Search Results - "Bottani, Michela"
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Perspectives on miRNAs as Epigenetic Markers in Osteoporosis and Bone Fracture Risk: A Step Forward in Personalized Diagnosis
Published in Frontiers in genetics (30-10-2019)“…Aging is associated with an increased incidence of age-related bone diseases. Current diagnostics (e.g., conventional radiology, biochemical markers), because…”
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The Clinical Potential of Circulating miRNAs as Biomarkers: Present and Future Applications for Diagnosis and Prognosis of Age-Associated Bone Diseases
Published in Biomolecules (Basel, Switzerland) (11-04-2020)“…Osteoporosis, related fracture/fragility, and osteoarthritis are age-related pathologies that, over recent years, have seen increasing incidence and prevalence…”
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Morphofunctional properties of a differentiated Caco2/HT-29 co-culture as an in vitro model of human intestinal epithelium
Published in Bioscience reports (27-04-2018)“…An intestinal 70/30 Caco2/HT-29 co-culture was set up starting from the parental populations of differentiated cells to mimic the human intestinal epithelium…”
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In vitro antioxidant properties of digests of hydrolyzed casein and caseinophosphopeptide preparations in cell models of human intestine and osteoblasts
Published in Journal of functional foods (01-01-2020)“…[Display omitted] •In vitro casein and caseinophosphopeptide digests were assessed as antioxidants.•Digests were administered to in vitro cell model of human…”
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Chemical and nutritional properties of white bread leavened by lactic acid bacteria
Published in Journal of functional foods (01-06-2018)“…Four LAB strains belonging to the Lactobacillus and Leuconostoc genera were investigated in experimental bread-making in comparison with Saccharomyces…”
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Betaine promotes cell differentiation of human osteoblasts in primary culture
Published in Journal of translational medicine (07-06-2017)“…Betaine (BET), a component of many foods, is an essential osmolyte and a source of methyl groups; it also shows an antioxidant activity. Moreover, BET…”
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L-Carnitine activates calcium signaling in human osteoblasts
Published in Journal of functional foods (01-08-2018)“…[Display omitted] •L-C induces calcium signaling in human osteoblasts.•L-C induces calcium entry from plasma membrane depolarizing channels.•L-C induces a…”
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Gastrointestinal In Vitro Digests of Infant Biscuits Formulated with Bovine Milk Proteins Positively Affect In Vitro Differentiation of Human Osteoblast-Like Cells
Published in Foods (21-10-2020)“…Infant biscuits (IBs) are part of complementary feeding from weaning up to the age of five years. They normally contain bovine milk proteins, which can…”
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Circulating miRNAs as Diagnostic and Prognostic Biomarkers in Common Solid Tumors: Focus on Lung, Breast, Prostate Cancers, and Osteosarcoma
Published in Journal of clinical medicine (11-10-2019)“…An early cancer diagnosis is essential to treat and manage patients, but it is difficult to achieve this goal due to the still too low specificity and…”
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Bioactive compounds and antioxidant properties of pseudocereals-enriched water biscuits and their in vitro digestates
Published in Food chemistry (01-02-2018)“…•Water biscuits were prepared from wheat, einkorn and einkorn-pseudocereals flours.•Antioxidants differed among formulations before and after in vitro…”
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Excess of nutrient-induced morphofunctional adaptation and inflammation degree in a Caco2/HT-29 in vitro intestinal co-culture
Published in Nutrition (Burbank, Los Angeles County, Calif.) (01-02-2019)“…•Nutrient excess increases in vitro mucus production and reduces tight junctions.•Nutrient excess increases the specific activity of intestinal…”
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Bovine whey peptides transit the intestinal barrier to reduce oxidative stress in muscle cells
Published in Food chemistry (01-08-2019)“…•Whey peptides identified after simulated gastrointestinal digestion.•Whey peptides transported across Caco-2/HT-29 intestinal barrier.•ALPM, GDLE, VGIN and…”
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European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum thyroid biomarkers based on weekly samplings from 91 healthy participants
Published in Clinical chemistry and laboratory medicine (28-03-2022)“…Thyroid biomarkers are fundamental for the diagnosis of thyroid disorders and for the monitoring and treatment of patients with these diseases. The knowledge…”
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L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells
Published in BioMed research international (01-01-2019)“…Bone fragility and associated fracture risk are major problems in aging. Oxidative stress and mitochondrial dysfunction play a key role in the development of…”
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In vitro and in vivo evaluation of Bombesin-MMAE conjugates for targeted tumour therapy
Published in European journal of medicinal chemistry (05-11-2024)“…Targeted tumour therapy has proved to be an efficient alternative to overcome the limitations of conventional chemotherapy. The upregulation of the bombesin…”
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Gastrointestinal digestates of Grana Padano and Trentingrana cheeses promote intestinal calcium uptake and extracellular bone matrix formation in vitro
Published in Food research international (01-11-2016)“…In the present work, Grana Padano (GP) and Trentingrana (TN) cheeses at different ripening time were in vitro digested. To study calcium uptake and…”
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European Biological Variation Study (EuBIVAS): within- and between-subject biological variation estimates for serum biointact parathyroid hormone based on weekly samplings from 91 healthy participants
Published in Annals of translational medicine (01-07-2020)“…The European Biological Variation Study (EuBIVAS) was created by the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) Working Group on…”
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