Search Results - "Bouaziz, Zouhair"

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018 by Issa, Samar, Prandina, Anthony, Bedel, Nicolas, Rongved, Pål, Yous, Saïd, Le Borgne, Marc, Bouaziz, Zouhair

“…For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic…”
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Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles by Kita, Diogo Henrique, Guragossian, Nathalie, Zattoni, Ingrid Fatima, Moure, Vivian Rotuno, Rego, Fabiane Gomes de Moraes, Lusvarghi, Sabrina, Moulenat, Thomas, Belhani, Billel, Picheth, Geraldo, Bouacida, Sofiane, Bouaziz, Zouhair, Marminon, Christelle, Berredjem, Malika, Jose, Joachim, Gonçalves, Marcos Brown, Ambudkar, Suresh V., Valdameri, Glaucio, Le Borgne, Marc

“…The ATP-binding cassette transporter ABCG2 mediates the efflux of several chemotherapeutic drugs, contributing to the development of multidrug resistance (MDR)…”
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Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies by Sid, Dounia, Baitiche, Milad, Elbahri, Zineb, Djerboua, Ferhat, Boutahala, Mokhtar, Bouaziz, Zouhair, Le Borgne, Marc

“…The aim of this study was to prepare and characterise inclusion complexes of a low water-soluble drug, mefenamic acid (MA), with β-cyclodextrin (β-CD). First,…”
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Microwave-accelerated multicomponent synthesis and X-ray characterization of novel benzothiadiazinone dioxide derivatives, analogues of Monastrol by Bouzina, Abdeslem, Berredjem, Malika, Belhani, Billel, Bouacida, Sofiane, Marminon, Christelle, Le Borgne, Marc, Bouaziz, Zouhair, Aissaoui, Mohamed

“…We demonstrate here a rapid and comfortable synthetic sequence to benzothiadiazinone dioxide (six-membered cyclic sulfamide) derivatives, analogues of…”
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QSAR Model of Indeno[1,2- b ]indole Derivatives and Identification of N -isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3- b ]furan-3-carboxamide as a Potent CK2 Inhibitor by Haidar, Samer, Marminon, Christelle, Aichele, Dagmar, Nacereddine, Abdelhamid, Zeinyeh, Wael, Bouzina, Abdeslem, Berredjem, Malika, Ettouati, Laurent, Bouaziz, Zouhair, Le Borgne, Marc, Jose, Joachim

“…Casein kinase II (CK2) is an intensively studied enzyme, involved in different diseases, cancer in particular. Different scaffolds were used to develop…”
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Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor by El-Awaad, Ehab, Birus, Robin, Marminon, Christelle, Bouaziz, Zouhair, Ballentin, Laurens, Aichele, Dagmar, Le Borgne, Marc, Jose, Joachim

“…Protein kinase CK2 is involved in regulating cellular processes, such as cell cycle, proliferation, migration, and apoptosis, making it an attractive…”
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Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates by Bouzina, Abdeslem, Bechlem, Khaoula, Berredjem, Hajira, Belhani, Billel, Becheker, Imène, Lebreton, Jacques, Le Borgne, Marc, Bouaziz, Zouhair, Marminon, Christelle, Berredjem, Malika

“…Several new sulfamidocarbonyloxyphosphonates were prepared in two steps, namely carbamoylation and sulfamoylation, by using chlorosulfonyl isocyanate (CSI),…”
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Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining by Haidar, Samer, Bouaziz, Zouhair, Marminon, Christelle, Laitinen, Tuomo, Poso, Antti, Le Borgne, Marc, Jose, Joachim

“…Protein kinase CK2, initially designated as casein kinase 2, is an ubiquitously expressed serine/threonine kinase. This enzyme, implicated in many cellular…”
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Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds by Bloch, Sylwia, Nejman-Faleńczyk, Bożena, Pierzynowska, Karolina, Piotrowska, Ewa, Węgrzyn, Alicja, Marminon, Christelle, Bouaziz, Zouhair, Nebois, Pascal, Jose, Joachim, Le Borgne, Marc, Saso, Luciano, Węgrzyn, Grzegorz

“…Oxidative stress may be the major cause of induction of Shiga toxin-converting (Stx) prophages from chromosomes of Shiga toxin-producing Escherichia coli…”
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Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α by Hochscherf, Jennifer, Lindenblatt, Dirk, Witulski, Benedict, Birus, Robin, Aichele, Dagmar, Marminon, Christelle, Bouaziz, Zouhair, Le Borgne, Marc, Jose, Joachim, Niefind, Karsten

