Search Results - "Bottcher, Chotima"

Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction by Priller, Josef, Böttcher, Chotima

“…A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis…”
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Mapping microglia states in the human brain through the integration of high-dimensional techniques by Sankowski, Roman, Böttcher, Chotima, Masuda, Takahiro, Geirsdottir, Laufey, Sagar, Sindram, Elena, Seredenina, Tamara, Muhs, Andreas, Scheiwe, Christian, Shah, Mukesch Johannes, Heiland, Dieter Henrik, Schnell, Oliver, Grün, Dominic, Priller, Josef, Prinz, Marco

“…Microglia are tissue-resident macrophages of the CNS that orchestrate local immune responses and contribute to several neurological and psychiatric diseases…”
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Novel Hexb-based tools for studying microglia in the CNS by Masuda, Takahiro, Amann, Lukas, Sankowski, Roman, Staszewski, Ori, Lenz, Maximilian, d´Errico, Paolo, Snaidero, Nicolas, Costa Jordão, Marta Joana, Böttcher, Chotima, Kierdorf, Katrin, Jung, Steffen, Priller, Josef, Misgeld, Thomas, Vlachos, Andreas, Meyer-Luehmann, Melanie, Knobeloch, Klaus-Peter, Prinz, Marco

“…Microglia and central nervous system (CNS)-associated macrophages (CAMs), such as perivascular and meningeal macrophages, are implicated in virtually all…”
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Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution by Masuda, Takahiro, Sankowski, Roman, Staszewski, Ori, Böttcher, Chotima, Amann, Lukas, Sagar, Scheiwe, Christian, Nessler, Stefan, Kunz, Patrik, van Loo, Geert, Coenen, Volker Arnd, Reinacher, Peter Christoph, Michel, Anna, Sure, Ulrich, Gold, Ralf, Grün, Dominic, Priller, Josef, Stadelmann, Christine, Prinz, Marco

“…Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central…”
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De Novo Expression of Dopamine D2 Receptors on Microglia after Stroke by Huck, Jojanneke HJ, Freyer, Dorette, Böttcher, Chotima, Mladinov, Mihovil, Muselmann-Genschow, Claudia, Thielke, Mareike, Gladow, Nadine, Bloomquist, Dana, Mergenthaler, Philipp, Priller, Josef

“…Dopamine is the predominant catecholamine in the brain and functions as a neurotransmitter. Dopamine is also a potent immune modulator. In this study, we have…”
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Diverse modulatory effects of bibenzyls from Dendrobium species on human immune cell responses under inflammatory conditions by Kongkatitham, Virunh, Dehlinger, Adeline, Chaotham, Chatchai, Likhitwitayawuid, Kittisak, Böttcher, Chotima, Sritularak, Boonchoo

“…Dendrobium plants are widely used in traditional Chinese medicine. Their secondary metabolites such as bibenzyls and phenanthrenes show various pharmacological…”
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Mapping the origin and fate of myeloid cells in distinct compartments of the eye by single‐cell profiling by Wieghofer, Peter, Hagemeyer, Nora, Sankowski, Roman, Schlecht, Anja, Staszewski, Ori, Amann, Lukas, Gruber, Markus, Koch, Jana, Hausmann, Annika, Zhang, Peipei, Boneva, Stefaniya, Masuda, Takahiro, Hilgendorf, Ingo, Goldmann, Tobias, Böttcher, Chotima, Priller, Josef, Rossi, Fabio MV, Lange, Clemens, Prinz, Marco

“…Similar to the brain, the eye is considered an immune‐privileged organ where tissue‐resident macrophages provide the major immune cell constituents. However,…”
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Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease by Mildner, Alexander, Schlevogt, Bernhard, Kierdorf, Katrin, Böttcher, Chotima, Erny, Daniel, Kummer, Markus P, Quinn, Michael, Brück, Wolfgang, Bechmann, Ingo, Heneka, Michael T, Priller, Josef, Prinz, Marco

“…Mononuclear phagocytes are important modulators of Alzheimer's disease (AD), but the specific functions of resident microglia, bone marrow-derived mononuclear…”
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Human small intestinal infection by SARS-CoV-2 is characterized by a mucosal infiltration with activated CD8+ T cells by Lehmann, Malte, Allers, Kristina, Heldt, Claudia, Meinhardt, Jenny, Schmidt, Franziska, Rodriguez-Sillke, Yasmina, Kunkel, Désirée, Schumann, Michael, Böttcher, Chotima, Stahl-Hennig, Christiane, Elezkurtaj, Sefer, Bojarski, Christian, Radbruch, Helena, Corman, Victor M., Schneider, Thomas, Loddenkemper, Christoph, Moos, Verena, Weidinger, Carl, Kühl, Anja A., Siegmund, Britta

“…The SARS-CoV-2 pandemic has so far claimed over three and a half million lives worldwide. Though the SARS-CoV-2 mediated disease COVID-19 has first been…”
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Immunomodulatory Effects of New Phenanthrene Derivatives from Dendrobium crumenatum by Kongkatitham, Virunh, Dehlinger, Adeline, Wang, Meng, Poldorn, Preeyaporn, Weidinger, Carl, Letizia, Marilena, Chaotham, Chatchai, Otto, Carolin, Ruprecht, Klemens, Paul, Friedemann, Rungrotmongkol, Thanyada, Likhitwitayawuid, Kittisak, Böttcher, Chotima, Sritularak, Boonchoo

“…Three new phenanthrene derivatives (1, 2, 4), one new fluorenone (3), and four known compounds (5–8) were isolated from the ethyl acetate extract of Dendrobium…”
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The use and limitations of single‐cell mass cytometry for studying human microglia function by Fernández‐Zapata, Camila, Leman, Julia K. H., Priller, Josef, Böttcher, Chotima

