Search Results - "Botta, Cirino"

AURKA targeting: a NEAT approach to halt myeloma by Solimando, Antonio Giovanni, Botta, Cirino

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Iron Metabolism in the Tumor Microenvironment-Implications for Anti-Cancer Immune Response by Sacco, Alessandro, Battaglia, Anna Martina, Botta, Cirino, Aversa, Ilenia, Mancuso, Serafina, Costanzo, Francesco, Biamonte, Flavia

“…New insights into the field of iron metabolism within the tumor microenvironment have been uncovered in recent years. Iron promotes the production of reactive…”
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A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells by Gullà, Annamaria, Di Martino, Maria Teresa, Gallo Cantafio, Maria Eugenia, Morelli, Eugenio, Amodio, Nicola, Botta, Cirino, Pitari, Maria Rita, Lio, Santo Giovanni, Britti, Domenico, Stamato, Maria Angelica, Hideshima, Teru, Munshi, Nikhil C, Anderson, Kenneth C, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in…”
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miR-29b negatively regulates human osteoclastic cell differentiation and function: Implications for the treatment of multiple myeloma-related bone disease by Rossi, Marco, Pitari, Maria Rita, Amodio, Nicola, Di Martino, Maria Teresa, Conforti, Francesco, Leone, Emanuela, Botta, Cirino, Paolino, Francesco Maria, Del Giudice, Teresa, Iuliano, Eleonora, Caraglia, Michele, Ferrarini, Manlio, Giordano, Antonio, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…Skeletal homeostasis relies upon a fine tuning of osteoclast (OCL)‐mediated bone resorption and osteoblast (OBL)‐dependent bone formation. This balance is…”
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miR-21 antagonism abrogates Th17 tumor promoting functions in multiple myeloma by Rossi, Marco, Altomare, Emanuela, Botta, Cirino, Gallo Cantafio, Maria Eugenia, Sarvide, Sarai, Caracciolo, Daniele, Riillo, Caterina, Gaspari, Marco, Taverna, Domenico, Conforti, Francesco, Critelli, Paola, Bertucci, Bernardo, Iannone, Michelangelo, Polerà, Nicoletta, Scumaci, Domenica, Arbitrio, Mariamena, Amodio, Nicola, Di Martino, Maria Teresa, Paiva, Bruno, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…Multiple myeloma (MM) is tightly dependent on inflammatory bone marrow microenvironment. IL-17 producing CD4+ T cells (Th17) sustain MM cells growth and…”
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Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination by Garcés, Juan-Jose, Simicek, Michal, Vicari, Marco, Brozova, Lucie, Burgos, Leire, Bezdekova, Renata, Alignani, Diego, Calasanz, Maria-Jose, Growkova, Katerina, Goicoechea, Ibai, Agirre, Xabier, Pour, Ludek, Prosper, Felipe, Rios, Rafael, Martinez-Lopez, Joaquin, Millacoy, Pamela, Palomera, Luis, Del Orbe, Rafael, Perez-Montaña, Albert, Garate, Sonia, Blanco, Laura, Lasa, Marta, Maiso, Patricia, Flores-Montero, Juan, Sanoja-Flores, Luzalba, Chyra, Zuzana, Vdovin, Alexander, Sevcikova, Tereza, Jelinek, Tomas, Botta, Cirino, El Omri, Halima, Keats, Jonathan, Orfao, Alberto, Hajek, Roman, San-Miguel, Jesus F., Paiva, Bruno

“…The reason why a few myeloma cells egress from the bone marrow (BM) into peripheral blood (PB) remains unknown. Here, we investigated molecular hallmarks of…”
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B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma by Mohammadnezhad, Leila, Shekarkar Azgomi, Mojtaba, La Manna, Marco Pio, Guggino, Giuliana, Botta, Cirino, Dieli, Francesco, Caccamo, Nadia

