Search Results - "Boucher, Kenneth M."

Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework by Tavtigian, Sean V, Greenblatt, Marc S, Harrison, Steven M, Nussbaum, Robert L, Prabhu, Snehit A, Boucher, Kenneth M, Biesecker, Leslie G

“…Purpose We evaluated the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) variant pathogenicity guidelines for…”
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Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression by Fukuda, Akihisa, Wang, Sam C., Morris, John P., Folias, Alexandra E., Liou, Angela, Kim, Grace E., Akira, Shizuo, Boucher, Kenneth M., Firpo, Matthew A., Mulvihill, Sean J., Hebrok, Matthias

“…Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and…”
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Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA by Agarwal, Neeraj, Pal, Sumanta K., Hahn, Andrew W., Nussenzveig, Roberto H., Pond, Gregory R., Gupta, Sumati V., Wang, Jue, Bilen, Mehmet A., Naik, Gurudatta, Ghatalia, Pooja, Hoimes, Christopher J., Gopalakrishnan, Dharmesh, Barata, Pedro C., Drakaki, Alexandra, Faltas, Bishoy M., Kiedrowski, Lesli A., Lanman, Richard B., Nagy, Rebecca J., Vogelzang, Nicholas J., Boucher, Kenneth M., Vaishampayan, Ulka N., Sonpavde, Guru, Grivas, Petros

“…BACKGROUND Biomarker‐guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue…”
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Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks by Nix, David A, Courdy, Samir J, Boucher, Kenneth M

“…High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone…”
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The association between socioeconomic factors and breast cancer-specific survival varies by race by Agarwal, Shailesh, Ying, Jian, Boucher, Kenneth M, Agarwal, Jayant P

“…Although racial disparity is well described for oncologic outcomes, factors associated with survival within racial groups remains unexplored. The objective of…”
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A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker by Kelley, Kristen C, Grossman, Kenneth F, Brittain-Blankenship, Mary, Thorne, Kelli M, Akerley, Wallace L, Terrazas, Moises C, Kosak, Ken M, Boucher, Kenneth M, Buys, Saundra S, McGregor, Kimberly A, Werner, Theresa L, Agarwal, Neeraj, Weis, John R, Sharma, Sunil, Ward, John H, Kennedy, Thomas P, Sborov, Douglas W, Shami, Paul J

“…Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of…”
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Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy by Wee, Yinshen, Wang, Junhua, Wilson, Emily C., Rich, Coulson P., Rogers, Aaron, Tong, Zongzhong, DeGroot, Evelyn, Gopal, Y. N. Vashisht, Davies, Michael A., Ekiz, H. Atakan, Tay, Joshua K. H., Stubben, Chris, Boucher, Kenneth M., Oviedo, Juan M., Fairfax, Keke C., Williams, Matthew A., Holmen, Sheri L., Wolff, Roger K., Grossmann, Allie H.

“…Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While…”
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Reduction in nevus biopsies in patients monitored by total body photography by Truong, Amanda, BS, Strazzulla, Lauren, BA, March, Jordon, BS, Boucher, Kenneth M., PhD, Nelson, Kelly C., MD, Kim, Caroline C., MD, Grossman, Douglas, MD, PhD

“…Background Total body photography (TBP) can facilitate identification of new and changing lesions. By confirming that particular nevi are stable, TBP may…”
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Improved melanoma outcomes and survival in patients monitored by total body photography: A natural experiment by Strunck, Jennifer L., Smart, Tristan C., Boucher, Kenneth M., Secrest, Aaron M., Grossman, Douglas

“…Total body photography (TBP) facilitates early melanoma detection, but long‐term outcomes have not been well studied. Our objectives were to examine melanoma…”
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Microsatellites as EWS/FLI response elements in Ewing's sarcoma by Gangwal, Kunal, Sankar, Savita, Hollenhorst, Peter C, Kinsey, Michelle, Haroldsen, Stephen C, Shah, Atul A, Boucher, Kenneth M, Watkins, W. Scott, Jorde, Lynn B, Graves, Barbara J, Lessnick, Stephen L

“…The ETS gene family is frequently involved in chromosome translocations that cause human cancer, including prostate cancer, leukemia, and sarcoma. However, the…”
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First-in-human Mutation-targeted siRNA Phase Ib Trial of an Inherited Skin Disorder by Leachman, Sancy A, Hickerson, Robyn P, Schwartz, Mary E, Bullough, Emily E, Hutcherson, Stephen L, Boucher, Kenneth M, Hansen, C David, Eliason, Mark J, Srivatsa, G Susan, Kornbrust, Douglas J, Smith, Frances JD, McLean, WH Irwin, Milstone, Leonard M, Kaspar, Roger L