“…Protein kinase CK2, a member of the eukaryotic protein kinase superfamily, is associated with cancer and other human pathologies and thus an attractive drug…”
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Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes by Bouchouit, Mehdi, Bouacida, Sofiane, Zouchoune, Bachir, Merazig, Hocine, Bua, Silvia, Bouaziz, Zouhair, Le Borgne, Marc, Supuran, Claudiu T., Bouraiou, Abdelmalek

“…Three coordination compounds of formula {M(bmim) 2 Cl 2 } were synthetised (M = Co, Zn, and Hg) and fully characterised. Each complex incorporates…”
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Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures by Lindenblatt, Dirk, Nickelsen, Anna, Applegate, Violetta M, Hochscherf, Jennifer, Witulski, Benedict, Bouaziz, Zouhair, Marminon, Christelle, Bretner, Maria, Le Borgne, Marc, Jose, Joachim, Niefind, Karsten

“…CK2α and CK2α′ are the two isoforms of the catalytic subunit of human protein kinase CK2, an important target for cancer therapy. They have similar, albeit not…”
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Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2 by Alchab, Faten, Ettouati, Laurent, Bouaziz, Zouhair, Bollacke, Andre, Delcros, Jean-Guy, Gertzen, Christoph G W, Gohlke, Holger, Pinaud, Noël, Marchivie, Mathieu, Guillon, Jean, Fenet, Bernard, Jose, Joachim, Borgne, Marc Le

“…Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2…”
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Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7 by Nacereddine, Abdelhamid, Bollacke, Andre, Róka, Eszter, Marminon, Christelle, Bouaziz, Zouhair, Fenyvesi, Ferenc, Bácskay, Ildikó Katalin, Jose, Joachim, Perret, Florent, Le Borgne, Marc

“…Since the approval of imatinib in 2001, kinase inhibitors have revolutionized cancer therapies. Inside this family of phosphotransferases, casein kinase 2…”
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Crystal structure of 13-(2-methoxyphenyl)-3,4-dihydro-2H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione by Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Zouhair Bouaziz

“…In the title compound, C22H18N2O4, the three fused rings of the pyrazolophthalazine moiety are coplanar (r.m.s. deviation = 0.027 Å). The cyclohexene ring…”
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Methyl 3-(Quinolin-2-yl)indolizine-1-carboxylate by Belguedj, Roumaissa, Lamera, Esma, Bouraiou, Abdelmalek, Bouaziz, Zouhair, Chibani, Aissa

“…A novel compound, methyl 3-(quinolin-2-yl)indolizine-1-carboxylate (2) has been synthesized by cycloaddition reaction of 1-(quinolin-2-ylmethyl)pyridinium…”
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Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1H-indazolo[1,2-b]phthalazine-1,6,11-trione by Esma Lamera, Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, Aissa Chibani, Marc Le Borgne, Zouhair Bouaziz

“…The title compound, C21H16N2O3, consists of an indazolone moiety, bearing a phenyl group, fused to a phthalazine ring system (r.m.s. deviation = 0.018 Å). The…”
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Synthesis and Diels–Alder Reactivity of ortho-Carbazolequinones by Compain-Batissou, Muriel, Latreche, Djamila, Gentili, Jacques, Walchshofer, Nadia, Bouaziz, Zouhair

“…Oxidation of 2- and 3-hydroxycarbazoles with Frémy's salt gave the corresponding ortho-carbazolequinones. These molecules react as carbodienophiles in…”
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Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion by Bouzina, Abdeslem, Berredjem, Malika, Nocentini, Alessio, Bua, Silvia, Bouaziz, Zouhair, Jose, Joachim, Le Borgne, Marc, Marminon, Christelle, Gratteri, Paola, Supuran, Claudiu T.

“…Ninhydrins show extensive application in organic chemistry and agriculture whereas they have been poorly investigated as bioactive molecules for medicinal…”
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Carbazolequinone induction of caspase-dependent cell death in Src-overexpressing cells by Aouacheria, Abdel, Néel, Benjamin, Bouaziz, Zouhair, Dominique, Rigal, Walchshofer, Nadia, Paris, Joëlle, Fillion, Houda, Gillet, Germain

“…We previously reported that RSV-transformed quail neuroretina cells (QNR-ts68) were highly resistant to apoptosis provoked by serum withdrawal, and that this…”
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