Search Results - "Boucek Jr, R."

Doxorubicin Cardiotoxicity May Be Caused by Its Metabolite, Doxorubicinol by Olson, Richard D., Mushlin, Phillip S., Brenner, Dean E., Fleischer, Sidney, Cusack, Barry J., Chang, Barbara K., Boucek, Robert J.

“…Doxorubicin (former generic name, adriamycin), a highly effective anticancer drug, produces cardiotoxicity, which limits its therapeutic potential. The…”
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Cytomegalovirus infection and ganciclovir resistance caused by UL97 mutations in pediatric transplant recipients by Kim, Y.-J., Boeckh, M., Cook, L., Stempel, H., Jerome, K.R., Boucek Jr, R., Burroughs, L., Englund, J.A.

“…Background Cytomegalovirus (CMV) infection may cause serious disease after hematopoietic cell transplantation (HCT) and solid organ transplantation (SOT), but…”
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The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions by Boucek, R J, Olson, R D, Brenner, D E, Ogunbunmi, E M, Inui, M, Fleischer, S

“…Doxorubicin (adriamycin) is a highly effective cancer chemotherapeutic drug but its clinical utility is limited by its cardiotoxicity. Doxorubicinol, the major…”
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Sarcoplasmic Reticulum Calcium Release Is Stimulated and Inhibited by Daunorubicin and Daunorubicinol by Olson, Richard D., Li, Xuande, Palade, Philip, Shadle, Susan E., Mushlin, Phillip S., Gambliel, Herve A., Fill, Michael, Boucek, Robert J., Cusack, Barry J.

“…Cardiac effects of anthracyclines or their metabolites may include both the stimulation and inhibition of Ca2+ release from sarcoplasmic reticulum. In this…”
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Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart by BOUCEK, R. J. JR, SHELTON, M, ARTMAN, M, MUSHLIN, P. S, STARNES, V. A, OLSON, R. D

“…The effects of postnatal development on the systolic and diastolic responses to pharmacologic blockade of the slow inward calcium current were investigated in…”
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Myocardial Adenosine Triphosphate Content as a Measure of Metabolic and Functional Myocardial Protection in Children Undergoing Cardiac Operation by Hammon, John W., Graham, Thomas P., Boucek, Robert J., Parrish, Mark D., Merrill, Walter H., Bender, Harvey W.

“…In an effort to quantitate the metabolic and functional response to global myocardial ischemia as a prelude to specific interventions to improve myocardial…”
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Pathophysiology of chronic cyanosis in a canine model. Functional and metabolic response to global ischemia by Lupinetti, F M, Wareing, T H, Huddleston, C B, Collins, J C, Boucek, Jr, R J, Bender, Jr, H W, Hammon, Jr, J W

“…To investigate the pathophysiology of chronic cyanosis, we subjected 14 adult mongrel dogs to diversion of the inferior vena cava to the right inferior…”
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Effects of methoxamine and phenylephrine on left ventricular contractility in rabbits by Kronenberg, Marvin W., McCain, Robert W., Boucek, Robert J., Grambow, David W., Sagawa, Kiichi, Friesinger, Gottlieb C.

“…The end-systolic pressure-volume relation is employed to evaluate left ventricular contractility. In clinical studies, pharmacologic vasoconstriction is used…”
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Target size of the ryanodine receptor from junctional terminal cisternae of sarcoplasmic reticulum by McGrew, Susan G, Boucek, Robert J, McIntyre, J. Oliver, Jung, Chan Y, Fleischer, Sidney

“…Target inactivation analysis was carried out on the ryanodine receptor. This receptor recently has been implicated as the channel involved in the calcium…”
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Short-term hemodynamic effects of hydralazine in infants with complete atrioventricular canal defects by ARTMAN, M, PARRISH, M. D, BOERTH, R. C, BOUCEK, R. J. JR, GRAHAM, T. P. JR

“…We evaluated the acute hemodynamic responses to hydralazine during cardiac catheterization in eight infants (ages 1.0 to 5.5 months) with congestive heart…”
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Echocardiographic estimation of critical left ventricular size in infants with isolated aortic valve stenosis by Parsons, Mark K., Moreau, Gordon A., Graham, Thomas P., Johns, James A., Boucek, Robert J.

“…With the current trend to performing surgical valvotomy for infantile aortic stenosis without cardiac catheterization, there is a need to develop…”
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Surgical Management of Patients with Pulmonary Valve Dysplasia by Merrill, Walter H., Stewart, James R., Hammon, John W., Boucek, Robert J., Bender, Harvey W.

“…Pulmonary valve dysplasia is a distinct pathological entity consisting of markedly thickened, deformed, and largely immobile pulmonary valve leaflets. The…”
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Daunorubicin-induced cardiac injury in the rabbit: a role for daunorubicinol? by Cusack, B J, Mushlin, P S, Voulelis, L D, Li, X, Boucek, Jr, R J, Olson, R D

“…This study evaluated potential contributions of daunorubicin and its principle metabolite, daunorubicinol, to the cardiotoxicity of daunorubicin therapy…”
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Stem-like cells traffic from heart ex vivo, expand in vitro, and can be transplanted in vivo by Steele, A, Jones, O Y, Gok, F, Marikar, Y, Steele, P, Chamizo, W, Scott, M, Boucek, Jr, R J

“…Cells with stem cell surface markers have been identified in heart tissue. Early indications suggest that these are cardiac progenitor cells that could…”
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Myocardial dysfunction in children with acute meningococcemia by Boucek, M M, Boerth, R C, Artman, M, Graham, Jr, T P, Boucek, Jr, R J

“…Acute meningococcemia is frequently associated with cardiovascular collapse of uncertain cause. Review of the records of 12 consecutive children revealed…”
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Absence of left ventricular volume loading in infants with coarctation of the aorta and a large ventricular septal defect by Graham, Thomas P., Burger, Judith, Boucek, Robert J., Johns, James A., Moreau, Gordon A., Hammon, John W., Bender, Harvey W.

“…Clinical characteristics and angiographic ventricular volume data were obtained in 25 infants aged 1 to 66 days who presented with coarctation of the aorta,…”
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Persistent Effects of Doxorubicin on Cardiac Gene Expression by Boucek, Jr, Robert J, Miracle, Ann, Anderson, Michelle, Engelman, Robert, Atkinson, James, Dodd, Debra A

“…During administration of the anthracycline antitumour agents, their cardiotoxicity can progress from cardiac dysfunction to heart failure. Cardiomyopathy can…”
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Decreased early diastolic function after indomethacin administration in premature infants by Appleton, R S, Graham, Jr, T P, Cotton, R B, Moreau, G A, Boucek, Jr, R J

“…The effect of indomethacin on systolic and diastolic cardiac function was assessed in 15 premature infants. Seven infants (group 1) received indomethacin to…”
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Effects of postnatal maturation of postrest potentiation in isolated rabbit atria by BOUCEK, R. J. JR, CITAK, M, GRAHAM, T. P. JR, ARTMAN, M

“…Ultrastructural changes in cardiac sarcoplasmic reticulum (SR) have been reported during postnatal development of the mammalian heart, but the functional…”
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Induction immunotherapy in pediatric heart transplant recipients: a multicenter study by Boucek, Jr, R J, Naftel, D, Boucek, M M, Chinnock, R, Morrow, R W, Pahl, E, DiSano, S

“…The efficacy and safety of induction immunotherapy with antithymocyte antibody preparations (IND) in pediatric heart transplantation is controversial…”
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