Search Results - "Botten, Giovanni A"

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling by Wang, Zhaoning, Cui, Miao, Shah, Akansha M., Ye, Wenduo, Tan, Wei, Min, Yi-Li, Botten, Giovanni A., Shelton, John M., Liu, Ning, Bassel-Duby, Rhonda, Olson, Eric N.

“…The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after…”
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Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers by Hashimoto, Hisayuki, Wang, Zhaoning, Garry, Glynnis A., Malladi, Venkat S., Botten, Giovanni A., Ye, Wenduo, Zhou, Huanyu, Osterwalder, Marco, Dickel, Diane E., Visel, Axel, Liu, Ning, Bassel-Duby, Rhonda, Olson, Eric N.

“…The cardiogenic transcription factors (TFs) Mef2c, Gata4, and Tbx5 can directly reprogram fibroblasts to induced cardiac-like myocytes (iCLMs), presenting a…”
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Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia by Gu, Zhimin, Liu, Yuxuan, Zhang, Yuannyu, Cao, Hui, Lyu, Junhua, Wang, Xun, Wylie, Annika, Newkirk, Simon J., Jones, Amanda E., Lee, Michael, Botten, Giovanni A., Deng, Mi, Dickerson, Kathryn E., Zhang, Cheng Cheng, An, Wenfeng, Abrams, John M., Xu, Jian

“…Transposable elements or transposons are major players in genetic variability and genome evolution. Aberrant activation of long interspersed element-1 (LINE-1…”
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Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9 by Liu, Xin, Chen, Yong, Zhang, Yuannyu, Liu, Yuxuan, Liu, Nan, Botten, Giovanni A, Cao, Hui, Orkin, Stuart H, Zhang, Michael Q, Xu, Jian

“…The spatiotemporal control of 3D genome is fundamental for gene regulation, yet it remains challenging to profile high-resolution chromatin structure at…”
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Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture by Cha, Hye Ji, Uyan, Özgün, Kai, Yan, Liu, Tianxin, Zhu, Qian, Tothova, Zuzana, Botten, Giovanni A., Xu, Jian, Yuan, Guo-Cheng, Dekker, Job, Orkin, Stuart H.

“…Precise control of gene expression during differentiation relies on the interplay of chromatin and nuclear structure. Despite an established contribution of…”
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Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense by Scumpia, Philip O, Botten, Giovanni A, Norman, Joshua S, Kelly-Scumpia, Kindra M, Spreafico, Roberto, Ruccia, Amber R, Purbey, Prabhat K, Thomas, Brandon J, Modlin, Robert L, Smale, Stephen T

“…Successful host defense against pathogens requires innate immune recognition of the correct pathogen associated molecular patterns (PAMPs) by pathogen…”
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Pathogenic human variant that dislocates GATA2 zinc fingers disrupts hematopoietic gene expression and signaling networks by Jung, Mabel Minji, Shen, Siqi, Botten, Giovanni A, Olender, Thomas, Katsumura, Koichi R, Johnson, Kirby D, Soukup, Alexandra A, Liu, Peng, Zhang, Qingzhou, Jensvold, Zena D, Lewis, Peter W, Beagrie, Robert A, Low, Jason Kk, Yang, Lihua, Mackay, Joel P, Godley, Lucy A, Brand, Marjorie, Xu, Jian, Keles, Sunduz, Bresnick, Emery H

“…Although certain human genetic variants are conspicuously loss of function, decoding the impact of many variants is challenging. Previously, we described a…”
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Cell Surface N-Glycans Influence Electrophysiological Properties and Fate Potential of Neural Stem Cells by Yale, Andrew R., Nourse, Jamison L., Lee, Kayla R., Ahmed, Syed N., Arulmoli, Janahan, Jiang, Alan Y.L., McDonnell, Lisa P., Botten, Giovanni A., Lee, Abraham P., Monuki, Edwin S., Demetriou, Michael, Flanagan, Lisa A.

