Search Results - "Boucher, Kenneth"

Modeling the ACMG/AMP variant classification guidelines as a Bayesian classification framework by Tavtigian, Sean V, Greenblatt, Marc S, Harrison, Steven M, Nussbaum, Robert L, Prabhu, Snehit A, Boucher, Kenneth M, Biesecker, Leslie G

“…Purpose We evaluated the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) variant pathogenicity guidelines for…”
Get full text

Fitting a naturally scaled point system to the ACMG/AMP variant classification guidelines by Tavtigian, Sean V., Harrison, Steven M., Boucher, Kenneth M., Biesecker, Leslie G.

“…Recently, we demonstrated that the qualitative American College of Medical Genetics and Genomics/Association for Medical Pathology (ACMG/AMP) guidelines for…”
Get full text

Stat3 and MMP7 Contribute to Pancreatic Ductal Adenocarcinoma Initiation and Progression by Fukuda, Akihisa, Wang, Sam C., Morris, John P., Folias, Alexandra E., Liou, Angela, Kim, Grace E., Akira, Shizuo, Boucher, Kenneth M., Firpo, Matthew A., Mulvihill, Sean J., Hebrok, Matthias

“…Chronic pancreatitis is a well-known risk factor for pancreatic ductal adenocarcinoma (PDA) development in humans, and inflammation promotes PDA initiation and…”
Get full text

Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks by Nix, David A, Courdy, Samir J, Boucher, Kenneth M

“…High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone…”
Get full text

The association between socioeconomic factors and breast cancer-specific survival varies by race by Agarwal, Shailesh, Ying, Jian, Boucher, Kenneth M, Agarwal, Jayant P

“…Although racial disparity is well described for oncologic outcomes, factors associated with survival within racial groups remains unexplored. The objective of…”
Get full text

Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA by Agarwal, Neeraj, Pal, Sumanta K., Hahn, Andrew W., Nussenzveig, Roberto H., Pond, Gregory R., Gupta, Sumati V., Wang, Jue, Bilen, Mehmet A., Naik, Gurudatta, Ghatalia, Pooja, Hoimes, Christopher J., Gopalakrishnan, Dharmesh, Barata, Pedro C., Drakaki, Alexandra, Faltas, Bishoy M., Kiedrowski, Lesli A., Lanman, Richard B., Nagy, Rebecca J., Vogelzang, Nicholas J., Boucher, Kenneth M., Vaishampayan, Ulka N., Sonpavde, Guru, Grivas, Petros

“…BACKGROUND Biomarker‐guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue…”
Get full text

Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo by Rahman, Hafeez, Kumar, Dileep, Liu, Tong, Okwundu, Nwanneka, Lum, David, Florell, Scott R., Burd, Christin E., Boucher, Kenneth M., VanBrocklin, Matthew W., Grossman, Douglas

“…UVR promotes skin cancer through multiple mechanisms, including induction of inflammation, oxidative stress, and DNA damage such as 8-oxoguanine and…”
Get full text

Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial by Samadder, N. Jewel, Neklason, Deborah W, Boucher, Kenneth M, Byrne, Kathryn R, Kanth, Priyanka, Samowitz, Wade, Jones, David, Tavtigian, Sean V, Done, Michelle W, Berry, Therese, Jasperson, Kory, Pappas, Lisa, Smith, Laurel, Sample, Danielle, Davis, Rian, Topham, Matthew K, Lynch, Patrick, Strait, Elena, McKinnon, Wendy, Burt, Randall W, Kuwada, Scott K

“…IMPORTANCE: Patients with familial adenomatous polyposis (FAP) are at markedly increased risk for duodenal polyps and cancer. Surgical and endoscopic…”
Get full text

Reduction in nevus biopsies in patients monitored by total body photography by Truong, Amanda, BS, Strazzulla, Lauren, BA, March, Jordon, BS, Boucher, Kenneth M., PhD, Nelson, Kelly C., MD, Kim, Caroline C., MD, Grossman, Douglas, MD, PhD

“…Background Total body photography (TBP) can facilitate identification of new and changing lesions. By confirming that particular nevi are stable, TBP may…”
Get full text

Phase I Trial of Combination Therapy With Avelumab and Cabozantinib in Patients With Newly Diagnosed Metastatic Clear Cell Renal Cell Carcinoma by Li, Haoran, Sahu, Kamal Kant, Brundage, James, Benson, Mallory, Swami, Umang, Boucher, Kenneth M, Gupta, Sumati, Hawks, Josiah, Sirohi, Deepika, Agarwal, Neeraj, Maughan, Benjamin L

“…Abstract Background Combination immunotherapy is now considered the standard first-line therapy for patients with metastatic clear cell renal cell carcinoma…”
Get full text

PAM50 breast cancer subtyping by RT-qPCR and concordance with standard clinical molecular markers by Bastien, Roy R L, Rodríguez-Lescure, Álvaro, Ebbert, Mark T W, Prat, Aleix, Munárriz, Blanca, Rowe, Leslie, Miller, Patricia, Ruiz-Borrego, Manuel, Anderson, Daniel, Lyons, Bradley, Álvarez, Isabel, Dowell, Tracy, Wall, David, Seguí, Miguel Ángel, Barley, Lee, Boucher, Kenneth M, Alba, Emilio, Pappas, Lisa, Davis, Carole A, Aranda, Ignacio, Fauron, Christiane, Stijleman, Inge J, Palacios, José, Antón, Antonio, Carrasco, Eva, Caballero, Rosalía, Ellis, Matthew J, Nielsen, Torsten O, Perou, Charles M, Astill, Mark, Bernard, Philip S, Martín, Miguel

