Search Results - "Bouffard, Amanda A."

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide by Jan, Max, Scarfò, Irene, Larson, Rebecca C, Walker, Amanda, Schmidts, Andrea, Guirguis, Andrew A, Gasser, Jessica A, Słabicki, Mikołaj, Bouffard, Amanda A, Castano, Ana P, Kann, Michael C, Cabral, Maria L, Tepper, Alexander, Grinshpun, Daniel E, Sperling, Adam S, Kyung, Taeyoon, Sievers, Quinlan L, Birnbaum, Michael E, Maus, Marcela V, Ebert, Benjamin L

“…Cell-based therapies are emerging as effective agents against cancer and other diseases. As autonomous "living drugs," these therapies lack precise control…”
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CRISPR-Cas9 disruption of PD-1 enhances activity of universal EGFRvIII CAR T cells in a preclinical model of human glioblastoma by Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Darr, Henia, Henderson, Daniel B., Bouffard, Amanda A., Larson, Rebecca C., Scarfò, Irene, Bailey, Stefanie R., Gerhard, Genevieve M., Frigault, Matthew J., Leick, Mark B., Schmidts, Andrea, Sagert, Jason G., Curry, William T., Carter, Bob S., Maus, Marcela V.

“…Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local…”
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Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma by Larson, Rebecca C., Kann, Michael C., Graham, Charlotte, Mount, Christopher W., Castano, Ana P., Lee, Won-Ho, Bouffard, Amanda A., Takei, Hana N., Almazan, Antonio J., Scarfó, Irene, Berger, Trisha R., Schmidts, Andrea, Frigault, Matthew J., Gallagher, Kathleen M. E., Maus, Marcela V.

“…Chimeric Antigen Receptor (CAR) T cells directed to B cell maturation antigen (BCMA) mediate profound responses in patients with multiple myeloma, but most…”
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Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma by Schmidts, Andrea, Ormhøj, Maria, Choi, Bryan D., Taylor, Allison O., Bouffard, Amanda A., Scarfò, Irene, Larson, Rebecca C., Frigault, Matthew J., Gallagher, Kathleen, Castano, Ana P., Riley, Lauren S., Cabral, Maria L., Boroughs, Angela C., Velasco Cárdenas, Rubí M.-H., Schamel, Wolfgang, Zhou, Jing, Mackay, Sean, Tai, Yu-Tzu, Anderson, Kenneth C., Maus, Marcela V.

“…Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with…”
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Stealth transgenes enable CAR-T cells to evade host immune responses by Grauwet, Korneel, Berger, Trisha, Kann, Michael C, Silva, Harrison, Larson, Rebecca, Leick, Mark B, Bailey, Stefanie R, Bouffard, Amanda A, Millar, David, Gallagher, Kathleen, Turtle, Cameron J, Frigault, Matthew J, Maus, Marcela V

“…BackgroundAdoptive cell therapy, such as chimeric antigen receptor (CAR)-T cell therapy, has improved patient outcomes for hematological malignancies…”
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Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources by Schmidts, Andrea, Marsh, Leah C, Srivastava, Ambike A, Bouffard, Amanda A, Boroughs, Angela C, Scarfò, Irene, Larson, Rebecca C, Bedoya, Felipe, Choi, Bryan D, Frigault, Matthew J, Bailey, Stefanie R, Leick, Mark B, Vatsa, Sonika, Kann, Michael C, Prew, Michelle S, Kleinstiver, Benjamin P, Joung, J Keith, Maus, Marcela V

“…BackgroundAdoptive cell therapy with chimeric antigen receptor T cells (CAR-T) has become a standard treatment for patients with certain aggressive B cell…”
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CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours by Larson, Rebecca C., Kann, Michael C., Bailey, Stefanie R., Haradhvala, Nicholas J., Llopis, Paula Montero, Bouffard, Amanda A., Scarfó, Irene, Leick, Mark B., Grauwet, Korneel, Berger, Trisha R., Stewart, Kai, Anekal, Praju Vikas, Jan, Max, Joung, Julia, Schmidts, Andrea, Ouspenskaia, Tamara, Law, Travis, Regev, Aviv, Getz, Gad, Maus, Marcela V.

