica K R, Reeves, Emma L, Heindl, Andreas, Vinci, Maria, Lopes, Filipa, Cummings, Craig, Springer, Caroline J, Chesler, Louis, Jones, Chris, Bamber, Jeffrey C, Yuan, Yinyin, Sinkus, Ralph, Jamin, Yann, Robinson, Simon P

“…Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and metastasis. Therefore, stromal modulating therapies and accompanying…”
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Investigating the contribution of hyaluronan to the breast tumour microenvironment using multiparametric MRI and MR elastography by Reeves, Emma L., Li, Jin, Zormpas‐Petridis, Konstantinos, Boult, Jessica K. R., Sullivan, James, Cummings, Craig, Blouw, Barbara, Kang, David, Sinkus, Ralph, Bamber, Jeffrey C., Jamin, Yann, Robinson, Simon P.

“…Hyaluronan (HA) is a key component of the dense extracellular matrix in breast cancer, and its accumulation is associated with poor prognosis and metastasis…”
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Near‐infrared photoimmunotherapy targeting EGFR—Shedding new light on glioblastoma treatment by Burley, Thomas A., Mączyńska, Justyna, Shah, Anant, Szopa, Wojciech, Harrington, Kevin J., Boult, Jessica K.R., Mrozek‐Wilczkiewicz, Anna, Vinci, Maria, Bamber, Jeffrey C., Kaspera, Wojciech, Kramer‐Marek, Gabriela

“…Glioblastomas (GBMs) are high‐grade brain tumors, differentially driven by alterations (amplification, deletion or missense mutations) in the epidermal growth…”
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Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI by Boult, Jessica K.R., Box, Gary, Vinci, Maria, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.

“…Vascular endothelial growth factor A (VEGF-A) is considered one of the most important factors in tumor angiogenesis, and consequently, a number of therapeutics…”
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Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease by Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet C., Petrie, Kevin, Schwalbe, Ed C., Barker, Karen, Boult, Jessica K.R., Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra L., Poon, Evon, Robinson, Simon P., Ruddle, Ruth, Raynaud, Florence I., Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Ellison, David W., Wharton, Stephen B., Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas S., Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Weiss, William A., Chesler, Louis, Clifford, Steven C.

“…We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family…”
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Mapping Hypoxia in Renal Carcinoma with Oxygen-enhanced MRI: Comparison with Intrinsic Susceptibility MRI and Pathology by Little, Ross A, Jamin, Yann, Boult, Jessica K R, Naish, Josephine H, Watson, Yvonne, Cheung, Susan, Holliday, Katherine F, Lu, Huiqi, McHugh, Damien J, Irlam, Joely, West, Catharine M L, Betts, Guy N, Ashton, Garry, Reynolds, Andrew R, Maddineni, Satish, Clarke, Noel W, Parker, Geoff J M, Waterton, John C, Robinson, Simon P, O'Connor, James P B

“…Purpose To cross-validate T1-weighted oxygen-enhanced (OE) MRI measurements of tumor hypoxia with intrinsic susceptibility MRI measurements and to demonstrate…”
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Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling by Baker, Lauren CJ, Boult, Jessica KR, Thomas, Markus, Koehler, Astrid, Nayak, Tapan, Tessier, Jean, Ooi, Chia-Huey, Birzele, Fabian, Belousov, Anton, Zajac, Magdalena, Horn, Carsten, LeFave, Clare, Robinson, Simon P

“…Background: To assess antivascular effects, and evaluate clinically translatable magnetic resonance imaging (MRI) biomarkers of tumour response in vivo ,…”
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Correction: Triggering anti-GBM immune response with EGFR-mediated photoimmunotherapy by Mączyńska, Justyna, Raes, Florian, Da Pieve, Chiara, Turnock, Stephen, Boult, Jessica K R, Hoebart, Julia, Niedbala, Marcin, Robinson, Simon P, Harrington, Kevin J, Kaspera, Wojciech, Kramer-Marek, Gabriela

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Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging by Boult, Jessica K.R., Borri, Marco, Jury, Alexa, Popov, Sergey, Box, Gary, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.

