Search Results - "Bottcher, S."

Ultra-long-acting insulin degludec has a flat and stable glucose-lowering effect in type 2 diabetes by Heise, T., Nosek, L., Bøttcher, S. G., Hastrup, H., Haahr, H.

“…Aims Insulin degludec (IDeg) is a new‐generation, ultra‐long‐acting basal insulin that forms soluble multihexamers upon subcutaneous injection, resulting in a…”
Get full text

The Radiation Assessment Detector (RAD) Investigation by Hassler, D. M., Zeitlin, C., Wimmer-Schweingruber, R. F., Böttcher, S., Martin, C., Andrews, J., Böhm, E., Brinza, D. E., Bullock, M. A., Burmeister, S., Ehresmann, B., Epperly, M., Grinspoon, D., Köhler, J., Kortmann, O., Neal, K., Peterson, J., Posner, A., Rafkin, S., Seimetz, L., Smith, K. D., Tyler, Y., Weigle, G., Reitz, G., Cucinotta, F. A.

“…The Radiation Assessment Detector (RAD) on the Mars Science Laboratory (MSL) is an energetic particle detector designed to measure a broad spectrum of…”
Get full text

International standardized approach for flow cytometric residual disease monitoring in chronic lymphocytic leukaemia by RAWSTRON, A. C, VILLAMOR, N, EVAN, P. A. S, NATKUNAM, Y, COUTRE, S. E, AVERY, E. D, RASSENTI, L. Z, KIPPS, T. J, CALIGARIS-CAPPIO, F, KNEBA, M, BYRD, J. C, HALLEK, M. J, RITGEN, M, MONTSERRAT, E, HILLMEN, P, BÖTTCHER, S, GHIA, P, ZEHNDER, J. L, LOZANSKI, G, COLOMER, D, MORENO, C, GEUNA, M

“…The eradication of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL) predicts for improved outcome. However, the wide variety of MRD…”
Get full text

Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping by Costa, E S, Pedreira, C E, Barrena, S, Lecrevisse, Q, Flores, J, Quijano, S, Almeida, J, del Carmen García- Macias, M, Bottcher, S, Van Dongen, J J M, Orfao, A

“…Immunophenotypic characterization of B-cell chronic lymphoproliferative disorders (B-CLPD) is becoming increasingly complex due to usage of progressively…”
Get full text

Measurements of the neutron spectrum on the Martian surface with MSL/RAD by Köhler, J., Zeitlin, C., Ehresmann, B., Wimmer-Schweingruber, R. F., Hassler, D. M., Reitz, G., Brinza, D. E., Weigle, G., Appel, J., Böttcher, S., Böhm, E., Burmeister, S., Guo, J., Martin, C., Posner, A., Rafkin, S., Kortmann, O.

“…The Radiation Assessment Detector (RAD), onboard the Mars Science Laboratory (MSL) rover Curiosity, measures the energetic charged and neutral particles and…”
Get full text

Recurrent CIR-accelerated ions observed by STEREO SEPT by Gómez-Herrero, R., Klassen, A., Müller-Mellin, R., Heber, B., Wimmer-Schweingruber, R., Böttcher, S.

“…Fast solar wind streams originating from coronal holes interact with the preceding slow wind, leading to the formation of corotating interaction regions (CIRs)…”
Get full text

Flow cytometric immunobead assay for the detection of BCR-ABL fusion proteins in leukemia patients by Weerkamp, F, Dekking, E, Ng, Y Y, van der Velden, V H J, Wai, H, Böttcher, S, Brüggemann, M, van der Sluijs, A J, Koning, A, Boeckx, N, Van Poecke, N, Lucio, P, Mendonça, A, Sedek, L, Szczepański, T, Kalina, T, Kovac, M, Hoogeveen, P G, Flores-Montero, J, Orfao, A, Macintyre, E, Lhermitte, L, Chen, R, Brouwer-De Cock, K A J, van der Linden, A, Noordijk, A L, Comans-Bitter, W M, Staal, F J T, van Dongen, J J M

