Search Results - "Bouchard, Géraldine"

Liposome/water lipophilicity: Methods, information content, and pharmaceutical applications by van Balen, Georgette Plemper, Martinet, Catherine a Marca, Caron, Giulia, Bouchard, Géraldine, Reist, Marianne, Carrupt, Pierre-Alain, Fruttero, Roberta, Gasco, Alberto, Testa, Bernard

“…This review discusses liposome/water lipophilicity in terms of the structure of liposomes, experimental methods, and information content. In a first part, the…”
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A Comparison of the Solvation Properties of 2-Nitrophenyloctyl Ether, Nitrobenzene, and n-Octanol as Assessed by Ion Transfer Experiments by Gulaboski, Rubin, Galland, Alexandra, Bouchard, Géraldine, Caban, Karolina, Kretschmer, Ansgar, Carrupt, Pierre-Alain, Stojek, Zbigniew, Girault, Hubert H, Scholz, Fritz

“…The lipophilicity of the anionic forms of drugs and model compounds was assessed by their transfer across (i) the water−2-nitrophenyloctyl ether (NPOE), (ii)…”
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Lipophilicity and Solvation of Anionic Drugs by Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Gobry, Véronique, Girault, Hubert H.

“…This paper first gives a brief review of the main techniques used to measure the lipophilicity of neutral and ionic drugs, namely the shake‐flask method,…”
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Water-oil partition profiling of ionized drug molecules using cyclic voltammetry and a 96-well microfilter plate system by ULMEANU, Sorina M, JENSEN, Henrik, BOUCHARD, Géraldine, CARRUPT, Pierre-Alain, GIRAULT, Hubert H

“…A new experimental set-up for studying partitioning of ionizable drugs at the interface between two immiscible electrolyte solutions (ITIES) by amperometry is…”
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Fluoride curcumin derivatives: new mitochondrial uncoupling agents by Ligeret, Heidi, Barthélémy, Sophie, Bouchard Doulakas, Géraldine, Carrupt, Pierre-Alain, Tillement, Jean-Paul, Labidalle, Serge, Morin, Didier

“…The mitochondrial effects of two fluoride curcumin derivatives were studied. They induced the collapse of mitochondrial membrane potential (Δψ), increased…”
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Ionic partition diagrams of ionisable drugs: pH-lipophilicity profiles, transfer mechanisms and charge effects on solvation by Reymond, Frédéric, Chopineaux-Courtois, Véronique, Steyaert, Guillaume, Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Girault, Hubert H

“…The transfer of a series of weak acids, bases and ampholytes has been studied by cyclic voltammetry at the water ∣ 1,2-dichloroethane interface in order to…”
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Cyclic voltammetry of highly hydrophilic ions at a supported liquid membrane by Ulmeanu, Sorina M, Jensen, Henrik, Samec, Zdenek, Bouchard, Géraldine, Carrupt, Pierre-Alain, Girault, Hubert H

“…Cyclic voltammetry has been used to study the coupling of ion transfer reactions at a liquid membrane. The liquids are either supported by a porous hydrophobic…”
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Theoretical and experimental exploration of the lipophilicity of zwitterionic drugs in the 1,2-dichloroethane/water system by BOUCHARD, Géraldine, PAGLIARA, Alessandra, CARRUPT, Pierre-Alain, TESTA, Bernard, GOBRY, Véronique, GIRAULT, Hubert H

“…This work examines the lipophilic behavior of various zwitterions and shows how distribution profiles in biphasic systems and ionic partition diagrams may…”
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Partition Coefficients of Ionizable Compounds in o-Nitrophenyl Octyl Ether/Water Measured by the Potentiometric Method by Liu, Xiangli, Bouchard, Géraldine, Girault, Hubert H, Testa, Bernard, Carrupt, Pierre-Alain

“…The objective of this study was to investigate the reliability of potentiometric measurements of partition coefficients (log P) in the o-NPOE/water system,…”
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Solvatochromic Analysis of Partition Coefficients in the o-Nitrophenyl Octyl Ether (o-NPOE)/Water System by Liu, Xiangli, Bouchard, Géraldine, Müller, Nathalie, Galland, Alexandra, Girault, Hubert, Testa, Bernard, Carrupt, Pierre-Alain