“…The rare skin disorder pachyonychia congenita (PC) is an autosomal dominant syndrome that includes a disabling plantar keratoderma for which no satisfactory…”
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Telehealth Personalized Cancer Risk Communication to Motivate Colonoscopy in Relatives of Patients With Colorectal Cancer: The Family CARE Randomized Controlled Trial by KINNEY, Anita Y, BOONYASIRIWAT, Watcharaporn, VERNON, Sally W, SIMMONS, Rebecca G, LOWERY, Jan T, FLORES, Kristina, WIGGINS, Charles L, HILL, Deirdre A, BURT, Randall W, WILLIAMS, Marc S, HIGGINBOTHAM, John C, WALTERS, Scott T, PAPPAS, Lisa M, STROUP, Antoinette M, SCHWARTZ, Marc D, EDWARDS, Sandra L, ROGERS, Amy, KOHLMANN, Wendy K, BOUCHER, Kenneth M

“…The rate of adherence to regular colonoscopy screening in individuals at increased familial risk of colorectal cancer (CRC) is suboptimal, especially among…”
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Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype by Kanth, Priyanka, Bronner, Mary P, Boucher, Kenneth M, Burt, Randall W, Neklason, Deborah W, Hagedorn, Curt H, Delker, Don A

“…Sessile serrated colon adenoma/polyps (SSA/P) are found during routine screening colonoscopy and may account for 20% to 30% of colon cancers. However,…”
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A Comparison of Colon and Rectal Somatic DNA Alterations by Slattery, Martha L, Curtin, Karen, Wolff, Roger K, Boucher, Kenneth M, Sweeney, Carol, Edwards, Sandra, Caan, Bette J, Samowitz, Wade

“…PURPOSE:Differences in acquired mutations in colon and rectal tumors may account for differences in risk factors. In this study, we examined similarities and…”
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Improving Bone Health in Patients with Metastatic Prostate Cancer with the Use of Algorithm-Based Clinical Practice Tool by Sahu, Kamal Kant, Johnson, Eric D, Butler, Katerina, Li, Haoran, Boucher, Kenneth M, Gupta, Sumati

“…Background: The bone health of patients with locally advanced and metastatic prostate cancer is at risk from treatment-related bone density loss and…”
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Label-Free Classification of Apoptosis, Ferroptosis and Necroptosis Using Digital Holographic Cytometry by Barker, Kendra L, Boucher, Kenneth M, Judson-Torres, Robert L

“…Apoptosis, ferroptosis and necroptosis are three distinct forms of programmed cell death. Each of these pathways can be exploited to terminate cancer cells…”
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Implications of inaccurate clinical nodal staging in pancreatic adenocarcinoma by Swords, Douglas S., MD, Firpo, Matthew A., PhD, Johnson, Kirsten M., BS, Boucher, Kenneth M., PhD, Scaife, Courtney L., MD, Mulvihill, Sean J., MD

“…Background Many patients with stage I-II pancreatic adenocarcinoma do not undergo resection. We hypothesized that (1) clinical staging underestimates nodal…”
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MicroRNA Signatures Associated with Basal Cell Carcinoma Subtypes by Fastner, Suzanne, Rahman, Hafeez, Gutierrez, Jose, Shen, Nathan, Florell, Scott R., Florell, Abigail, Stubben, Chris J., Boucher, Kenneth M., Deacon, Dekker C., Judson-Torres, Robert L., Grossman, Douglas

“…Basal cell carcinoma (BCC) is classified histologically into subtypes that determine treatment decisions. MicroRNAs (miRs) are short noncoding RNAs that may…”
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Isolation of circulating microRNAs from microvesicles found in human plasma by Quackenbush, John F, Cassidy, Pamela B, Pfeffer, Lawrence M, Boucher, Kenneth M, Hawkes, Jason E, Pfeffer, Susan R, Kopelovich, Levy, Leachman, Sancy A

“…Intact miRNAs can be isolated from the circulation in significant quantities despite the presence of extremely high levels of RNase activity. The remarkable…”
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Electrical Impedance Dermography Differentiates Squamous Cell Carcinoma In Situ from Inflamed Seborrheic Keratoses by Wen-Ying Wong, Elaine, Pandeya, Sarbesh, Crandall, Henry, Smart, Tristan, Dixon, Madisen, Boucher, Kenneth M., Florell, Scott R., Grossman, Douglas, Sanchez, Benjamin

“…There are no currently available low-cost, noninvasive methods for discerning the depth of squamous cell carcinoma (SCC) invasion or distinguishing SCC from…”
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