Search Results - "Boularès, A."

Repurposing ketoconazole as an exosome directed adjunct to sunitinib in treating renal cell carcinoma by Greenberg, Jacob W., Kim, Hogyoung, Moustafa, Ahmed A., Datta, Amrita, Barata, Pedro C., Boulares, A. Hamid, Abdel-Mageed, Asim B., Krane, Louis S.

“…Renal Cell Carcinoma (RCC) is the most common form of kidney cancer, with clear cell RCC (ccRCC) representing about 85% of all RCC tumors. There are limited…”
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Opportunities for the repurposing of PARP inhibitors for the therapy of non‐oncological diseases by Berger, Nathan A, Besson, Valerie C, Boulares, A Hamid, Bürkle, Alexander, Chiarugi, Alberto, Clark, Robert S, Curtin, Nicola J, Cuzzocrea, Salvatore, Dawson, Ted M, Dawson, Valina L, Haskó, György, Liaudet, Lucas, Moroni, Flavio, Pacher, Pál, Radermacher, Peter, Salzman, Andrew L, Snyder, Solomon H, Soriano, Francisco Garcia, Strosznajder, Robert P, Sümegi, Balázs, Swanson, Raymond A, Szabo, Csaba

“…The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for potential therapeutic repurposing for non‐oncological…”
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PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis by Mukhopadhyay, Partha, Horváth, Béla, Rajesh, Mohanraj, Varga, Zoltán V, Gariani, Karim, Ryu, Dongryeol, Cao, Zongxian, Holovac, Eileen, Park, Ogyi, Zhou, Zhou, Xu, Ming-Jiang, Wang, Wei, Godlewski, Grzegorz, Paloczi, Janos, Nemeth, Balazs Tamas, Persidsky, Yuri, Liaudet, Lucas, Haskó, György, Bai, Peter, Boulares, A. Hamid, Auwerx, Johan, Gao, Bin, Pacher, Pal

“…Graphical abstract…”
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Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice by BINDOM, Sharell M, HANS, Chetan P, HUIJING XIA, BOULARES, A. Hamid, LAZARTIGUES, Eric

“…Several clinical studies have shown the benefits of renin-angiotensin system (RAS) blockade in the development of diabetes, and a local RAS has been identified…”
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Poly (ADP‐ribose) polymerase‐1 is a key mediator of liver inflammation and fibrosis by Mukhopadhyay, Partha, Rajesh, Mohanraj, Cao, Zongxian, Horváth, Béla, Park, Ogyi, Wang, Hua, Erdelyi, Katalin, Holovac, Eileen, Wang, Yuping, Liaudet, Lucas, Hamdaoui, Nabila, Lafdil, Fouad, Haskó, György, Szabo, Csaba, Boulares, A. Hamid, Gao, Bin, Pacher, Pal

“…Poly (ADP‐ribose) polymerase 1 (PARP‐1) is a constitutive enzyme, the major isoform of the PARP family, which is involved in the regulation of DNA repair, cell…”
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Immunohistochemistry as an accurate tool for evaluating BRAF-V600E mutation in 130 samples of papillary thyroid cancer by Abd Elmageed, Zakaria Y., PhD, Sholl, Andrew B., MD, Tsumagari, Koji, MD, PhD, Al-Qurayshi, Zaid, MD, Basolo, Fulvio, MD, Moroz, Krzysztof, MD, Boulares, A. Hamid, PhD, Friedlander, Paul, MD, Miccoli, Paulo, MD, Kandil, Emad, MD

“…Background BRAF V600E mutation has been investigated by immunohistochemistry and has shown high sensitivity and specificity. We aim to investigate the accuracy…”
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PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function by Yassin, Lina M., Boulares, Hamid, Yélamos, José, Kim, Hogyoung, Luu, Hanh H., Wyczechowska, Dorota, Al-Khami, Amir A., Wang, Jeffrey, Ghonim, Mohamed A., Echeverri Tirado, Laura C., Sanchez-Pino, Maria Dulfary

“…Dendritic cells (DCs) are critical in asthma and many other immune diseases. We previously demonstrated a role for PARP-1 in asthma. Evidence on PARP-1 playing…”
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Combination of Tipifarnib and Sunitinib Overcomes Renal Cell Carcinoma Resistance to Tyrosine Kinase Inhibitors via Tumor-Derived Exosome and T Cell Modulation by Greenberg, Jacob W, Kim, Hogyoung, Ahn, Miae, Moustafa, Ahmed A, Zhou, He, Barata, Pedro C, Boulares, A Hamid, Abdel-Mageed, Asim B, Krane, Louis S

“…Tyrosine kinase inhibitors (TKI) were initially demonstrated as an efficacious treatment for renal cell carcinoma (RCC). However, after a median treatment…”
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Sulfated non-anticoagulant heparin blocks Th2-induced asthma by modulating the IL-4/signal transducer and activator of transcription 6/Janus kinase 1 pathway by Ghonim, Mohamed A, Wang, Jeffrey, Ibba, Salome V, Luu, Hanh H, Pyakurel, Kusma, Benslimane, Ilyes, Mousa, Shaker, Boulares, A Hamid

“…The efficacy of heparins and low-MW-heparins (LMWH) against human asthma has been known for decades. However, the clinical utility of these compounds has been…”
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Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy by Wang, Jeffrey, Ghonim, Mohamed A, Ibba, Salome V, Luu, Hanh H, Aydin, Yucel, Greer, Peter A, Boulares, A Hamid

“…We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a…”
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PARP‐1 deficiency blocks IL‐5 expression through calpain‐dependent degradation of STAT‐6 in a murine asthma model by Datta, R., Naura, A. S., Zerfaoui, M., Errami, Y., Oumouna, M., Kim, H., Ju, J., Ronchi, V. P., Haas, A. L., Boulares, A. H.

