Nanoceria as Safe Contrast Agents for X-ray CT Imaging

Cerium oxide nanoparticles (CeO NPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce ato...

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Bibliographic Details
Published in:	Nanomaterials (Basel, Switzerland) Vol. 13; no. 15; p. 2208
Main Authors:	García, Ana, Cámara, Juan Antonio, Boullosa, Ana María, Gustà, Muriel F, Mondragón, Laura, Schwartz, Jr, Simó, Casals, Eudald, Abasolo, Ibane, Bastús, Neus G, Puntes, Víctor
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29-07-2023 MDPI
Subjects:	Analysis Biocompatibility Biodistribution CeO2 nanoparticles Cerium Cerium oxides Computed tomography Contrast agents Contrast media CT imaging DNA damage Evolution Free radicals Injection Iodine Kidneys Liver Lymphatic system Mass spectrometry Mass spectroscopy Medical imaging nanoceria Nanoparticles Oxides Properties Quantitative analysis Radiation Radiation damage Radiation effects Reactive oxygen species reactive oxygen species scavengers Spleen Toxicity Tumors Veins & arteries X ray imagery X-ray CT imaging X-rays Spain X-ray CT imaging reactive oxygen species scavengers CeO2 nanoparticles nanoceria
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Summary:	Cerium oxide nanoparticles (CeO NPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce atom's high Z number makes it an ideal candidate for utilisation as an X-ray imaging contrast agent. We herein show how the injection of albumin-stabilised 5 nm CeO NPs into mice revealed substantial enhancement in X-ray contrast, reaching up to a tenfold increase at significantly lower concentrations than commercial or other proposed contrast agents. Remarkably, these NPs exhibited prolonged residence time within the target organs. Thus, upon injection into the tail vein, they exhibited efficient uptake by the liver and spleen, with 85% of the injected dose (%ID) recovered after 7 days. In the case of intratumoral administration, 99% ID of CeO NPs remained within the tumour throughout the 7-day observation period, allowing for observation of disease dynamics. Mass spectrometry (ICP-MS) elemental analysis confirmed X-ray CT imaging observations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2079-4991 2079-4991
DOI:	10.3390/nano13152208