Biosafety standards for working with Crimean-Congo hemorrhagic fever virus

In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafe...

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Bibliographic Details
Published in:	Journal of general virology Vol. 97; no. 11; pp. 2799 - 2808
Main Authors:	Weidmann, Manfred, Avsic-Zupanc, Tatjana, Bino, Silvia, Bouloy, Michelle, Burt, Felicity, Chinikar, Sadegh, Christova, Iva, Dedushaj, Isuf, El-Sanousi, Ahmed, Elaldi, Nazif, Hewson, Roger, Hufert, Frank T, Humolli, Isme, Jansen van Vuren, Petrus, Koçak Tufan, Zeliha, Korukluoglu, Gülay, Lyssen, Pieter, Mirazimi, Ali, Neyts, Johan, Niedrig, Matthias, Ozkul, Aykut, Papa, Anna, Paweska, Janusz, Sall, Amadou A, Schmaljohn, Connie S, Swanepoel, Robert, Uyar, Yavuz, Weber, Friedemann, Zeller, Herve
Format:	Journal Article
Language:	English
Published:	England 01-11-2016
Subjects:	Animals Bunyaviridae Containment of Biohazards - standards Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever Virus, Crimean-Congo - immunology Hemorrhagic Fever Virus, Crimean-Congo - physiology Hemorrhagic Fever, Crimean - prevention & control Hemorrhagic Fever, Crimean - virology Humans Medicin och hälsovetenskap Occupational Exposure - prevention & control Occupational Exposure - standards
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Summary:	In countries from which Crimean-Congo haemorrhagic fever (CCHF) is absent, the causative virus, CCHF virus (CCHFV), is classified as a hazard group 4 agent and handled in containment level (CL)-4. In contrast, most endemic countries out of necessity have had to perform diagnostic tests under biosafety level (BSL)-2 or -3 conditions. In particular, Turkey and several of the Balkan countries have safely processed more than 100 000 samples over many years in BSL-2 laboratories. It is therefore advocated that biosafety requirements for CCHF diagnostic procedures should be revised, to allow the tests required to be performed under enhanced BSL-2 conditions with appropriate biosafety laboratory equipment and personal protective equipment used according to standardized protocols in the countries affected. Downgrading of CCHFV research work from CL-4, BSL-4 to CL-3, BSL-3 should also be considered.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1317 1465-2099 1465-2099
DOI:	10.1099/jgv.0.000610