Search Results - "Boukhaled, Giselle M."

Opposing Roles of Type I Interferons in Cancer Immunity by Boukhaled, Giselle M, Harding, Shane, Brooks, David G

“…The immune system is tasked with identifying malignant cells to eliminate or prevent cancer spread. This involves a complex orchestration of many immune cell…”
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Chromatin Architecture as an Essential Determinant of Dendritic Cell Function by Boukhaled, Giselle M, Corrado, Mario, Guak, Hannah, Krawczyk, Connie M

“…Epigenetics has widespread implications in a variety of cellular processes ranging from cell identity and specification, to cellular adaptation to…”
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Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control by Guo, Mengdi, Abd-Rabbo, Diala, Bertol, Bruna C., Carew, Madeleine, Lukhele, Sabelo, Snell, Laura M., Xu, Wenxi, Boukhaled, Giselle M., Elsaesser, Heidi, Halaby, Marie Jo, Hirano, Naoto, McGaha, Tracy L., Brooks, David G.

“…CD4 T cells are central effectors of anti-cancer immunity and immunotherapy, yet the regulation of CD4 tumor-specific T (TTS) cells is unclear. We demonstrate…”
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The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence by Boukhaled, Giselle M., Cordeiro, Brendan, Deblois, Genevieve, Dimitrov, Vassil, Bailey, Swneke D., Holowka, Thomas, Domi, Anisa, Guak, Hannah, Chiu, Huai-Hsuan Clare, Everts, Bart, Pearce, Edward J., Lupien, Mathieu, White, John H., Krawczyk, Connie M.

“…Pro-inflammatory signals provided by the microenvironment are critical to activate dendritic cells (DCs), components of the innate immune system that shape…”
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MicroRNA-9 Fine-Tunes Dendritic Cell Function by Suppressing Negative Regulators in a Cell-Type-Specific Manner by Cordeiro, Brendan, Jeon, Peter, Boukhaled, Giselle M., Corrado, Mario, Lapohos, Orsolya, Roy, Dominic G., Williams, Kelsey, Jones, Russell G., Gruenheid, Samantha, Sagan, Selena M., Krawczyk, Connie M.

“…Dendritic cells, cells of the innate immune system, are found in a steady state poised to respond to activating stimuli. Once stimulated, they rapidly undergo…”
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Mass cytometry immunostaining protocol for multiplexing clinical samples by Gadalla, Ramy, Boukhaled, Giselle M., Brooks, David G., Wang, Ben X.

“…This is a cytometry by time-of-flight (CyTOF) staining protocol for hematopoietic-derived cells, that leverages live-cell barcoding using receptor-type…”
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Type I interferon signaling, regulation and gene stimulation in chronic virus infection by Lukhele, Sabelo, Boukhaled, Giselle M., Brooks, David G.

“…Type I Interferons (IFN-I) mediate numerous immune interactions during viral infections, from the establishment of an antiviral state to invoking and…”
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Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity by Smith, Logan K., Boukhaled, Giselle M., Condotta, Stephanie A., Mazouz, Sabrina, Guthmiller, Jenna J., Vijay, Rahul, Butler, Noah S., Bruneau, Julie, Shoukry, Naglaa H., Krawczyk, Connie M., Richer, Martin J.

“…Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the…”
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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells by Loo Yau, Helen, Bell, Emma, Ettayebi, Ilias, de Almeida, Felipe Campos, Boukhaled, Giselle M., Shen, Shu Yi, Allard, David, Morancho, Beatriz, Marhon, Sajid A., Ishak, Charles A., Gonzaga, Isabela M., da Silva Medina, Tiago, Singhania, Rajat, Chakravarthy, Ankur, Chen, Raymond, Mehdipour, Parinaz, Pommey, Sandra, Klein, Christian, Amarante-Mendes, Gustavo P., Roulois, David, Arribas, Joaquín, Stagg, John, Brooks, David G., De Carvalho, Daniel D.

“…We demonstrate that DNA hypomethylating agent (HMA) treatment can directly modulate the anti-tumor response and effector function of CD8+ T cells. In vivo HMA…”
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Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy by Boukhaled, Giselle M., Gadalla, Ramy, Elsaesser, Heidi J., Abd-Rabbo, Diala, Quevedo, Rene, Yang, S. Y. Cindy, Guo, Mengdi, Wang, Ben X., Noamani, Babak, Gray, Diana, Lau, Sally C. M., Taylor, Kirsty, Aung, Kyaw, Spreafico, Anna, Hansen, Aaron R., Saibil, Samuel D., Hirano, Naoto, Guidos, Cynthia, Pugh, Trevor J., McGaha, Tracy L., Ohashi, Pamela S., Sacher, Adrian G., Butler, Marcus O., Brooks, David G.

“…Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition…”
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Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection by Elsaesser, Heidi J., Mohtashami, Mahmood, Osokine, Ivan, Snell, Laura M., Cunningham, Cameron R., Boukhaled, Giselle M., McGavern, Dorian B., Zúñiga-Pflücker, Juan Carlos, Brooks, David G.

“…Chronic infection provokes alterations in inflammatory and suppressive pathways that potentially affect the function and integrity of multiple tissues,…”
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202 Investigating the role of interferon in promoting flares of SLE at a single cell level by Faheem, Zoha, Boukhaled, Giselle M, Manion, Kieran, Munoz-Grajales, Carolina, Nassar, Carol, Kim, Mickael, Gladman, Dafna, Urowitz, Murray, Touma, Zahi, Brooks, David, Wither, Joan

“…BackgroundElevated levels of interferons (IFN) are a hallmark of Systemic Lupus Erythematosus (SLE) and have been linked to disease flares, but the precise…”
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IL-2 produced by HBV-specific T cells as a biomarker of viral control and predictor of response to PD-1 therapy across clinical phases of chronic hepatitis B by Chua, Conan, Salimzadeh, Loghman, Ma, Ann T, Adeyi, Oyedele A, Seo, Hobin, Boukhaled, Giselle M, Mehrotra, Aman, Patel, Anjali, Ferrando-Martinez, Sara, Robbins, Scott H, La, Danie, Wong, David, Janssen, Harry L A, Brooks, David G, Feld, Jordan J, Gehring, Adam J

“…There are no immunological biomarkers that predict control of chronic hepatitis B (CHB). The lack of immune biomarkers raises concerns for therapies targeting…”
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Reactivity to type I interferon is key to predict cancer immunotherapy response

“…The response of circulating effector CD4 T cells to type I interferons (IFN-I) correlates with the overall survival of patients with cancer receiving immune…”
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Peripheral CD4 T cell resistance to type I interferon defines outcome of PD1 blockade therapy in human cancer by Boukhaled, Giselle M, Gadalla, Ramy, Elsaesser, Heidi J., Sacher, Adrian, Butler, Marcus O, Brooks, David G.

“…Abstract Type I interferons (IFN-Is) are paradoxically associated with both the success and failure of immune checkpoint blockade (ICB), with increased…”
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