Search Results - "Bougis, Pierre E"

Serotherapy against Voltage-Gated Sodium Channel-Targeting αToxins from Androctonus Scorpion Venom by Martin-Eauclaire, Marie-France, Adi-Bessalem, Sonia, Hammoudi-Triki, Djelila, Laraba-Djebari, Fatima, Bougis, Pierre E

“…Because of their venom lethality towards mammals scorpions of the genus are considered a critical threat to human health in North Africa. Several decades of…”
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MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity by Rosso, Jean-Pierre, Schwarz, Jürgen R, Diaz-Bustamante, Marcelo, Céard, Brigitte, Gutiérrez, José M, Kneussel, Matthias, Pongs, Olaf, Bosmans, Frank, Bougis, Pierre E

“…GABA A receptors shape synaptic transmission by modulating Cl ⁻ conductance across the cell membrane. Remarkably, animal toxins that specifically target GABA A…”
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Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus by Martin-Eauclaire, Marie-France, Bougis, Pierre E.

“…K+ channels selectively transport K+ ions across cell membranes and play a key role in regulating the physiology of excitable and nonexcitable cells. Their…”
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Structural basis of α-scorpion toxin action on Na v channels by Clairfeuille, Thomas, Cloake, Alexander, Infield, Daniel T, Llongueras, José P, Arthur, Christopher P, Li, Zhong Rong, Jian, Yuwen, Martin-Eauclaire, Marie-France, Bougis, Pierre E, Ciferri, Claudio, Ahern, Christopher A, Bosmans, Frank, Hackos, David H, Rohou, Alexis, Payandeh, Jian

“…Fast inactivation of voltage-gated sodium (Na ) channels is essential for electrical signaling, but its mechanism remains poorly understood. Here we determined…”
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Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography by Bourne, Yves, Grassi, Jacques, Bougis, Pierre E., Marchot, Pascale

“…Acetylcholinesterase, a polymorphic enzyme, appears to form amphiphilic and nonamphiphilic tetramers from a single splice variant; this suggests discrete…”
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Ts1 from the Brazilian scorpion Tityus serrulatus: A half-century of studies on a multifunctional beta like-toxin by Martin-Eauclaire, Marie-France, Bougis, Pierre E., de Lima, Maria Elena

“…The Tityus serrulatus scorpion species represents a serious human health threat to in Brazil because it is among the animals that produces the most dangerous…”
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The scorpion toxin Bot IX is a potent member of the α‐like family and has a unique N‐terminal sequence extension by Martin‐Eauclaire, Marie‐France, Salvatierra, Juan, Mansuelle, Pascal, Bosmans, Frank, Bougis, Pierre E.

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Comparative analyses and implications for antivenom serotherapy of four Moroccan scorpion Buthus occitanus venoms: Subspecies tunetanus, paris, malhommei, and mardochei by Emerich, Bruna Luiza, De Lima, Maria Elena, Martin-Eauclaire, Marie-France, Bougis, Pierre E.

“…Temporary passive immunity such as serotherapy against venoms requires the full knowledge of all venom's components. Here, four venoms from Moroccan common…”
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The scorpion toxin Bot IX is a potent member of the α‐like family and has a unique N‐terminal sequence extension by Martin‐Eauclaire, Marie‐France, Salvatierra, Juan, Bosmans, Frank, Bougis, Pierre E.

“…We report the detailed chemical, immunological and pharmacological characterization of the α‐toxin Bot IX from the Moroccan scorpion Buthus occitanus tunetanus…”
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Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus (Lutz and Mello, 1922) by Martin-Eauclaire, Marie-France, Pimenta, Adriano M.C., Bougis, Pierre E., De Lima, Maria-Elena

“…Potassium (K+) channels are trans-membrane proteins, which play a key role in cellular excitability and signal transduction pathways. Scorpion toxins blocking…”
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A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif by Martin-Eauclaire, Marie-France, Ferracci, Géraldine, Bosmans, Frank, Bougis, Pierre E

“…Animal toxins that inhibit voltage-gated sodium (Na(v)) channel fast inactivation can do so through an interaction with the S3b-S4 helix-turn-helix region, or…”
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Achieving automated scorpion venom mass fingerprinting (VMF) in the nanogram range by Martin-Eauclaire, Marie-France, Granjeaud, Samuel, Belghazi, Maya, Bougis, Pierre E.

“…During the past decade mass spectrometry (MS) has become one of the major suitable techniques for peptide and protein analysis from animal venoms, not only to…”
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Characterization of the first K+ channel blockers from the venom of the Moroccan scorpion Buthus occitanus Paris by Martin-Eauclaire, Marie-France, Céard, Brigitte, Belghazi, Maya, Lebrun, Régine, Bougis, Pierre E.

“…The availability of a large variety of specific blockers, which inhibit different K+ currents, would help to elucidate their differences in physiological…”
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A first exploration of the venom of the Buthus occitanus scorpion found in southern France by Martin-Eauclaire, Marie-France, Bosmans, Frank, Céard, Brigitte, Diochot, Sylvie, Bougis, Pierre E.

“…Even though Buthus occitanus scorpions are found throughout the Mediterranean region, a lack of distinctive characteristics has hampered their classification…”
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A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes by Abbas, Najwa, Belghazi, Maya, Abdel-Mottaleb, Yousra, Tytgat, Jan, Bougis, Pierre E., Martin-Eauclaire, Marie-France

“…In this paper were described the purification, the sequencing, and the immunological and biological characterization of a new Kaliotoxin analog, Aam-KTX, from…”
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Involvement of endogenous opioid system in scorpion toxin-induced antinociception in mice by Martin-Eauclaire, Marie-France, Abbas, Najwa, Sauze, Nicole, Mercier, Laurence, Berge-Lefranc, Jean-Louis, Condo, Jocelyne, Bougis, Pierre E., Guieu, Régis

“…The present study analyzes the involvement of the endogenous opioid system in the antinociceptive effects produced in mammals after α- or β- scorpion toxin…”
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Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly by Bourne, Y, Taylor, P, Bougis, P E, Marchot, P

“…The crystal structure of mouse acetylcholinesterase at 2.9-A resolution reveals a tetrameric assembly of subunits with an antiparallel alignment of two…”
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New analysis of the toxic compounds from the Androctonus mauretanicus mauretanicus scorpion venom by Oukkache, Naoual, Rosso, Jean-Pierre, Alami, Meriem, Ghalim, Norredine, Saïle, Rachid, Hassar, Mohammed, Bougis, Pierre E., Martin-Eauclaire, Marie-France

“…Scorpion venoms are very complex mixtures of molecules, most of which are peptides displaying different kinds of biological activity. Indeed, these peptides…”
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Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom by Marchot, Pascale, Prowse, Claudine N., Kanter, Joan, Camp, Shelley, Ackermann, Elizabeth J., Radić, Zoran, Bougis, Pierre E., Taylor, Palmer

“…Fasciculin, a selective peptidic inhibitor of acetylcholinesterase, is a member of the three-fingered peptide toxin superfamily isolated from snake venoms. The…”
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Kv4 channels sensitive to BmTX3 in rat nervous system: autoradiographic analysis of their distribution during brain ontogenesis by Vacher, Hélène, Diochot, Sylvie, Bougis, Pierre E., Martin-Eauclaire, Marie-France, Mourre, Christiane

“…The binding site distribution of sBmTX3, a chemically synthesized toxin originally purified from the venom of the scorpion Buthus martensi, was investigated in…”
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