“…The objective of this study was to unravel the structural properties responsible for the partitioning of solutes in o‐nitrophenyl octyl ether (o‐NPOE)/H2O, a…”
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The apparent lipophilicity of quaternary ammonium ions is influenced by Galvani potential difference, not ion-pairing : A cyclic voltammetry study by BOUCHARD, Géraldine, CARRUPT, Pierre-Alain, TESTA, Bernard, GOBRY, Véronique, GIRAULT, Hubert H

“…This work examines whether ion-pairing contributes to the apparent lipophilicity of cations, which is seen by a shake-flask or titrimetic method to be…”
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Effects of Charge and Intramolecular Structure on the Lipophilicity of Nitrophenols by Chopineaux-Courtois, Véronique, Reymond, Frédéric, Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Girault, Hubert H

“…The lipophilicity of a series of phenolic compounds was studied in the 1,2-dichloroethane (1,2-DCE)/water system. Cyclic voltammetry at the ITIES was used to…”
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Ionic Partition Diagram of the Zwitterionic Antihistamine Cetirizine by Bouchard, Géraldine, Pagliara, Alessandra, van Balen, Georgette Plemper, Carrupt, Pierre-Alain, Testa, Bernard, Gobry, Véronique, Girault, Hubert H., Caron, Giulia, Ermondi, Giuseppe, Fruttero, Roberta

“…A recent analysis of the lipophilicity profile of cetirizine in the octanol/water and dodecane/water systems revealed a partial intramolecular charge…”
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Generalization of Ionic Partition Diagrams to Lipophilic Compounds and to Biphasic Systems with Variable Phase Volume Ratios by Gobry, Véronique, Ulmeanu, Sorina, Reymond, Frédéric, Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Girault, Hubert H

“…The ionic partition diagram methodology has been generalized to address both hydrophilic and lipophilic compounds and to consider biphasic systems with…”
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Exploration of the Pharmacophore of 3-Alkyl-5-Arylimidazolidinediones as New CB1 Cannabinoid Receptor Ligands and Potential Antagonists: Synthesis, Lipophilicity, Affinity, and Molecular Modeling by Ooms, Frédéric, Wouters, Johan, Oscari, Olivier, Happaerts, Thierry, Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Lambert, Didier M

“…A set of 29 3-alkyl 5-arylimidazolidinediones (hydantoins) with affinity for the human cannabinoid CB1 receptor was studied for their lipophilicity and…”
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Numerical simulation of two-phase partition chromatography in microchannels for moderated logP measurements by Ulmeanu, Sorina M., Josserand, Jacques, Jensen, Henrik, Bouchard, Géraldine, Carrupt, Pierre-Alain, Girault, Hubert H.

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The Lipophilicity Behavior of Three Catechol-O-methyltransferase (COMT) Inhibitors and Simple Analogues by Novaroli, Laura, Bouchard Doulakas, Geraldine, Reist, Marianne, Rolando, Barbara, Fruttero, Roberta, Gasco, Alberto, Carrupt, Pierre-Alain

“…The ionization and lipophilicity properties of the second‐generation catechol‐O‐methyltransferase (COMT) inhibitors entacapone (1), nitecapone (2), and…”
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Lipophilicity behaviour of the zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems by PLEMPER VAN BALEN, Georgette, CARON, Giulia, ERMONDI, Giuseppe, PAGLIARA, Alessandra, GRANDI, Teresa, BOUCHARD, Géraldine, FRUTTERO, Roberta, CARRUPT, Pierre-Alain, TESTA, Bernard

“…The partitioning of cetirizine in a phosphatidylcholine liposomes/water system was compared with that of hydroxyzine and acrivastine to gain insight into the…”
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Numerical simulation of two-phase partition chromatography in microchannels for moderated log P measurements by Ulmeanu, Sorina M., Josserand, Jacques, Jensen, Henrik, Bouchard, Géraldine, Carrupt, Pierre-Alain, Girault, Hubert H.

“…A finite element simulation has been used in order to study the partition chromatography process of one species between an aqueous mobile phase and an organic…”
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Exploration of the Pharmacophore of 3-Alkyl-5-arylimidazolidinediones as New CB 1 Cannabinoid Receptor Ligands and Potential Antagonists:  Synthesis, Lipophilicity, Affinity, and Molecular Modeling by Ooms, Frédéric, Wouters, Johan, Oscari, Olivier, Happaerts, Thierry, Bouchard, Géraldine, Carrupt, Pierre-Alain, Testa, Bernard, Lambert, Didier M.

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