“…Many methodologies have been used in research to identify the "intrinsic" subtypes of breast cancer commonly known as Luminal A, Luminal B, HER2-Enriched…”
Get full text

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker by Kelley, Kristen C, Grossman, Kenneth F, Brittain-Blankenship, Mary, Thorne, Kelli M, Akerley, Wallace L, Terrazas, Moises C, Kosak, Ken M, Boucher, Kenneth M, Buys, Saundra S, McGregor, Kimberly A, Werner, Theresa L, Agarwal, Neeraj, Weis, John R, Sharma, Sunil, Ward, John H, Kennedy, Thomas P, Sborov, Douglas W, Shami, Paul J

“…Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of…”
Get full text

Improved melanoma outcomes and survival in patients monitored by total body photography: A natural experiment by Strunck, Jennifer L., Smart, Tristan C., Boucher, Kenneth M., Secrest, Aaron M., Grossman, Douglas

“…Total body photography (TBP) facilitates early melanoma detection, but long‐term outcomes have not been well studied. Our objectives were to examine melanoma…”
Get full text

A Randomized Double-blind Placebo-controlled Trial of Oral Aspirin for Protection of Melanocytic Nevi Against UV-induced DNA Damage by Okwundu, Nwanneka, Rahman, Hafeez, Liu, Tong, Florell, Scott R, Boucher, Kenneth M, Grossman, Douglas

“…DNA damage plays a role in ultraviolet (UV)-induced melanoma. We previously showed that aspirin (ASA) can suppress prostaglandin-E (PGE ) and protect…”
Get full text

Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer by Cowman, Sophie J, Fuja, Daniel G, Liu, Xian-De, Tidwell, Rebecca S Slack, Kandula, Neelima, Sirohi, Deepika, Agarwal, Archana M, Emerson, Lyska L, Tripp, Sheryl R, Mohlman, Jeffrey S, Stonhill, Miekan, Garcia, Guillermina, Conley, Christopher J, Olalde, Adam A, Sargis, Timothy, Ramirez-Torres, Adela, Karam, Jose A, Wood, Christopher G, Sircar, Kanishka, Tamboli, Pheroze, Boucher, Kenneth, Maughan, Benjamin, Spike, Benjamin T, Ho, Thai H, Agarwal, Neeraj, Jonasch, Eric, Koh, Mei Yee

“…Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel-Lindau tumor suppressor, resulting in activation of HIF-1α…”
Get full text

A Multigene Assay Determines Risk of Recurrence in Patients with Triple-Negative Breast Cancer by Stewart, Rachel L, Updike, Katherine L, Factor, Rachel E, Henry, N Lynn, Boucher, Kenneth M, Bernard, Philip S, Varley, Katherine E

“…Approximately 40% of patients with stage I-III triple-negative breast cancer (TNBC) recur after standard treatment, whereas the remaining 60% experience…”
Get full text

Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy by Wee, Yinshen, Wang, Junhua, Wilson, Emily C., Rich, Coulson P., Rogers, Aaron, Tong, Zongzhong, DeGroot, Evelyn, Gopal, Y. N. Vashisht, Davies, Michael A., Ekiz, H. Atakan, Tay, Joshua K. H., Stubben, Chris, Boucher, Kenneth M., Oviedo, Juan M., Fairfax, Keke C., Williams, Matthew A., Holmen, Sheri L., Wolff, Roger K., Grossmann, Allie H.

“…Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While…”
Get full text

Interventions for increasing colorectal cancer screening uptake among African-American men: A systematic review and meta-analysis by Rogers, Charles R, Matthews, Phung, Xu, Lei, Boucher, Kenneth, Riley, Colin, Huntington, Matthew, Le Duc, Nathan, Okuyemi, Kola S, Foster, Margaret J

“…African-American men have the lowest 5-year survival rate in the U.S. for colorectal cancer (CRC) of any racial group, which may partly stem from low screening…”
Get full text

The BREASTrial: Stage I. Outcomes from the Time of Tissue Expander and Acellular Dermal Matrix Placement to Definitive Reconstruction by Mendenhall, Shaun D., Anderson, Layla A., Ying, Jian, Boucher, Kenneth M., Liu, Ting, Neumayer, Leigh A., Agarwal, Jayant P.

“…Use of acellular dermal matrix in tissue expander breast reconstruction has become a popular adjunct to the total submuscular technique. The question remains…”
Get full text

Prospective Pilot Study of 18F-Fluoroestradiol PET/CT in Patients With Invasive Lobular Carcinomas by Covington, Matthew F, Hoffman, John M, Morton, Kathryn A, Buckway, Brandon, Boucher, Kenneth M, Rosenthal, Regina E, Porretta, Jane M, Brownson, Kirstyn E, Matsen, Cindy B, Vaklavas, Christos, Ward, John H, Wei, Mei, Buys, Saundra S, Chittoria, Namita, Yakish, Ellen D, Archibald, Zane G, Burrell, Lance D, Butterfield, Regan I, Yap, Jeffrey T

“…BACKGROUND. PET/CT with 18F-fluoroestradiol (FES) (FDA-approved in 2020) depicts tissues expressing estrogen receptor (ER). Invasive lobular carcinoma (ILC) is…”
Get full text