“…Microglia, the resident innate immune cells of the central nervous system (CNS), play an important role in brain development and homoeostasis, as well as in…”
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Immune modulatory effect of a novel 4,5-dihydroxy-3,3´,4´-trimethoxybibenzyl from Dendrobium lindleyi by Khoonrit, Pichayatri, Mirdogan, Alp, Dehlinger, Adeline, Mekboonsonglarp, Wanwimon, Likhitwitayawuid, Kittisak, Priller, Josef, Böttcher, Chotima, Sritularak, Boonchoo

“…Dendrobium bibenzyls and phenanthrenes such as chrysotoxine, cypripedin, gigantol and moscatilin have been reported to show promising inhibitory effects on…”
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Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas by Friedrich, Mirco, Sankowski, Roman, Bunse, Lukas, Kilian, Michael, Green, Edward, Ramallo Guevara, Carina, Pusch, Stefan, Poschet, Gernot, Sanghvi, Khwab, Hahn, Markus, Bunse, Theresa, Münch, Philipp, Gegner, Hagen M, Sonner, Jana K, von Landenberg, Anna, Cichon, Frederik, Aslan, Katrin, Trobisch, Tim, Schirmer, Lucas, Abu-Sammour, Denis, Kessler, Tobias, Ratliff, Miriam, Schrimpf, Daniel, Sahm, Felix, Hopf, Carsten, Heiland, Dieter H, Schnell, Oliver, Beck, Jürgen, Böttcher, Chotima, Fernandez-Zapata, Camila, Priller, Josef, Heiland, Sabine, Gutcher, Ilona, Quintana, Francisco J, von Deimling, Andreas, Wick, Wolfgang, Prinz, Marco, Platten, Michael

“…The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are poorly understood. Here we define myeloid cellular states in gliomas by…”
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Single-cell mass cytometry of microglia in major depressive disorder reveals a non-inflammatory phenotype with increased homeostatic marker expression by Böttcher, Chotima, Fernández-Zapata, Camila, Snijders, Gijsje J. L., Schlickeiser, Stephan, Sneeboer, Marjolein A. M., Kunkel, Desiree, De Witte, Lot D., Priller, Josef

“…Stress-induced disturbances of brain homeostasis and neuroinflammation have been implicated in the pathophysiology of mood disorders. In major depressive…”
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Cholinergic Pathway Suppresses Pulmonary Innate Immunity Facilitating Pneumonia After Stroke by Engel, Odilo, Akyüz, Levent, da Costa Goncalves, Andrey C, Winek, Katarzyna, Dames, Claudia, Thielke, Mareike, Herold, Susanne, Böttcher, Chotima, Priller, Josef, Volk, Hans Dieter, Dirnagl, Ulrich, Meisel, Christian, Meisel, Andreas

“…Temporary immunosuppression has been identified as a major risk factor for the development of pneumonia after acute central nervous system injury. Although…”
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1,2-13C2-Glucose Tracing Approach to Assess Metabolic Alterations of Human Monocytes under Neuroinflammatory Conditions by Giacomello, Ginevra, Otto, Carolin, Priller, Josef, Ruprecht, Klemens, Böttcher, Chotima, Parr, Maria Kristina

“…Neuroinflammation is one of the common features in most neurological diseases including multiple sclerosis (MScl) and neurodegenerative diseases such as…”
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Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease by Fernández Zapata, Camila, Giacomello, Ginevra, Spruth, Eike J., Middeldorp, Jinte, Gallaccio, Gerardina, Dehlinger, Adeline, Dames, Claudia, Leman, Julia K. H., van Dijk, Roland E., Meisel, Andreas, Schlickeiser, Stephan, Kunkel, Desiree, Hol, Elly M., Paul, Friedemann, Parr, Maria Kristina, Priller, Josef, Böttcher, Chotima

“…Myeloid cells are suggested as an important player in Alzheimer´s disease (AD). However, its continuum of phenotypic and functional changes across different…”
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Isotopic tracing of glucose metabolites in human monocytes to assess changes in inflammatory conditions by Giacomello, Ginevra, Böttcher, Chotima, Parr, Maria Kristina

“…Differences in metabolic profiles can link to functional changes of immune cells in disease conditions. Here, we detail a protocol for the detection and…”
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Associations of myeloid cells with cellular and humoral responses following vaccinations in patients with neuroimmunological diseases by Wang, Meng, Dehlinger, Adeline, Zapata, Camila Fernández, Golan, Maya, Gallaccio, Gerardina, Sander, Leif E., Schlickeiser, Stephan, Kunkel, Desiree, Schmitz-Hübsch, Tanja, Sawitzki, Birgit, Karni, Arnon, Braun, Julian, Loyal, Lucie, Thiel, Andreas, Bellmann-Strobl, Judith, Paul, Friedemann, Meyer-Arndt, Lil, Böttcher, Chotima

“…Disease-modifying therapies (DMTs) are widely used in neuroimmunological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder…”
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Store‐operated calcium entry controls innate and adaptive immune cell function in inflammatory bowel disease by Letizia, Marilena, Wang, Yin‐Hu, Kaufmann, Ulrike, Gerbeth, Lorenz, Sand, Annegret, Brunkhorst, Max, Weidner, Patrick, Ziegler, Jörn Felix, Böttcher, Chotima, Schlickeiser, Stephan, Fernández, Camila, Yamashita, Megumi, Stauderman, Kenneth, Sun, Katherine, Kunkel, Désirée, Prakriya, Murali, Sanders, Ashley, Siegmund, Britta, Feske, Stefan, Weidinger, Carl

“…Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell…”
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