Search Results - "Boucas, Jorge"

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage by Nava, Michele M., Miroshnikova, Yekaterina A., Biggs, Leah C., Whitefield, Daniel B., Metge, Franziska, Boucas, Jorge, Vihinen, Helena, Jokitalo, Eija, Li, Xinping, García Arcos, Juan Manuel, Hoffmann, Bernd, Merkel, Rudolf, Niessen, Carien M., Dahl, Kris Noel, Wickström, Sara A.

“…Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei,…”
Get full text

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression by Boucas, Jorge, Fritz, Christian, Schmitt, Anna, Riabinska, Arina, Thelen, Lisa, Peifer, Martin, Leeser, Uschi, Nuernberg, Peter, Altmueller, Janine, Gaestel, Matthias, Dieterich, Christoph, Reinhardt, H Christian

“…Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability programs. Additionally, recent developments in RNA sequencing…”
Get full text

Cytoscape Automation: empowering workflow-based network analysis by Otasek, David, Morris, John H, Bouças, Jorge, Pico, Alexander R, Demchak, Barry

“…Cytoscape is one of the most successful network biology analysis and visualization tools, but because of its interactive nature, its role in creating…”
Get full text

Heparan Sulfate Proteoglycan Binding Properties of Adeno-Associated Virus Retargeting Mutants and Consequences for Their In Vivo Tropism by PERABO, Luca, GOLDNAU, Daniela, BÜNING, Hildegard, WHITE, Kathryn, ENDELL, Jan, BOUCAS, Jorge, HUMME, Sibille, WORK, Lorraine M, JANICKI, Hanna, HALLEK, Michael, BAKER, Andrew H

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

ER-associated RNA silencing promotes ER quality control by Efstathiou, Sotirios, Ottens, Franziska, Schütter, Lena-Sophie, Ravanelli, Sonia, Charmpilas, Nikolaos, Gutschmidt, Aljona, Le Pen, Jérémie, Gehring, Niels H., Miska, Eric A., Bouças, Jorge, Hoppe, Thorsten

“…The endoplasmic reticulum (ER) coordinates mRNA translation and processing of secreted and endomembrane proteins. ER-associated degradation (ERAD) prevents the…”
Get full text

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor by Reinart, Nina, Nguyen, Phuong-Hien, Boucas, Jorge, Rosen, Natascha, Kvasnicka, Hans-Michael, Heukamp, Lukas, Rudolph, Cornelia, Ristovska, Vangica, Velmans, Tanja, Mueller, Carolin, Reiners, Katrin S., von Strandmann, Elke Pogge, Krause, Günter, Montesinos-Rongen, Manuel, Schlegelberger, Brigitte, Herling, Marco, Hallek, Michael, Fingerle-Rowson, Günter

“…Survival of chronic lymphocytic leukemia (CLL) cells depends on stimuli provided by a suitable microenvironment. The factors and mechanisms providing this…”
Get full text

Therapeutic targeting of a robust non-oncogene addiction to PRKDC in ATM-defective tumors by Riabinska, Arina, Daheim, Mathias, Herter-Sprie, Grit S, Winkler, Johannes, Fritz, Christian, Hallek, Michael, Thomas, Roman K, Kreuzer, Karl-Anton, Frenzel, Lukas P, Monfared, Parisa, Martins-Boucas, Jorge, Chen, Shuhua, Reinhardt, Hans Christian

“…When the integrity of the genome is threatened, cells activate a complex, kinase-based signaling network to arrest the cell cycle, initiate DNA repair, or, if…”
Get more information

Pharmacologic interception in T-cell leukemia 1A associated pathways as a treatment rationale for chronic lymphocytic leukemia by Popal, Wagma, Boucas, Jorge, Peer-Zada, Abdul Ali, Herling, Marco

“…Recent therapeutic advances in chronic lymphocytic leukemia (CLL) are reflected by high response rates in most subsets of patients. However, refractory disease…”
Get full text

Engineering adeno-associated virus serotype 2-based targeting vectors using a new insertion site-position 453-and single point mutations by Boucas, Jorge, Lux, Kerstin, Huber, Anke, Schievenbusch, Stephanie, von Freyend, Miriam John, Perabo, Luca, Quadt-Humme, Sibille, Odenthal, Margarete, Hallek, Michael, Büning, Hildegard

“…Background Genetic modification of capsid proteins by peptide insertion has created the possibility of using adeno‐associated viral (AAV) vectors for receptor…”
Get full text

Posttranscriptional regulation of gene expression-adding another layer of complexity to the DNA damage response by Boucas, Jorge, Riabinska, Arina, Jokic, Mladen, Herter-Sprie, Grit S, Chen, Shuhua, Höpker, Katja, Reinhardt, H Christian

“…In response to DNA damage, cells activate a complex, kinase-based signaling network to arrest the cell cycle and allow time for DNA repair, or, if the extend…”
Get full text

Stroma-Induced TCL1 Expression In Chronic Lymphocytic Leukemia Cells Is Associated with Down Regulation of TCL1A-Targeting miRNAs by Sivina, Mariela, Hartmann, Elena, Boucas, Jorge, Keating, Michael J, Wierda, William G., Herling, Marco, Rosenwald, Andreas, Burger, Jan A.

“…Abstract 52 The T cell leukemia/lymphoma 1 (TCL1) oncogene was initially identified as a target of chromosomal translocations and inversions at the 14q32.1…”
Get full text

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression: e0125745 by Boucas, Jorge, Fritz, Christian, Schmitt, Anna, Riabinska, Arina, Thelen, Lisa, Peifer, Martin, Leeser, Uschi, Nuernberg, Peter, Altmueller, Janine, Gaestel, Matthias

“…Growing evidence suggests a key role for RNA binding proteins (RBPs) in genome stability programs. Additionally, recent developments in RNA sequencing…”
Get full text