Search Results - "Bouffler, S D"

Radiation Cataractogenesis: A Review of Recent Studies by Ainsbury, E. A., Bouffler, S. D., Dörr, W., Graw, J., Muirhead, C. R., Edwards, A. A., Cooper, J.

“…Ainsbury, E. A., Bouffler, S. D., Dörr, W., Graw, J., Muirhead, C. R., Edwards, A. A. and Cooper, J. Radiation Cataractogenesis: A Review of Recent Studies…”
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Frequency of acute myeloid leukaemia-associated mouse chromosome 2 deletions in X-ray exposed immature haematopoietic progenitors and stem cells by Olme, C.-H., Brown, N., Finnon, R., Bouffler, S.D., Badie, C.

“…Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial…”
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Assessing Radiation-Associated Mutational Risk to the Germline: Repetitive DNA Sequences as Mutational Targets and Biomarkers by Bouffler, S. D., Bridges, B. A., Cooper, D. N., Dubrova, Y., McMillan, T. J., Thacker, J., Wright, E. G., Waters, R.

“…Bouffler, S. D., Bridges, B. A., Cooper, D. N., Dubrova, Y., McMillan, T. J., Thacker, J., Wright, E. G. and Waters, R. Assessing Radiation-Associated…”
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The Evidence for Excess Risk of Cancer and Non-Cancer Disease at Low Doses and Dose Rates by Simon, S.L., Kendall, G.M., Bouffler, S.D., Little, M.P.

“…The question of whether there are excess radiation-associated health risks at low dose is controversial. We present evidence of excess cancer risks in a number…”
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Evidence for variation in human radiosensitivity and its potential impact on radiological protection by Bouffler, S.D.

“…Radiological protection standards generally assume that all members of the population are equally sensitive to the adverse health effects associated with…”
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Dose-rate effects in radiation biology and radiation protection by Rühm, W., Azizova, T.V., Bouffler, S.D., Little, M.P., Shore, R.E., Walsh, L., Woloschak, G.E.

“…Quantification of biological effects (cancer, other diseases, and cell damage) associated with exposure to ionising radiation has been a major issue for the…”
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Evidence for Msh2 haploinsufficiency in mice revealed by MNU-induced sister-chromatid exchange analysis by BOUFFLER, S. D, HOFLAND, N, COX, R, FODDE, R

“…The role of Msh2 in chromosome stability has been investigated in a targeted mouse model for HNPCC, Msh2Delta7N. Chromosome aberration frequencies were similar…”
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Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay by Darakhshan, F., Badie, C., Moody, J., Coster, M., Finnon, R., Finnon, P., Edwards, A.A., Szłuińska, M., Skidmore, C.J., Yoshida, K., Ullrich, R., Cox, R., Bouffler, S.D.

“…The mapping of genes which affect individual cancer risk is an important but complex challenge. A surrogate assay of susceptibility to radiation-induced acute…”
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Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice by BOUFFLER, S. D, KEMP, C. J, BALMAIN, A, COX, R

“…Chromosomal abnormalities have been assessed in p53-deficient mice. The in vivo frequency of spontaneous stable aberrations in bone marrow cells was elevated…”
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Upregulation of telomerase activity by X-irradiation in mouse leukaemia cells is independent of Tert, Terc, Tnks and Myc transcription by Finnon, Paul, Silver, Andrew R.J., Bouffler, Simon D.

“…X-irradiation of two mouse myeloid leukaemia cell lines was found to lead to increased telomerase activities. Maximal increases in activity at 24 h…”
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Telomeric sequences, radiation sensitivity and genomic instability by Bouffler, S. D., Blasco, M. A., Cox, R., Smith, P. J.

“…Purpose : To review the basic features of telomeres with particular emphasis on their potential importance in radiation biology. Recent findings suggest that…”
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In utero haemopoietic sensitivity to alpha, beta or X-irradiation in CBA/H mice by Kozlowski, S. D. Bouffler, J. W. Haines, J. D. Harrison, R. Cox, R.

“…Purpose : To assess in utero sensitivity to x-rays, α -emissions from plutonium-239 and β -emissions from tritium in terms of induction of chromosomal…”
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Flt3-ITD mutations in a mouse model of radiation-induced acute myeloid leukaemia by Finnon, R, Brown, N, Moody, J, Badie, C, Olme, C-H, Huiskamp, R, Meijne, E, Sutmuller, M, Rosemann, M, Bouffler, S D

“…Acute myeloid leukaemia (AML) is one of the most common malignancies seen to occur in human populations exposed to ionising radiation. Mouse models have been…”
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Live cell detection of chromosome 2 deletion and Sfpi1/PU1 loss in radiation-induced mouse acute myeloid leukaemia by Olme, C.-H, Finnon, R, Brown, N, Kabacik, S, Bouffler, S.D, Badie, C

“…Abstract The CBA/H mouse model of radiation-induced acute myeloid leukaemia (rAML) has been studied for decades to bring to light the molecular mechanisms…”
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Telomere length, chromatin structure and chromosome fusigenic potential by Slijepcevic, P, Hande, M P, Bouffler, S D, Lansdorp, P, Bryant, P E

“…Telomeres are specialized structures at chromosome ends that are thought to function as buffers against chromosome fusion. Several studies suggest that…”
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Chromosome 2 hypersensitivity and clonal development in murine radiation acute myeloid leukaemia by BOUFFLER, S. D, MEIJNE, E. I. M, MORRIS, D. J, PAPWORTH, D

“…Acute myeloid leukaemias induced by ionizing radiation in mouse are characterized by chromosome (chr) 2 aberrations. While it is known that chr 2 aberrations…”
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Long but dysfunctional telomeres correlate with chromosomal radiosensitivity in a mouse AML cell line by Finnon, P., Wong, Hiu-Pak, Silver, A. R. J., Slijepcevic, P., Bouffler, S. D.

“…Purpose : To compare the chromosomal radiosensitivity of C3H mouse acute myeloid leukaemia (AML) cell lines 7926 and 8709 and to investigate the mechanistic…”
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The lens of the eye: exposures in the UK medical sector and mechanistic studies of radiation effects by Bouffler, S.D., Peters, S., Gilvin, P., Slack, K., Markiewicz, E., Quinlan, R.A., Gillan, J., Coster, M., Barnard, S., Rothkamm, K., Ainsbury, E.

“…The recommendation from the International Commission on Radiological Protection that the occupational equivalent dose limit for the lens of the eye should be…”
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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres by Espejel, Silvia, Franco, Sonia, Rodríguez-Perales, Sandra, Bouffler, Simon D., Cigudosa, Juan C., Blasco, María A.

“…Here we analyze the functional interaction between Ku86 and telomerase at the mammalian telomere by studying mice deficient for both proteins. We show that…”
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Chromosomal mechanisms in murine radiation acute myeloid leukaemogenesis by Bouffler, Simon D., Breckon, George, Cox, Roger

“…Chromosome 2 abnormalities, particularly interstitial deletions, characterize murine radiation-induced acute myeloid leukaemias (AMLs). Here, G-band analyses…”
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