“…Understanding the cellular properties controlling neural stem and progenitor cell (NSPC) fate choice will improve their therapeutic potential. The…”
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Dissecting Locus-Specific Chromatin Interactions by CRISPR CAPTURE by Botten, Giovanni A, Lee, Jr, Michael, Xu, Jian

“…The spatiotemporal control of tissue-specific gene expression is coordinated by cis-regulatory elements (CREs) and associated trans-acting factors. Despite…”
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Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering by Arulmoli, Janahan, Wright, Heather J., Phan, Duc T.T., Sheth, Urmi, Que, Richard A., Botten, Giovanni A., Keating, Mark, Botvinick, Elliot L., Pathak, Medha M., Zarembinski, Thomas I., Yanni, Daniel S., Razorenova, Olga V., Hughes, Christopher C.W., Flanagan, Lisa A.

“…[Display omitted] Human neural stem/progenitor cells (hNSPCs) are good candidates for treating central nervous system (CNS) trauma since they secrete…”
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T/myeloid mixed phenotype acute leukaemia harbouring TLX3::BCL11B with TLX3 activation by Botten, Giovanni A., Zhang, Yuannyu, Fuda, Franklin, Koduru, Prasad, Weinberg, Olga K., Slone, Tamra L., Zheng, Ruifang, Dickerson, Kathryn E., Gagan, Jeffrey R., Chen, Weina

“…Summary T/myeloid mixed phenotype acute leukaemia (MPAL) is a rare aggressive acute leukaemia with poorly understood pathogenesis. Herein, we report two cases…”
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Structural variation cooperates with permissive chromatin to control enhancer hijacking–mediated oncogenic transcription by Botten, Giovanni A., Zhang, Yuannyu, Dudnyk, Kseniia, Kim, Yoon Jung, Liu, Xin, Sanders, Jacob T., Imanci, Aygun, Droin, Nathalie, Cao, Hui, Kaphle, Pranita, Dickerson, Kathryn E., Kumar, Kirthi R., Chen, Mingyi, Chen, Weina, Solary, Eric, Ly, Peter, Zhou, Jian, Xu, Jian

“…•We describe a multimodal approach for quantitative analysis of transcriptional and structural impacts imposed by structural variants.•Enhancer hijacking…”
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Detection of viral gene expression in risk‐stratified biopsies reveals no active HPV in cutaneous squamous cell carcinoma by Vandiver, Amy R., Thomas, Brandon J., Karimzada, Mohammad, Knowles, Byron C., Botten, Giovanni A., Spreafico, Roberto, Rotman, Jeremy N., Gharavi, Nima M, Chesnut, Cameron, Wesel, Kevin, Mangul, Serghei, Soriano, Teresa, Scumpia, Philip O.

“…Background Human papillomavirus (HPV) infection is known to promote the development of mucosal squamous cell carcinoma (mSCC), including pathologically…”
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Light-activated macromolecular phase separation modulates transcription by reconfiguring chromatin interactions by Kim, Yoon Jung, Lee, Jr, Michael, Lee, Yi-Tsang, Jing, Ji, Sanders, Jacob T, Botten, Giovanni A, He, Lian, Lyu, Junhua, Zhang, Yuannyu, Mettlen, Marcel, Ly, Peter, Zhou, Yubin, Xu, Jian

“…Biomolecular condensates participate in the regulation of gene transcription, yet the relationship between nuclear condensation and transcriptional activation…”
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Genetic and Epigenetic Dysregulation of Transcriptional Enhancers in Cancer by Botten, Giovanni A., Xu, Jian

“…Enhancers are noncoding DNA sequences responsible for orchestrating gene expression programs by interacting with transcription factors and chromatin regulators…”
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Targeting Cell Adhesion Molecules in IDH Mutant Myeloid Malignances by Lyu, Junhua, Liu, Yuxuan, Zhang, Yuannyu, Cai, Feng, Botten, Giovanni A., Cao, Hui, Kaphle, Pranita, Deberardinis, Ralph J, Xu, Jian

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Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription by Botten, Giovanni A., Zhang, Yuannyu, Dudnyk, Kseniia, Liu, Xin, Sanders, Jacob T., Imanci, Aygun, Droin, Nathalie, Cao, Hui, Kaphle, Pranita, Dickerson, Kathryn E., Chen, Mingyi, Chen, Weina, Solary, Eric, Ly, Peter, Zhou, Jian, Xu, Jian

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