“…Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL)…”
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Combined lymphocyte/monocyte count, D-dimer and iron status predict COVID-19 course and outcome in a long-term care facility by Biamonte, Flavia, Botta, Cirino, Mazzitelli, Maria, Rotundo, Salvatore, Trecarichi, Enrico Maria, Foti, Daniela, Torti, Carlo, Viglietto, Giuseppe, Torella, Daniele, Costanzo, Francesco

“…The Sars-CoV-2 can cause severe pneumonia with multiorgan disease; thus, the identification of clinical and laboratory predictors of the progression towards…”
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Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts by Pitari, Maria Rita, Rossi, Marco, Amodio, Nicola, Botta, Cirino, Morelli, Eugenio, Federico, Cinzia, Gullà, Annamaria, Caracciolo, Daniele, Di Martino, Maria Teresa, Arbitrio, Mariamena, Giordano, Antonio, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…miR-21 is an oncogenic microRNA (miRNA) with an emerging role as therapeutic target in human malignancies, including multiple myeloma (MM). Here we…”
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Mechanisms of Immune Evasion in Multiple Myeloma: Open Questions and Therapeutic Opportunities by Botta, Cirino, Mendicino, Francesco, Martino, Enrica Antonia, Vigna, Ernesto, Ronchetti, Domenica, Correale, Pierpaolo, Morabito, Fortunato, Neri, Antonino, Gentile, Massimo

“…Multiple myeloma (MM) is the second most common hematologic malignancy, characterized by a multi-step evolutionary path, which starts with an early…”
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Impact of daratumumab/bortezomib/thalidomide and dexamethasone induction therapy on chemo-free stem cell mobilization in transplant eligible newly diagnosed multiple myeloma: a multicentre real-world experience by Porrazzo, Marika, Moscato, Tiziana, Sapienza, Giuseppe, Accardi, Fabrizio, Patti, Caterina, Cangialosi, Clotilde, Costanza, Carmelo, Bono, Roberto, Tringali, Stefania, Rotolo, Cristina, Gigliotta, Emilia, Rizzuto, Andrea, Ingrascè, Manuela Giuseppa, Butera, Giulia, Di Noto, Laura, Santoro, Alessandra, Marfia, Anna, Botta, Cirino, Siragusa, Sergio, Martino, Massimo, Castagna, Luca

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Molecular-Biology-Driven Frontline Treatment for Chronic Lymphocytic Leukemia: A Network Meta-Analysis of Randomized Clinical Trials by Rizzuto, Andrea, Pirrera, Angelo, Gigliotta, Emilia, Mancuso, Salvatrice, Vullo, Candida, Camarda, Giulia Maria, Rotolo, Cristina, Roppolo, Arianna, Spoto, Corinne, Gentile, Massimo, Botta, Cirino, Siragusa, Sergio

“…The treatment of chronic lymphocytic leukemia (CLL) currently relies on the use of chemo-immunotherapy, Bruton's tyrosine kinase inhibitors, or BCL2 inhibitors…”
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Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome by Plano, Federica, Gigliotta, Emilia, Corsale, Anna Maria, Azgomi, Mojtaba Shekarkar, Santonocito, Carlotta, Ingrascì, Manuela, Di Carlo, Laura, Augello, Antonino Elia, Speciale, Maria, Vullo, Candida, Rotolo, Cristina, Camarda, Giulia Maria, Caccamo, Nadia, Meraviglia, Serena, Dieli, Francesco, Siragusa, Sergio, Botta, Cirino

“…Multiple myeloma (MM) is a hematologic malignancy with a multistep evolutionary pattern, in which the pro-inflammatory and immunosuppressive microenvironment…”
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Myositis/Myasthenia after Pembrolizumab in a Bladder Cancer Patient with an Autoimmunity-Associated HLA: Immune–Biological Evaluation and Case Report by Botta, Cirino, Agostino, Rita Maria, Dattola, Vincenzo, Cianci, Vittoria, Calandruccio, Natale Daniele, Bianco, Giovanna, Mafodda, Antonino, Maisano, Roberto, Iuliano, Eleonora, Orizzonte, Giovanna, Mazzacuva, Domenico, Falzea, Antonia Consuelo, Saladino, Rita Emilena, Giannicola, Rocco, Restifo, Giorgio, Aguglia, Umberto, Caraglia, Michele, Correale, Pierpaolo

