Search Results - "Boulnois, G"

The Role of Pneumolysin and Autolysin in the Pathology of Pneumonia and Septicemia in Mice Infected with a Type 2 Pneumococcus by Canvin, James R., Marvin, Andrew P., Sivakumaran, Muttuswamy, Paton, James C., Boulnois, Graham J., Andrew, Peter W., Mitchell, Timothy J.

“…Mice were infected intranasally with a serotype 2 pneumococcus, a pneumolysin-negative derivative (PLN-A), or an autolysin-negative derivative (AL-2). Numbers…”
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A neuraminidase from Streptococcus pneumoniae has the features of a surface protein by CAMARA, M, BOULNOIS, G. J, ANDREW, P. W, MITCHELL, T. J

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Molecular analysis of the pathogenicity of Streptococcus pneumoniae : the role of pneumococcal proteins by PATON, J. C, ANDREW, P. W, BOULNOIS, G. J, MITCHELL, T. J

“…For many years the virulence of Streptococcus pneumoniae has largely been attributed to its antiphagocytic polysaccharide capsule. Recent evidence, however,…”
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Structure and function of pneumolysin, the multifunctional, thiol-activated toxin of Streptococcus pneumoniae by Boulnois, G J, Paton, J C, Mitchell, T J, Andrew, P W

“…Pneumolysin is a thiol-activated, membrane-damaging, multifunctional toxin and a known virulence factor of Streptococcus pneumoniae. The toxin can interfere…”
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Complement activation and antibody binding by pneumolysin via a region of the toxin homologous to a human acute-phase protein by Mitchell, T J, Andrew, P W, Saunders, F K, Smith, A N, Boulnois, G J

“…Pneumolysin, a membrane-damaging toxin, is known to activate the classical complement pathway. We have shown that 1 microgram ml-1 of pneumolysin can activate…”
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NZB Mouse System for Production of Monoclonal Antibodies to Weak Bacterial Antigens: Isolation of an IgG Antibody to the Polysaccharide Capsules of Escherichia coli K1 and Group B Meningococci by Frosch, Matthias, Gorgen, Ingrid, Boulnois, Graham J., Timmis, Kenneth N., Bitter-Suermann, Dieter

“…A system for the production of monoclonal antibodies, particularly of the IgG type, against weakly immunogenic bacterial polysaccharide antigens is described…”
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Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide by PATON, J. C, LOCK, R. A, CHI-JEN LEE, LI, J. P, BERRY, A. M, MITCHELL, T. J, ANDREW, P. W, HANSMAN, D, BOULNOIS, G. J

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Molecular analysis of region 1 of the Escherichia coli K5 antigen gene cluster: a region encoding proteins involved in cell surface expression of capsular polysaccharide by PAZZANI, C, ROSENOW, C, BOULNOIS, G. J, BRONNER, D, JANN, K, ROBERTS, I. S

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Expression of the capsular K5 polysaccharide of Escherichia coli: biochemical and electron microscopic analyses of mutants with defects in region 1 of the K5 gene cluster by BRONNER, D, SIEBERTH, V, PAZZANI, C, ROBERTS, I. S, BOULNOIS, G. J, JANN, B, JANN, K

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Molecular analysis of the Escherichia coli K5 kps locus: identification and characterization of an inner-membrane capsular polysaccharide transport system by Smith, A N, Boulnois, G J, Roberts, I S

“…The complete nucleotide sequence has been determined of a region of the Escherichia coli K5 antigen gene cluster postulated to encode functions for the…”
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Drug discovery in the new millennium: the pivotal role of biotechnology by Boulnois, Graham J

“…Biotechnology has made, and will continue to make, a major contribution to the health of mankind by providing new insights into disease and acting as a pivotal…”
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Molecular cloning, characterization, and complete nucleotide sequence of the gene for pneumolysin, the sulfhydryl-activated toxin of Streptococcus pneumoniae by Walker, J A, Allen, R L, Falmagne, P, Johnson, M K, Boulnois, G J

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Genetics of capsular polysaccharide production in bacteria by Boulnois, G J, Roberts, I S

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Nucleotide sequence of the streptolysin O (SLO) gene: structural homologies between SLO and other membrane-damaging, thiol-activated toxins by KEHOE, M. A, MILLER, L, WALKER, J. A, BOULNOIS, G. J

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Common organization of gene clusters for production of different capsular polysaccharides (K antigens) in Escherichia coli by ROBERTS, I. S, MOUNTFORD, R, HODGE, R, JANN, K. B, BOULNOIS, G. J

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Development of a PCR probe test for identifying Pseudomonas aeruginosa and Pseudomonas (Burkholderia) cepacia by O'Callaghan, E M, Tanner, M S, Boulnois, G J

“…AIMS--To develop a system of species specific polymerase chain reaction (PCR) and DNA hybridisation based on 16s ribosomal RNA sequences for the identification…”
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A highly conserved repeated DNA element located in the chromosome of Streptococcus pneumoniae by MARTIN, B, HUMBERT, O, MORRISON, D. A, BOULNOIS, G. J, CLAVERYS, J.-P, CAMARA, M, GUENZI, E, WALKER, J, MITCHELL, T, ANDREW, P, PRUDHOMME, M, ALLOING, G, HAKENBECK, R

“…We report the discovery of a group of highly conserved DNA sequences located, in those cases studied, within intergenic regions of the chromosome of the Gram…”
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Pneumolysin, the thiol-activated toxin of Streptococcus pneumoniae, does not require a thiol group for in vitro activity by SAUNDERS, F. K, MITCHELL, T. J, WALKER, J. A, ANDREW, P. W, BOULNOIS, G. J

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Bacterial polysaccharide capsule synthesis, export and evolution of structural diversity by Boulnois, G J, Jann, K

“…Elaboration of a capsule composed of one of a range of acidic polysaccharides is a common feature of many bacteria, particularly those capable of causing…”
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Molecular cloning and analysis of genes for sialic acid synthesis in Neisseria meningitidis group B and purification of the meningococcal CMP-NeuNAc synthetase enzyme by GANGULI, S, ZAPATA, G, WALLIS, T, REID, C, BOULNOIS, G, VANN, W. F, ROBERTS, I. S

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