“…BCR–ABL fusion proteins show increased signaling through their ABL tyrosine kinase domain, which can be blocked by specific inhibitors, thereby providing…”
Get full text

EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols by Kalina, T, Flores-Montero, J, van der Velden, V H J, Martin-Ayuso, M, Böttcher, S, Ritgen, M, Almeida, J, Lhermitte, L, Asnafi, V, Mendonça, A, de Tute, R, Cullen, M, Sedek, L, Vidriales, M B, Pérez, J J, te Marvelde, J G, Mejstrikova, E, Hrusak, O, Szczepański, T, van Dongen, J J M, Orfao, A

“…The EU-supported EuroFlow Consortium aimed at innovation and standardization of immunophenotyping for diagnosis and classification of hematological…”
Get full text

Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory by Zeitlin, C., Hassler, D. M., Cucinotta, F. A., Ehresmann, B., Wimmer-Schweingruber, R. F., Brinza, D. E., Kang, S., Weigle, G., Böttcher, S., Böhm, E., Burmeister, S., Guo, J., Köhler, J., Martin, C., Posner, A., Rafkin, S., Reitz, G.

“…The Mars Science Laboratory spacecraft, containing the Curiosity rover, was launched to Mars on 26 November 2011, and for most of the 253-day,…”
Get full text

EuroFlow antibody panels for standardized n-dimensional flow cytometric immunophenotyping of normal, reactive and malignant leukocytes by van Dongen, J J M, Lhermitte, L, Böttcher, S, Almeida, J, van der Velden, V H J, Flores-Montero, J, Rawstron, A, Asnafi, V, Lécrevisse, Q, Lucio, P, Mejstrikova, E, Szczepański, T, Kalina, T, de Tute, R, Brüggemann, M, Sedek, L, Cullen, M, Langerak, A W, Mendonça, A, Macintyre, E, Martin-Ayuso, M, Hrusak, O, Vidriales, M B, Orfao, A

“…Most consensus leukemia & lymphoma antibody panels consist of lists of markers based on expert opinions, but they have not been validated. Here we present the…”
Get full text

Minimal residual disease detection in mantle cell lymphoma: methods and significance of four-color flow cytometry compared to consensus IGH-polymerase chain reaction at initial staging and for follow-up examinations by Bottcher, Sebastian, Ritgen, Matthias, Buske, Sebastian, Gesk, Stefan, Klapper, Wolfram, Hoster, Eva, Hiddemann, Wolfgang, Unterhalt, Michael, Dreyling, Martin, Siebert, Reiner, Kneba, Michael, Pott, Christiane, on behalf of EU MCL MRD Group

“…1 University of Schleswig-Holstein, Campus Kiel, 2nd Department of Medicine, Kiel; 2 University of Schleswig-Holstein, Campus Kiel, Institute of Human…”
Get full text

Next Generation Flow for highly sensitive and standardized detection of minimal residual disease in multiple myeloma by Flores-Montero, J, Sanoja-Flores, L, Paiva, B, Puig, N, García-Sánchez, O, Böttcher, S, van der Velden, V H J, Pérez-Morán, J-J, Vidriales, M-B, García-Sanz, R, Jimenez, C, González, M, Martínez-López, J, Corral-Mateos, A, Grigore, G-E, Fluxá, R, Pontes, R, Caetano, J, Sedek, L, del Cañizo, M-C, Bladé, J, Lahuerta, J-J, Aguilar, C, Bárez, A, García-Mateo, A, Labrador, J, Leoz, P, Aguilera-Sanz, C, San-Miguel, J, Mateos, M-V, Durie, B, van Dongen, J J M, Orfao, A

“…Flow cytometry has become a highly valuable method to monitor minimal residual disease (MRD) and evaluate the depth of complete response (CR) in bone marrow…”
Get full text

Improving efficiency and sensitivity: European Research Initiative in CLL (ERIC) update on the international harmonised approach for flow cytometric residual disease monitoring in CLL by Rawstron, A C, Böttcher, S, Letestu, R, Villamor, N, Fazi, C, Kartsios, H, de Tute, R M, Shingles, J, Ritgen, M, Moreno, C, Lin, K, Pettitt, A R, Kneba, M, Montserrat, E, Cymbalista, F, Hallek, M, Hillmen, P, Ghia, P

“…Detection of minimal residual disease (MRD) in chronic lymphocytic leukaemia (CLL) is becoming increasingly important as treatments improve. An internationally…”
Get full text

Understanding the origin of band gap formation in graphene on metals: graphene on Cu/Ir(111) by Vita, H., Böttcher, S., Horn, K., Voloshina, E. N., Ovcharenko, R. E., Kampen, Th, Thissen, A., Dedkov, Yu. S.