“…Chimeric antigen receptor (CAR) therapy has had a transformative effect on the treatment of haematologic malignancies 1 – 6 , but it has shown limited efficacy…”
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CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity by Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Bouffard, Amanda A., Schmidts, Andrea, Larson, Rebecca C., Bailey, Stefanie R., Boroughs, Angela C., Frigault, Matthew J., Leick, Mark B., Scarfò, Irene, Cetrulo, Curtis L., Demehri, Shadmehr, Nahed, Brian V., Cahill, Daniel P., Wakimoto, Hiroaki, Curry, William T., Carter, Bob S., Maus, Marcela V.

“…Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to heterogeneous target antigen expression and outgrowth of tumors lacking the…”
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Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia by Leick, Mark B., Silva, Harrison, Scarfò, Irene, Larson, Rebecca, Choi, Bryan D., Bouffard, Amanda A., Gallagher, Kathleen, Schmidts, Andrea, Bailey, Stefanie R., Kann, Michael C., Jan, Max, Wehrli, Marc, Grauwet, Korneel, Horick, Nora, Frigault, Matthew J., Maus, Marcela V.

“…Chimeric antigen receptor (CAR) T cell therapy is effective in lymphoid malignancies, but there has been limited data in myeloid cancers. Here, we start with a…”
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Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas by Scarfò, Irene, Ormhøj, Maria, Frigault, Matthew J., Castano, Ana P., Lorrey, Selena, Bouffard, Amanda A., van Scoyk, Alexandria, Rodig, Scott J., Shay, Alexandra J., Aster, Jon C., Preffer, Frederic I., Weinstock, David M., Maus, Marcela V.

“…Chimeric antigen receptor (CAR) T cells have emerged as a novel form of treatment of patients with B-cell malignancies. In particular, anti-CD19 CAR T-cell…”
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Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 by Ormhøj, Maria, Scarfò, Irene, Cabral, Maria L, Bailey, Stefanie R, Lorrey, Selena J, Bouffard, Amanda A, Castano, Ana P, Larson, Rebecca C, Riley, Lauren S, Schmidts, Andrea, Choi, Bryan D, Andersen, Rikke S, Cédile, Oriane, Nyvold, Charlotte G, Christensen, Jacob H, Gjerstorff, Morten F, Ditzel, Henrik J, Weinstock, David M, Barington, Torben, Frigault, Matthew J, Maus, Marcela V

“…T cells engineered to express a chimeric antigen receptor (CAR) against CD19 have recently been FDA approved for the treatment of relapsed or refractory large…”
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Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7 by Kann, Michael C., Schneider, Emily M., Almazan, Antonio J., Lane, Isabel C., Bouffard, Amanda A., Supper, Valentina M., Takei, Hana N., Tepper, Alexander, Leick, Mark B., Larson, Rebecca C., Ebert, Benjamin L., Maus, Marcela V., Jan, Max

“…CAR-T cell therapy has emerged as a breakthrough therapy for the treatment of relapsed and refractory hematologic malignancies. However, insufficient CAR-T…”
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Blockade or Deletion of IFNγ Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies by Bailey, Stefanie R, Vatsa, Sonika, Larson, Rebecca C, Bouffard, Amanda A, Scarfò, Irene, Kann, Michael C, Berger, Trisha R, Leick, Mark B, Wehrli, Marc, Schmidts, Andrea, Silva, Harrison, Lindell, Kevin A, Demato, Ashley, Gallagher, Kathleen M E, Frigault, Matthew J, Maus, Marcela V

“…Chimeric antigen receptor (CAR) T cells induce impressive responses in patients with hematologic malignancies but can also trigger cytokine release syndrome…”
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Chimeric antigen receptor costimulation domains modulate human regulatory T cell function by Boroughs, Angela C, Larson, Rebecca C, Choi, Bryan D, Bouffard, Amanda A, Riley, Lauren S, Schiferle, Erik, Kulkarni, Anupriya S, Cetrulo, Curtis L, Ting, David, Blazar, Bruce R, Demehri, Shadmehr, Maus, Marcela V

