Search Results - "Boult, J K R"

Tumour biomechanical response to the vascular disrupting agent ZD6126 in vivo assessed by magnetic resonance elastography by Li, J, Jamin, Y, Boult, J K R, Cummings, C, Waterton, J C, Ulloa, J, Sinkus, R, Bamber, J C, Robinson, S P

“…Background: Magnetic resonance elastography (MRE) is an emerging imaging technique that affords non-invasive quantitative assessment and visualization of…”
Get full text

Dichloroacetate induces autophagy in colorectal cancer cells and tumours by Lin, G, Hill, D K, Andrejeva, G, Boult, J K R, Troy, H, Fong, A-C L F W T, Orton, M R, Panek, R, Parkes, H G, Jafar, M, Koh, D-M, Robinson, S P, Judson, I R, Griffiths, J R, Leach, M O, Eykyn, T R, Chung, Y-L

“…Background: Dichloroacetate (DCA) has been found to have antitumour properties. Methods: We investigated the cellular and metabolic responses to DCA treatment…”
Get full text

Threshold for epileptiform activity is elevated in prion knockout mice by Ratté, S, Vreugdenhil, M, Boult, J.K.R, Patel, A, Asante, E.A, Collinge, J, Jefferys, J.G.R

“…Abstract Prion protein (PrP) is abundant in the nervous system, but its role remains uncertain. Prion diseases depend on an aggregation of the protein that is…”
Get full text

Oesophageal adenocarcinoma is associated with a deregulation in the MYC MAX MAD network by Boult, J K R, Tanière, P, Hallissey, M T, Campbell, M J, Tselepis, C

“…Oesophageal adenocarcinoma, which arises from an acquired columnar lesion, Barrett's metaplasia, is rising in incidence more rapidly than any other cancer in…”
Get full text

SHH pathway inhibition is protumourigenic in adamantinomatous craniopharyngioma by Carreno, G, Boult, J K R, Apps, J, Gonzalez-Meljem, J M, Haston, S, Guiho, R, Stache, C, Danielson, L S, Koers, A, Smith, L M, Virasami, A, Panousopoulos, L, Buchfelder, M, Jacques, T S, Chesler, L, Robinson, S P, Martinez-Barbera, J P

“…Pharmacological inhibition of the sonic hedgehog (SHH) pathway can be beneficial against certain cancers but detrimental in others. Adamantinomatous…”
Get full text

The role of tumour-derived iNOS in tumour progression and angiogenesis by Kostourou, V, Cartwright, J E, Johnstone, A P, Boult, J K R, Cullis, E R, Whitley, GStJ, Robinson, S P

“…Background: Progressive tumour growth is dependent on the development of a functional tumour vasculature and highly regulated by growth factors and cytokines…”
Get full text

The HIF-pathway inhibitor NSC-134754 induces metabolic changes and anti-tumour activity while maintaining vascular function by Baker, L C J, Boult, J K R, Walker-Samuel, S, Chung, Y-L, Jamin, Y, Ashcroft, M, Robinson, S P

“…Background: Hypoxia-inducible factor-1 (HIF-1) mediates the transcriptional response to hypoxic stress, promoting tumour progression and survival. This study…”
Get full text

False-negative MRI biomarkers of tumour response to targeted cancer therapeutics by Boult, J K R, Jamin, Y, Jacobs, V, Gilmour, L D, Walker-Samuel, S, Halliday, J, Elvin, P, Ryan, A J, Waterton, J C, Robinson, S P

“…Background: Non-invasive quantitative imaging biomarkers are essential for the evaluation of novel targeted therapeutics. Before deployment in clinical trials,…”
Get full text