The clinical validation of a dried blood spot method for simultaneous measurement of cyclosporine A, tacrolimus, creatinine, and hematocrit

•A multicomponent dried blood spot method was clinically validated in transplant recipients.•A dried blood spot method was validated for cyclosporine A, tacrolimus, creatinine and hematocrit.•A correction for hematocrit is needed for clinical use of dried blood spot for cyclosporine A and tacrolimus...

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Bibliographic Details
Published in:	Clinica chimica acta Vol. 535; pp. 131 - 139
Main Authors:	Francke, Marith I., van Domburg, Bart, Bouarfa, Samah, van de Velde, Daan, Hellemons, Merel E., Manintveld, Olivier C., Last-Koopmans, Suzanne, Mulder, Midas B., Hesselink, Dennis A., de Winter, Brenda C.M.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-10-2022
Subjects:	Creatinine Dried blood spot Hematocrit Immunosuppression Therapeutic drug monitoring Transplantation Creatinine Therapeutic drug monitoring Immunosuppression Transplantation Dried blood spot Hematocrit
Online Access:	Get full text
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Summary:	•A multicomponent dried blood spot method was clinically validated in transplant recipients.•A dried blood spot method was validated for cyclosporine A, tacrolimus, creatinine and hematocrit.•A correction for hematocrit is needed for clinical use of dried blood spot for cyclosporine A and tacrolimus.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-8981 1873-3492
DOI:	10.1016/j.cca.2022.08.014