“…High grade and metastatic brain tumours exhibit considerable spatial variations in proliferation, angiogenesis, invasion, necrosis and oedema. Vascular…”
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DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition by Izquierdo, Elisa, Carvalho, Diana M, Mackay, Alan, Temelso, Sara, Boult, Jessica K R, Pericoli, Giulia, Fernandez, Elisabet, Das, Molina, Molinari, Valeria, Grabovska, Yura, Rogers, Rebecca F, Ajmone-Cat, Maria Antonietta, Proszek, Paula Z, Stubbs, Mark, Depani, Sarita, O'Hare, Patricia, Yu, Lu, Roumelioti, Georgia, Choudhary, Jyoti S, Clarke, Matthew, Fairchild, Amy R, Jacques, Thomas S, Grundy, Richard G, Howell, Lisa, Picton, Susan, Adamski, Jenny, Wilson, Shaun, Gray, Juliet C, Zebian, Bassel, Marshall, Lynley V, Carceller, Fernando, Grill, Jacques, Vinci, Maria, Robinson, Simon P, Hubank, Michael, Hargrave, Darren, Jones, Chris

“…The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective…”
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Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform by Almeida, Gilberto S, Panek, Rafal, Hallsworth, Albert, Webber, Hannah, Papaevangelou, Efthymia, Boult, Jessica KR, Jamin, Yann, Chesler, Louis, Robinson, Simon P

“…Background: The use of clinical MRI scanners to conduct pre-clinical research facilitates comparisons with clinical studies. Here the utility and sensitivity…”
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Noninvasive MRI Native T1 Mapping Detects Response to MYCN -targeted Therapies in the Th- MYCN Model of Neuroblastoma by Zormpas-Petridis, Konstantinos, Poon, Evon, Clarke, Matthew, Jerome, Neil P., Boult, Jessica K.R., Blackledge, Matthew D., Carceller, Fernando, Koers, Alexander, Barone, Giuseppe, Pearson, Andrew D.J., Moreno, Lucas, Anderson, John, Sebire, Neil, McHugh, Kieran, Koh, Dow-Mu, Chesler, Louis, Yuan, Yinyin, Robinson, Simon P., Jamin, Yann

“…Abstract Noninvasive early indicators of treatment response are crucial to the successful delivery of precision medicine in children with cancer. Neuroblastoma…”
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Non-invasive in vivo imaging of vessel calibre in orthotopic prostate tumour xenografts by Walker-Samuel, Simon, Boult, Jessica K.R., McPhail, Lesley D., Box, Gary, Eccles, Suzanne A., Robinson, Simon P.

“…Susceptibility contrast magnetic resonance imaging (MRI), utilising ultrasmall superparamagnetic iron oxide (USPIO) particles, was evaluated for the…”
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Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma by Al-Saffar, Nada M. S., Troy, Helen, Wong Te Fong, Anne-Christine, Paravati, Roberta, Jackson, L. Elizabeth, Gowan, Sharon, Boult, Jessica K. R., Robinson, Simon P., Eccles, Suzanne A., Yap, Timothy A., Leach, Martin O., Chung, Yuen-Li

“…Background AKT is commonly overexpressed in tumours and plays an important role in the metabolic reprogramming of cancer. We have used magnetic resonance…”
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Assessment of the direct effects of DDAH I on tumour angiogenesis in vivo by Papaevangelou, Efthymia, Boult, Jessica K. R., Whitley, Guy S., Robinson, Simon P., Howe, Franklyn A.

“…Nitric oxide (NO) has been strongly implicated in glioma progression and angiogenesis. The endogenous inhibitors of NO synthesis, asymmetric dimethylarginine…”
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Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues by Khan, Aadil A, Paget, James T, McLaughlin, Martin, Kyula, Joan N, Wilkinson, Michelle J, Pencavel, Timothy, Mansfield, David, Roulstone, Victoria, Seth, Rohit, Halle, Martin, Somaiah, Navita, Boult, Jessica K R, Robinson, Simon P, Pandha, Hardev S, Vile, Richard G, Melcher, Alan A, Harris, Paul A, Harrington, Kevin J

“…Improvements in cancer survival mean that long-term toxicities, which contribute to the morbidity of cancer survivorship, are being increasingly recognized…”
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