“…Understanding the nature of the interaction at the graphene/metal interfaces is the basis for graphene-based electron- and spin-transport devices. Here we…”
Get full text

Structural and electronic properties of the graphene/Al/Ni(111) intercalation system by Voloshina, E N, Generalov, A, Weser, M, Böttcher, S, Horn, K, Dedkov, Yu S

Get full text

Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial by Hallek, M, Prof, Fischer, K, MD, Fingerle-Rowson, G, MD, Fink, AM, MD, Busch, R, Mayer, J, Prof, Hensel, M, Prof, Hopfinger, G, MD, Hess, G, MD, von Grünhagen, U, MD, Bergmann, M, MD, Catalano, J, MD, Zinzani, PL, Prof, Caligaris-Cappio, F, Prof, Seymour, JF, Prof, Berrebi, A, Prof, Jäger, U, Prof, Cazin, B, MD, Trneny, M, MD, Westermann, A, Wendtner, CM, Prof, Eichhorst, BF, MD, Staib, P, MD, Bühler, A, MD, Winkler, D, MD, Zenz, T, MD, Böttcher, S, MD, Ritgen, M, MD, Mendila, M, MD, Kneba, M, Prof, Döhner, H, Prof, Stilgenbauer, S, Prof

“…Summary Background On the basis of promising results that were reported in several phase 2 trials, we investigated whether the addition of the monoclonal…”
Get full text

Automated pattern-guided principal component analysis vs expert-based immunophenotypic classification of B-cell chronic lymphoproliferative disorders: a step forward in the standardization of clinical immunophenotyping by Costa, E.S, Pedreira, C.E, Barrena, S, Lecrevisse, Q, Flores, J, Quijano, S, Almeida, J, del Carmen Garcia-Macias, M, Bottcher, S, Van Dongen, J.J.M, Orfao, A

Get full text

Off-flavour masking of secondary lipid oxidation products by pea dextrin by Böttcher, S., Steinhäuser, U., Drusch, S.

“…•Pea dextrin efficiently masks propanal, 1-penten-3-one, hexanal and (E,E)-2,4-heptadienal.•Off-flavour in emulsions was significantly reduced by pea…”
Get full text

Standardized MRD flow and ASO IGH RQ-PCR for MRD quantification in CLL patients after rituximab-containing immunochemotherapy: a comparative analysis by Böttcher, S, Stilgenbauer, S, Busch, R, Brüggemann, M, Raff, T, Pott, C, Fischer, K, Fingerle-Rowson, G, Döhner, H, Hallek, M, Kneba, M, Ritgen, M

“…Rituximab-containing regimens are becoming a therapeutic standard in chronic lymphocytic leukemia (CLL), so that a validation of flow cytometric minimal…”
Get full text

Calibration and Characterization of the Radiation Assessment Detector (RAD) on Curiosity by Zeitlin, C., Hassler, D. M., Wimmer-Schweingruber, R. F., Ehresmann, B., Appel, J., Berger, T., Böhm, E., Böttcher, S., Brinza, D. E., Burmeister, S., Guo, J., Köhler, J., Lohf, H., Martin, C., Matthiä, D., Posner, A., Rafkin, S., Reitz, G., Tyler, Y. D., Vincent, M., Weigle, G., Iwata, Y., Kitamura, H., Murakami, T.

“…The Radiation Assessment Detector, RAD, is one of the ten instruments that make up the science payload of the Mars Science Laboratory Curiosity rover. RAD is…”
Get full text