Search Results - "Boudreau, Dominic"
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Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain
Published in Nature communications (13-02-2020)“…Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported,…”
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BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
Published in Nature (15-12-2005)“…Neuropathic pain that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord. Spinal microglia…”
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Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
Published in Nature (21-08-2003)“…Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain…”
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Differential Maturation of GABA Action and Anion Reversal Potential in Spinal Lamina I Neurons: Impact of Chloride Extrusion Capacity
Published in The Journal of neuroscience (19-10-2005)“…A deficit in inhibition in the spinal dorsal horn has been proposed to be an underlying cause of the exaggerated cutaneous sensory reflexes observed in newborn…”
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Chloride extrusion enhancers as novel therapeutics for neurological diseases
Published in Nature medicine (01-11-2013)“…Dysfunction of the potassium-chloride cotransporter KCC2 has been linked to many neurological diseases, including pain, anxiety and epilepsy. Now, Yves De…”
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Rapid Mechanically Controlled Rewiring of Neuronal Circuits
Published in The Journal of neuroscience (20-01-2016)“…CNS injury may lead to permanent functional deficits because it is still not possible to regenerate axons over long distances and accurately reconnect them…”
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7
Enhancing neuronal chloride extrusion rescues α2/α3 GABA A -mediated analgesia in neuropathic pain
Published in Nature communications (13-02-2020)“…Spinal disinhibition has been hypothesized to underlie pain hypersensitivity in neuropathic pain. Apparently contradictory mechanisms have been reported,…”
Get full text
Journal Article