Search Results - "Boulet, Sabrina"

A metabolic biomarker predicts Parkinson's disease at the early stages in patients and animal models by Mallet, David, Dufourd, Thibault, Decourt, Mélina, Carcenac, Carole, Bossù, Paola, Verlin, Laure, Fernagut, Pierre-Olivier, Benoit-Marand, Marianne, Spalletta, Gianfranco, Barbier, Emmanuel L, Carnicella, Sebastien, Sgambato, Véronique, Fauvelle, Florence, Boulet, Sabrina

“…BackgroundCare management of Parkinson's disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the…”
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Pramipexole restores behavioral inhibition in highly impulsive rats through a paradoxical modulation of frontostriatal networks by Magnard, Robin, Fouyssac, Maxime, Vachez, Yvan M., Cheng, Yifeng, Dufourd, Thibault, Carcenac, Carole, Boulet, Sabrina, Janak, Patricia H., Savasta, Marc, Belin, David, Carnicella, Sebastien

“…Impulse control disorders (ICDs), a wide spectrum of maladaptive behaviors which includes pathological gambling, hypersexuality and compulsive buying, have…”
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Dopamine gene therapy for Parkinson's disease in a nonhuman primate without associated dyskinesia by Jarraya, Béchir, Boulet, Sabrina, Ralph, G Scott, Jan, Caroline, Bonvento, Gilles, Azzouz, Mimoun, Miskin, James E, Shin, Masahiro, Delzescaux, Thierry, Drouot, Xavier, Hérard, Anne-Sophie, Day, Denise M, Brouillet, Emmanuel, Kingsman, Susan M, Hantraye, Philippe, Mitrophanous, Kyriacos A, Mazarakis, Nicholas D, Palfi, Stéphane

“…In Parkinson's disease, degeneration of specific neurons in the midbrain can cause severe motor deficits, including tremors and the inability to initiate…”
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Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease by Magnard, Robin, Vachez, Yvan, Carcenac, Carole, Boulet, Sabrina, Houeto, Jean-Luc, Savasta, Marc, Belin, David, Carnicella, Sebastien

“…Impulse control disorders (ICDs) are frequent behavioral complications of dopaminergic (DA) replacement therapies (DRTs) in Parkinson's disease (PD). Impulsive…”
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Behavioral Recovery in MPTP-Treated Monkeys: Neurochemical Mechanisms Studied by Intrastriatal Microdialysis by Boulet, Sabrina, Mounayar, Stephanie, Poupard, Annie, Bertrand, Anne, Jan, Caroline, Pessiglione, Mathias, Hirsch, Etienne C, Feuerstein, Claude, Francois, Chantal, Feger, Jean, Savasta, Marc, Tremblay, Leon

“…Parkinson's disease (PD) patients express motor symptoms only after 60-80% striatal dopamine (DA) depletion. The presymptomatic phase of the disease may be…”
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Subthalamic Stimulation-Induced Forelimb Dyskinesias Are Linked to an Increase in Glutamate Levels in the Substantia Nigra Pars Reticulata by Boulet, Sabrina, Lacombe, Emilie, Carcenac, Carole, Feuerstein, Claude, Sgambato-Faure, Veronique, Poupard, Annie, Savasta, Marc

“…The neurobiological mechanisms by which high-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates the motor symptoms of Parkinson's disease…”
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High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats by Lacombe, Emilie, Carcenac, Carole, Boulet, Sabrina, Feuerstein, Claude, Bertrand, Anne, Poupard, Annie, Savasta, Marc

“…High‐frequency stimulation of the subthalamic nucleus (STN‐HFS) is a powerful approach for treating the motor symptoms of Parkinson's disease (PD). It results…”
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IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates by Aron Badin, Romina, Spinnewyn, Brigitte, Gaillard, Marie-Claude, Jan, Caroline, Malgorn, Carole, Van Camp, Nadja, Dollé, Frédéric, Guillermier, Martine, Boulet, Sabrina, Bertrand, Anne, Savasta, Marc, Auguet, Michel, Brouillet, Emmanuel, Chabrier, Pierre-Etienne, Hantraye, Philippe

“…The development of dyskinesias following chronic L-DOPA replacement therapy remains a major problem in the long-term treatment of Parkinson's disease. This…”
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Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use by Goutaudier, Raphaël, Joly, Fanny, Mallet, David, Bartolomucci, Magali, Guicherd, Denis, Carcenac, Carole, Vossier, Frédérique, Dufourd, Thibault, Boulet, Sabrina, Deransart, Colin, Chovelon, Benoit, Carnicella, Sebastien

