Search Results - "Botta, Davide"

Inhibition of the NAD salvage pathway in schistosomes impairs metabolism, reproduction, and parasite survival by Schultz, Michael D, Dadali, Tulin, Jacques, Sylvain A, Muller-Steffner, Hélène, Foote, Jeremy B, Sorci, Leonardo, Kellenberger, Esther, Botta, Davide, Lund, Frances E

“…NAD, a key co-enzyme required for cell metabolism, is synthesized via two pathways in most organisms. Since schistosomes apparently lack enzymes required for…”
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CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven and TRPM2-dependent mechanism by García-Rodríguez, Sonia, Rosal-Vela, Antonio, Botta, Davide, Cumba Garcia, Luz M., Zumaquero, Esther, Prados-Maniviesa, Verónica, Cerezo-Wallis, Daniela, Lo Buono, Nicola, Robles-Guirado, José-Ángel, Guerrero, Salvador, González-Paredes, Elena, Andrés-León, Eduardo, Corbí, Ángel, Mack, Matthias, Koch-Nolte, Friedrich, Merino, Ramón, Zubiaur, Mercedes, Lund, Frances E., Sancho, Jaime

“…In this study, we investigated the role of CD38 in a pristane-induced murine model of lupus. CD38-deficient ( Cd38 −/− ) but not ART2-deficient ( Art2 −/− )…”
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A single intranasal administration of AdCOVID protects against SARS-CoV-2 infection in the upper and lower respiratory tracts by Schultz, Michael D., Suschak, John J., Botta, Davide, Silva-Sanchez, Aaron, King, R. Glenn, Detchemendy, Thomas W., Meshram, Chetan D., Foote, Jeremy B., Zhou, Fen, Tipper, Jennifer L., Zhang, Jianfeng, Harrod, Kevin S., Leal, Sixto M., Randall, Troy D., Roberts, M. Scot, Georges, Bertrand, Lund, Frances E.

“…The coronavirus disease 2019 (COVID-19) pandemic has illustrated the critical need for effective prophylactic vaccination to prevent the spread of severe acute…”
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IFNγ induces epigenetic programming of human T-bethi B cells and promotes TLR7/8 and IL-21 induced differentiation by Zumaquero, Esther, Stone, Sara L, Scharer, Christopher D, Jenks, Scott A, Nellore, Anoma, Mousseau, Betty, Rosal-Vela, Antonio, Botta, Davide, Bradley, John E, Wojciechowski, Wojciech, Ptacek, Travis, Danila, Maria I, Edberg, Jeffrey C, Bridges, S Louis, Kimberly, Robert P, Chatham, W Winn, Schoeb, Trenton R, Rosenberg, Alexander F, Boss, Jeremy M, Sanz, Ignacio, Lund, Frances E

“…Although B cells expressing the IFNγR or the IFNγ-inducible transcription factor T-bet promote autoimmunity in Systemic Lupus Erythematosus (SLE)-prone mouse…”
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GABA and Combined GABA with GAD65-Alum Treatment Alters Th1 Cytokine Responses of PBMCs from Children with Recent-Onset Type 1 Diabetes by Heath, Katie E, Feduska, Joseph M, Taylor, Jared P, Houp, Julie A, Botta, Davide, Lund, Frances E, Mick, Gail J, McGwin, Jr, Gerald, McCormick, Kenneth L, Tse, Hubert M

“…Type 1 diabetes (T1D) is an autoimmune disease culminating in the destruction of insulin-producing pancreatic cells. There is a need for the development of…”
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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection by Botta, Davide, Fuller, Michael J, Marquez-Lago, Tatiana T, Bachus, Holly, Bradley, John E, Weinmann, Amy S, Zajac, Allan J, Randall, Troy D, Lund, Frances E, León, Beatriz, Ballesteros-Tato, André

“…Humoral immunity is necessary for controlling viral infection. Ballesteros-Tato and colleagues show that development of follicular regulatory T cells is…”
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Priming of Long-Lived Memory CD8+ T cell Responses in the Spleen During Influenza Virus Infection by Jenkins, Meagan M, Bachus, Holly, Botta, Davide, Schultz, Michael, Rosenberg, Alexander, León, Beatriz, Ballesteros-Tato, André

“…Abstract CD8+ T cell responses to influenza virus infection are canonically known to be activated solely in the lung draining, mediastinal lymph node (mLN)…”
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Priming by lung-mDCs in the spleen initiates CD8+ T cell responses during influenza infection by Jenkins, Meagan M, Bachus, Holly, Botta, Davide, Leon-Ruiz, Beatriz, Ballesteros-Tato, Andre

“…Abstract Initiation of CD8+ T cell responses to influenza virus requires the trafficking of activated lung-migratory dendritic cells (mDCs) from the lung into…”
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The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expression by Taylor, Jared P, Blum, Samuel I, Graffeo, Hollis C, Shang, Qiao, Qiu, Shihong, Green, Todd J, Botta, Davide, Lund, Frances E, Tse, Hubert M

“…Type 1 diabetes (T1D) is a chronic autoimmune disease that is caused by a combination of genetic and environmental risk factors. In this study, we sought to…”
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The NAD glycohydrolase CD38 regulates macrophage effector function and defense against Listeria monocytogenes . (INC7P.409) by Botta, Davide, Rivero-Nava, Laura, Lund, Frances