“…To cite this article: Datta R, Naura AS, Zerfaoui M, Errami Y, Oumouna M, Kim H, Ju J, Ronchi VP, Haas AL, Boulares AH. PARP‐1 deficiency blocks IL‐5…”
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Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex by Ghonim, Mohamed A, Ju, Jihang, Pyakurel, Kusma, Ibba, Salome V, Abouzeid, Mai M, Rady, Hamada F, Matsuyama, Shigemi, Del Valle, Luis, Boulares, A Hamid

“…The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in…”
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Simultaneous suppression of the MAP kinase and NF-κB pathways provides a robust therapeutic potential for thyroid cancer by Tsumagari, Koji, Abd Elmageed, Zakaria Y, Sholl, Andrew B, Friedlander, Paul, Abdraboh, Mohamed, Xing, Mingzhao, Boulares, A. Hamid, Kandil, Emad

“…Highlights • We examined simultaneous targeting of two pathways, the MAP kinase and NF-κB pathways. • We used two FDA approved drugs, AZD6244 and Bortezomib. •…”
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Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer by Ghonim, Mohamed A, Ibba, Salome V, Tarhuni, Abdelmetalab F, Errami, Youssef, Luu, Hanh H, Dean, Matthew J, El-Bahrawy, Ali H, Wyczechowska, Dorota, Benslimane, Ilyes A, Del Valle, Luis, Al-Khami, Amir A, Ochoa, Augusto C, Boulares, A Hamid

“…BackgroundPoly(ADP-ribose) polymerase (PARP) inhibitors (eg, olaparib) are effective against BRCA-mutated cancers at/near maximum tolerated doses by trapping…”
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Poly(ADP-ribose) polymerase-1 is a key mediator of cisplatin-induced kidney inflammation and injury by Mukhopadhyay, Partha, Horváth, Béla, Kechrid, Malek, Tanchian, Galin, Rajesh, Mohanraj, Naura, Amarjit S., Boulares, A. Hamid, Pacher, Pál

“…Cisplatin is a commonly used chemotherapeutic drug, the clinical use of which is limited by the development of dose-dependent nephrotoxicity. Enhanced…”
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Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation by Kanai, Masayuki, Miwa, Masanao, Hanashiro, Kazuhiko, Kim, Song-Hee, Hanai, Shuji, Fukasawa, Kenji, Boulares, A. Hamid

“…Poly(ADP-ribose) polymerase 1 (PARP-1) and p53 are two key proteins in the DNA-damage response. Although PARP-1 is known to poly(ADP-ribosyl)ate p53, the role…”
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Differential effects of poly(ADP ribose) polymerase inhibitor-based metronomic therapy on programmed death-ligand 1 and matrix-associated factors in human myeloid cells by Ibba, Salome V, Luu, Hanh H, Boulares, A Hamid

“…We recently showed that while partial poly(ADP-ribose) polymerase (PARP)-1 inhibition with a low metronomic sub-half-maximal inhibitory concentration/dose…”
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Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival by Lassak, Adam, Dean, Mathew, Wyczechowska, Dorota, Wilk, Anna, Marrero, Luis, Trillo-Tinoco, Jimena, Boulares, A. Hamid, Sarkaria, Jann N., Del Valle, Luis, Peruzzi, Francesca, Ochoa, Augusto, Reiss, Krzysztof

“…Insulin receptor substrate 1 (IRS-1) is a common cytosolic adaptor molecule involved in signal transduction from insulin and insulin-like growth factor I…”
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Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db Mice by BELMADANI, Souad, PALEN, Desiree I, GONZALEZ-VILLALOBOS, Romer A, BOULARES, Hamid A, MATROUGUI, Khalid

“…Elevated Epidermal Growth Factor Receptor Phosphorylation Induces Resistance Artery Dysfunction in Diabetic db/db Mice Souad Belmadani 1 , Desiree I. Palen 2 ,…”
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PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice by Ghonim, Mohamed A, Pyakurel, Kusma, Ibba, Salome V, Wang, Jeffrey, Rodriguez, Paulo, Al-Khami, Amir A, Lammi, Matthew R, Kim, Hogyoung, Zea, Arnold H, Davis, Christian, Okpechi, Samuel, Wyczechowska, Dorota, Al-Ghareeb, Kamel, Mansy, Moselhy S, Ochoa, Augusto, Naura, Amarjit S, Boulares, A Hamid

“…Our laboratory established a role for poly(ADP-ribose)polymerase (PARP) in asthma. To increase the clinical significance of our studies, it is imperative to…”
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