“…The neurobiological mechanisms underlying compulsive alcohol use, a cardinal feature of alcohol use disorder, remain elusive. The key modulator of motivational…”
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Loss of dopaminergic nigrostriatal neurons accounts for the motivational and affective deficits in Parkinson’s disease by Drui, G, Carnicella, S, Carcenac, C, Favier, M, Bertrand, A, Boulet, S, Savasta, M

“…Parkinson’s disease (PD) involves the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) that is thought to cause the…”
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Re-routing Metabolism by the Mitochondrial Pyruvate Carrier Inhibitor MSDC-0160 Attenuates Neurodegeneration in a Rat Model of Parkinson’s Disease by Mallet, David, Goutaudier, Raphael, Barbier, Emmanuel L., Carnicella, Sebastien, Colca, Jerry R., Fauvelle, Florence, Boulet, Sabrina

“…A growing body of evidence supports the idea that mitochondrial dysfunction might represent a key feature of Parkinson’s disease (PD). Central regulators of…”
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Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease by Vachez, Yvan, Carcenac, Carole, Magnard, Robin, Kerkerian‐Le Goff, Lydia, Salin, Pascal, Savasta, Marc, Carnicella, Sebastien, Boulet, Sabrina

“…Background Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under…”
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Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats by Carcenac, Carole, Favier, Mathieu, Vachez, Yvan, Lacombe, Emilie, Carnicella, Sébastien, Savasta, Marc, Boulet, Sabrina

“…High‐frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment for the motor symptoms of Parkinson's disease (PD),…”
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Reply to: Letter to the Editor by Martínez‐Fernández by Vachez, Yvan, Carcenac, Carole, Magnard, Robin, Goff, Lydia Kerkerian‐le, Salin, Pascal, Savasta, Marc, Carnicella, Sebastien, Boulet, Sabrina

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Subthalamic Nucleus Stimulation Impairs Motivation: Implication for Apathy in Parkinson's Disease by Vachez, Yvan, Carcenac, Carole, Magnard, Robin, Kerkerian-Le Goff, Lydia, Salin, Pascal, Savasta, Marc, Carnicella, Sebastien, Boulet, Sabrina

“…Background: Apathy is one of the most disabling neuropsychiatric symptoms in Parkinson's disease (PD) patients and has a higher prevalence in patients under…”
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Implication of dorsostriatal D3 receptors in motivational processes: a potential target for neuropsychiatric symptoms in Parkinson’s disease by Favier, Mathieu, Carcenac, Carole, Drui, Guillaume, Vachez, Yvan, Boulet, Sabrina, Savasta, Marc, Carnicella, Sebastien

“…Beyond classical motor symptoms, motivational and affective deficits are frequently observed in Parkinson’s disease (PD), dramatically impairing the quality of…”
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A metabolic biomarker predicts Parkinson's disease at the early stages in patients and animal models by Mallet, David, Dufourd, Thibault, Decourt, Mélina, Carcenac, Carole, Bossů, Paola, Verlin, Laure, Fernagut, Pierre-Olivier, Benoit-Marand, Marianne, Spalletta, Gianfranco, Barbier, Emmanuel L, Carnicella, Sebastien, Sgambato, Véronique, Fauvelle, Florence, Boulet, Sabrina

“…BACKGROUND. Care management of Parkinsons disease (PD) patients currently remains symptomatic, mainly because diagnosis relying on the expression of the…”
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Reply to: Letter to the Editor by Martínez‐Fernández by Vachez, Yvan, Carcenac, Carole, Magnard, Robin, Goff, Lydia Kerkerian‐Le, Salin, Pascal, Savasta, Marc, Carnicella, Sebastien, Boulet, Sabrina

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Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers by Dufourd, Thibault, Robil, Noémie, Mallet, David, Carcenac, Carole, Boulet, Sabrina, Brishoual, Sonia, Rabois, Emilie, Houeto, Jean-Luc, de la Grange, Pierre, Carnicella, Sebastien

“…microRNAs are small non-coding RNAs gaining interest for their potential roles as reliable biomarkers for the diagnosis and therapeutics of numerous…”
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High-frequency stimulation of the subthalamic nucleus modifies the expression of vesicular glutamate transporters in basal ganglia in a rat model of Parkinson's disease by Favier, Mathieu, Carcenac, Carole, Drui, Guillaume, Boulet, Sabrina, El Mestikawy, Salah, Savasta, Marc

“…It has been suggested that glutamatergic system hyperactivity may be related to the pathogenesis of Parkinson's disease (PD). Vesicular glutamate transporters…”
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