“…Abstract CD38, an ecto-enzyme with ADP-ribosyl cyclase activity, is expressed on myeloid cells and has been shown to be a regulator of innate immunity and…”
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Abstract P1107: Acute Psychosocial Stress Increases Circulating Inflammatory Mediators in the Humanized Sickle Cell Mouse Model by Molina, Patrick, Fox, Brandon, Sedaka, Randee, Becker, Bryan, Kasztan, Malgorzata, Botta, Davide, Allan, J. Miller, Pollock, David, Pollock, Jennifer

“…Abstract only Vaso-occlusive crisis often occurs in sickle cell disease (SCD). Since psychosocial stress leads to impaired vascular function and inflammation,…”
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Abstract P063: Pressor Response To Acute Stress Is Regulated By Histamine In Humanized Sickle Cell Mice by Molina, Patrick A, Fox, Brandon M, Sedaka, Randee, Botta, Davide, Becker, Bryan, Allan, John, Kasztan, Malgorzata, Pollock, David M, Pollock, Jennifer

“…Abstract only Acute psychosocial stress has been linked to the onset of vaso-occlusive pain crises in patients with sickle cell disease (SCD), however…”
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Endothelial histone deacetylase 1 activity impairs kidney microvascular NO signaling in rats fed a high‐salt diet by Dunaway, Luke S., Cook, Anthony K., Kellum, Cailin E., Edell, Claudia, Botta, Davide, Molina, Patrick A., Sedaka, Randee S., d'Uscio, Livius V., Katusic, Zvonimir S., Pollock, David M., Inscho, Edward W., Pollock, Jennifer S.

“…Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in kidney microvascular endothelial cells through a histone deacetylase 1…”
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Duration of antigen presentation to influenza-specific CD8+ T cells regulates the development of tissue resident memory populations by Fuller, Michael John, Botta, Davide, Schultz, Michael D., Bachus, Holly, Ballesteros-Tato, Andre

“…Abstract Some memory CD8+ T cells are programmed during the contraction phase of the primary response to have robust secondary responsiveness, a phenomenon…”
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Identification of a Regulatory Segment of Poly(ADP-ribose) Glycohydrolase by Botta, Davide, Jacobson, Myron K

“…Coordinate regulation of PARP-1 and -2 and PARG is required for cellular responses to genotoxic stress. While PARP-1 and -2 are regulated by DNA breaks and…”
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Renal T H 17 cells are Elevated in Humanized Sickle Cell Mice by Molina, Patrick Axel, Fox, Brandon M., De Miguel, Carmen, McMonigle, Ryan J., Botta, Davide, Huang, Fengyuan, Kasztan, Malgorzata, Pollock, David M., Pollock, Jennifer S.

“…Abstract only Sickle cell nephropathy (SCN) is a major complication of sickle cell disease (SCD). However, it is not fully understood what role immune cells…”
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Renal TH17 cells are Elevated in Humanized Sickle Cell Mice by Molina, Patrick Axel, Fox, Brandon M., De Miguel, Carmen, McMonigle, Ryan J., Botta, Davide, Huang, Fengyuan, Kasztan, Malgorzata, Pollock, David M., Pollock, Jennifer S.

“…Sickle cell nephropathy (SCN) is a major complication of sickle cell disease (SCD). However, it is not fully understood what role immune cells play in SCN…”
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Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by Interleukin-2 (IL-2) during influenza infection by Ballesteros-Tato, Andre, Botta, Davide, Fuller, Michael J, Bachus, Holly, Bradley, John E, Zajac, Allan J, Randall, Troy D, Lund, Frances E, Ruiz, Beatriz León

“…Abstract IL-2 promotes FoxP3+ regulatory T (Treg) cell responses, but inhibits the differentiation of T follicular helper (Tfh) cells. However, it is not clear…”
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Deficiency in transient receptor potential melastatin 2 impairs alveolar macrophage activation and protects mice against endotoxin-induced lung inflammation and injury (INC5P.333) by Botta, Davide, Mudunuru, Uma, Southworth, Kristen, Simpler, Thomas, Bradley, John, Randall, Troy, Stevenson, Christopher, Lund, Frances

“…Abstract Cellular responses to reactive oxygen species (ROS) are induced by many receptors including the non-selective cation channel TRPM2 that promotes…”
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TMIC-12. TUMOR EDGE-DESTINED CELLS IN GBM CELLS IN A CELL-INTRINSIC MECHANISM by Yamashita, Daisuke, Minata, Mutsuko, Yu, Hai, Zhang, Soujun, Li, Chaoxi, Flanary, Victoria, Ghosh, Sadashib, Lee, Yeri, Cho, Heejin, Botta, Davide, Guo, Xiaoxian, Ozaki, Saya, Yamaguchi, Shinobu, Komarova, Svetlana, Bastola, Soniya, Crossman, David, Nabors, Louis, Markert, James, Gu, Zhenglong, Skolnick, Jeffrey, Zamboni, Nicola, Lund, Frances, Nam, Do-Hyun, Nakano, Ichiro

“…Abstract The highly infiltrative nature of glioblastoma (GBM) underscores limited response to current therapies and subsequent unfavorable clinical outcome…”
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