“…Pembrolizumab (mAb to PD-1) has been recently approved for the therapy of pretreated urothelial cancer. Despite the efficacy, it is often accompanied by…”
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Systemic inflammatory status at baseline predicts bevacizumab benefit in advanced non-small cell lung cancer patients by Botta, Cirino, Barbieri, Vito, Ciliberto, Domenico, Rossi, Antonio, Rocco, Danilo, Addeo, Raffaele, Staropoli, Nicoletta, Pastina, Pierpaolo, Marvaso, Giulia, Martellucci, Ignazio, Guglielmo, Annamaria, Pirtoli, Luigi, Sperlongano, Pasquale, Gridelli, Cesare, Caraglia, Michele, Tassone, Pierfrancesco, Tagliaferri, Pierosandro, Correale, Pierpaolo

“…Bevacizumab is a humanized anti-VEGF monoclonal antibody able to produce clinical benefit in advanced non-squamous non-small-cell lung cancer (NSCLC) patients…”
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Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing by Vicario, Nunzio, Spitale, Federica M., Tibullo, Daniele, Giallongo, Cesarina, Amorini, Angela M., Scandura, Grazia, Spoto, Graziana, Saab, Miriam W., D’Aprile, Simona, Alberghina, Cristiana, Mangione, Renata, Bernstock, Joshua D., Botta, Cirino, Gulisano, Massimo, Buratti, Emanuele, Leanza, Giampiero, Zorec, Robert, Vecchio, Michele, Di Rosa, Michelino, Li Volti, Giovanni, Lazzarino, Giuseppe, Parenti, Rosalba, Gulino, Rosario

“…Motoneuronal loss is the main feature of amyotrophic lateral sclerosis, although pathogenesis is extremely complex involving both neural and muscle cells. In…”
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Treatment of Lenalidomide Exposed or Refractory Multiple Myeloma: Network Meta-Analysis of Lenalidomide-Sparing Regimens by Botta, Cirino, Martino, Enrica Antonia, Conticello, Concetta, Mendicino, Francesco, Vigna, Ernesto, Romano, Alessandra, Palumbo, Giuseppe Antonio, Cerchione, Claudio, Martinelli, Giovanni, Morabito, Fortunato, Di Raimondo, Francesco, Gentile, Massimo

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Immunomodulatory Activity of MicroRNAs: Potential Implications for Multiple Myeloma Treatment by Botta, Cirino, Cuce, Maria, Caracciolo, Daniele, Fiorillo, Lucia, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…Multiple myeloma (MM) is an incurable plasma cell neoplasm accounting for about 10% of all hematologic malignancies. Recently, emerging evidence is disclosing…”
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COVID-19: High-JAKing of the Inflammatory "Flight" by Ruxolitinib to Avoid the Cytokine Storm by Botta, Cirino, Indrieri, Alessia, Garofalo, Eugenio, Biamonte, Flavia, Bruni, Andrea, Pasqua, Pino, Cesario, Francesco, Costanzo, Francesco Saverio, Longhini, Federico, Mendicino, Francesco

“…Since SARS-CoV-2 outbreak in December 2019, world health-system has been severely impacted with increased hospitalization, Intensive-Care-Unit (ICU) access and…”
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Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients by Botta, Cirino, Ciliberto, Domenico, Rossi, Marco, Staropoli, Nicoletta, Cucè, Maria, Galeano, Teresa, Tagliaferri, Pierosandro, Tassone, Pierfrancesco

“…Despite major therapeutic advancements, multiple myeloma (MM) is still incurable and relapsed/refractory multiple myeloma (RRMM) remains a challenge; the…”
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