ALK protein expression in pulmonary adenocarcinoma of Tunisian patients

ALK protein expression in pulmonary adenocarcinoma of Tunisian patients

Background. It is now necessary to determine ALK status in order to use targeted therapy. Aim: herein, we assess immunohistochemical profile of ALK protein in a series of Tunisian patients with pulmonary adenocarcinoma. Materials and Methods. ALK protein expression was studied applying the D5F3 anti...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry Vol. 38; no. 4; pp. 411 - 419
Main Authors: Arfaoui, Amira Toumi, Blel, Ahlem, Aloui, Raoudha, Fatnassi, Ghaya, Ammar, Jihane Ben, Znaidi, Nadia, Zidi, Yosra, Boudaya, Mohammed Sadok, Aouina, Hichem, Rammeh Rommani, Soumaya
Format: Journal Article
Language:English
Published: England Taylor & Francis 04-07-2017
Marcel Dekker, Inc
Subjects:
Adenocarcinoma
Adenocarcinoma - diagnosis
Adenocarcinoma - metabolism
Adenocarcinoma of Lung
Adult
Aged
Aged, 80 and over
ALK expression
ALK protein
ALK rearrangements
Anaplastic Lymphoma Kinase
D5F3 antibody
Female
Humans
Immunohistochemistry
Lung Neoplasms - diagnosis
Lung Neoplasms - metabolism
Male
Middle Aged
Patients
Protein expression
Proteins
pulmonary adenocarcinoma
Receptor Protein-Tyrosine Kinases - analysis
Receptor Protein-Tyrosine Kinases - biosynthesis
Staining
Tunisia
Tunisia
ALK rearrangements
D5F3 antibody
ALK expression
immunohistochemistry
pulmonary adenocarcinoma
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Summary:Background. It is now necessary to determine ALK status in order to use targeted therapy. Aim: herein, we assess immunohistochemical profile of ALK protein in a series of Tunisian patients with pulmonary adenocarcinoma. Materials and Methods. ALK protein expression was studied applying the D5F3 antibody with a fully automated Ventana CDx technique on a series of 19 patients. Results. Positive ALK expression was found in one case (5.2%) corresponding to a papillary adenocarcinoma which showed a strong granular and homogenous cytoplasmic staining. The patient was a 30-years-old woman. Conclusion. The frequency of positive ALK expression based on immunohistochemistry in our series was similar to that reported in the world literature.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2017.1319860