“…Regulatory T cells (Tregs) are key modulators of inflammation and are important for the maintenance of peripheral tolerance. Adoptive immunotherapy with…”
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Correction: Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19 by Ormhøj, Maria, Scarfò, Irene, Cabral, Maria L, Bailey, Stefanie R, Lorrey, Selena J, Bouffard, Amanda A, Castano, Ana P, Larson, Rebecca C, Riley, Lauren S, Schmidts, Andrea, Choi, Bryan D, Andersen, Rikke S, Cédile, Oriane, Nyvold, Charlotte G, Christensen, Jacob H, Gjerstorff, Morten F, Ditzel, Henrik J, Weinstock, David M, Barington, Torben, Frigault, Matthew J, Maus, Marcela V

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Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma by Wehrli, Marc, Guinn, Samantha, Birocchi, Filippo, Kuo, Adam, Sun, Yi, Larson, Rebecca C, Almazan, Antonio J, Scarfò, Irene, Bouffard, Amanda A, Bailey, Stefanie R, Anekal, Praju Vikas, Montero Llopis, Paula, Nieman, Linda T, Song, Yuhui, Xu, Katherine H, Berger, Trisha R, Kann, Michael C, Leick, Mark B, Silva, Harrison, Salas-Benito, Diego, Kienka, Tamina, Grauwet, Korneel, Armstrong, Todd D, Zhang, Rui, Zhu, Qingfeng, Fu, Juan, Schmidts, Andrea, Korell, Felix, Jan, Max, Choi, Bryan D, Liss, Andrew S, Boland, Genevieve M, Ting, David T, Burkhart, Richard A, Jenkins, Russell W, Zheng, Lei, Jaffee, Elizabeth M, Zimmerman, Jacquelyn W, Maus, Marcela V

“…Targeting solid tumors with chimeric antigen receptor (CAR) T cells remains challenging due to heterogenous target antigen expression, antigen escape, and the…”
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Tandem chimeric antigen receptor (CAR) T cells targeting EGFRvIII and IL-13Rα2 are effective against heterogeneous glioblastoma by Schmidts, Andrea, Srivastava, Ambike A, Ramapriyan, Rishab, Bailey, Stefanie R, Bouffard, Amanda A, Cahill, Daniel P, Carter, Bob S, Curry, William T, Dunn, Gavin P, Frigault, Matthew J, Gerstner, Elizabeth R, Ghannam, Jack Y, Kann, Michael C, Larson, Rebecca C, Leick, Mark B, Nahed, Brian V, Richardson, Leland G, Scarfò, Irene, Sun, Jing, Wakimoto, Hiroaki, Maus, Marcela V, Choi, Bryan D

“…Abstract Background Chimeric antigen receptor (CAR) T cells have achieved remarkable responses in patients with hematological malignancies; however, the…”
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A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy by Lin, William, Sarkar, Ditsa, Kim, Joanna Y, Knudsen, Nelson H, Lane, Isabel C, Cheng, Andi, Kembaun, Gabriele, Kienka, Tamina, Carreiro, Jeannie, Bouffard, Amanda A, Maus, Marcela V, Manguso, Robert T, Jan, Max

“…Cellular immunotherapies, including chimeric antigen receptor (CAR) T cells, have demonstrated promising efficacy against hematologic malignancies and liquid…”
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Blocking IFNγ in CAR-T Reduces Checkpoint Inhibitors and Cell-Mediated Toxicity without Compromising Therapeutic Efficacy in CD19 +malignancies by Bailey, Stefanie R., Vatsa, Sonika, Larson, Rebecca, Bouffard, Amanda A, Scarfò, Irene, Gallagher, Kathleen M.E., Frigault, Matthew J., Maus, Marcela V.

“…Background: Chimeric antigen receptor T cells (CAR-T) induce impressive responses in patients with hematologic malignancies but can also mediate a systemic…”
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Abstract LB-066: BiTE-armored CARs overcome antigen escape in EGFRvIII-targeted therapy for glioblastoma by Choi, Bryan D., Yu, Xiaoling, Castano, Ana P., Bouffard, Amanda A., Curry, William T., Carter, Bob S., Maus, Marcela V.

“…Abstract Glioblastoma (GBM) is a devastating disease with an extremely poor prognosis. Immune therapy with T cells engineered to express chimeric antigen…”
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