Search Results - "Boulet, Inge R."

Role of the S6 C-terminus in KCNQ1 channel gating by Boulet, Inge R., Labro, Alain J., Raes, Adam L., Snyders, Dirk J.

“…Co-assembly of KCNQ1 α-subunits with KCNE1 β-subunits results in the channel complex underlying the cardiac I Ks current in vivo . Like other voltage-gated K…”
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The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure by Labro, Alain J., Boulet, Inge R., Choveau, Frank S., Mayeur, Evy, Bruyns, Tine, Loussouarn, Gildas, Raes, Adam L., Snyders, Dirk J.

“…In vivo, KCNQ1 α-subunits associate with the β-subunit KCNE1 to generate the slowly activating cardiac potassium current (IKs). Structurally, they share their…”
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Dominant-Negative Control of cAMP-Dependent IKs Upregulation in Human Long-QT Syndrome Type 1 by Heijman, Jordi, Spätjens, Roel L.H.M.G, Seyen, Sandrine R.M, Lentink, Viola, Kuijpers, Helma J.H, Boulet, Inge R, de Windt, Leon J, David, Miren, Volders, Paul G.A

“…RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K (IKs) channel, predisposes to…”
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The rate-dependent biophysical properties of the LQT1 H258R mutant are counteracted by a dominant negative effect on channel trafficking by Labro, Alain J, Boulet, Inge R, Timmermans, Jean-Pierre, Ottschytsch, Natacha, Snyders, Dirk J

“…Abstract The long QT syndrome (LQTS) is a cardiac disorder caused by a prolonged ventricular repolarization. The co-assembly of the pore-forming human KCNQ1…”
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Functional effects of a KCNQ1 mutation associated with the long QT syndrome by BOULET, Inge R, RAES, Adam L, OTTSCHYTSCH, Natacha, SNYDERS, Dirk J

“…Long QT syndrome (LQTS) is an inherited disorder of ventricular repolarization caused by mutations in cardiac ion channel genes, including KCNQ1. In this study…”
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Dominant-Negative Control of cAMP-Dependent I Ks Upregulation in Human Long-QT Syndrome Type 1 by Heijman, Jordi, Spätjens, Roel L.H.M.G., Seyen, Sandrine R.M., Lentink, Viola, Kuijpers, Helma J.H., Boulet, Inge R., de Windt, Leon J., David, Miren, Volders, Paul G.A.

“…Rationale: The mutation A341V in the S6 transmembrane segment of KCNQ1 , the α-subunit of the slowly activating delayed-rectifier K + (I Ks ) channel,…”
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The LQT1 Phenotype of the KCNQ1 H258R Mutant is Unmasked by Faster Stimulation Rates by Labro, Alain J., Boulet, Inge R., Mayeur, Evy, Timmermans, Jean-Pierre, Snyders, Dirk J.

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Substitution Scan of the S4-S5 Linker Region in KCNQ1 Channel: Structural Scaffold for Critical Protein Interactions by Labro, Alain J., Boulet, Inge R., Raes, Adam L., Snyders, Dirk J.

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Structure and function analysis of the KCNQ1 channel in relation to the LQT1 syndrome by Boulet, Inge R

“…Voltage gated potassium channels are comprised of four subunits, each subunit contains 6 transmembrane helices. These channels open and close upon…”
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