Search Results - "Botrugno, A"

ATR addiction in multiple myeloma: synthetic lethal approaches exploiting established therapies by Botrugno, Oronza A, Bianchessi, Silvia, Zambroni, Desirée, Frenquelli, Michela, Belloni, Daniela, Bongiovanni, Lucia, Girlanda, Stefania, Di Terlizzi, Simona, Ferrarini, Marina, Ferrero, Elisabetta, Ponzoni, Maurilio, Marcatti, Magda, Tonon, Giovanni

“…Therapeutic strategies designed to tinker with cancer cell DNA damage response have led to the widespread use of PARP inhibitors for BRCA1/2-mutated cancers…”
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Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer by Mercurio, Ciro, dal Zuffo, Roberto, Liontos, Michalis, d'Ario, Giovanni, Hahn, William C, Gorgoulis, Vassilis, Dobreva, Miryana, Minucci, Saverio, Sulli, Gabriele, Montani, Erica, d'Adda di Fagagna, Fabrizio, Matti, Valentina, Gargiulo, Gaetano, Di Micco, Raffaella, Botrugno, Oronza A

“…Different mechanisms have been implicated in the induction of senescence. Two of these mechanisms, the DNA damage response, which induces a replicative…”
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Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases LSD1 and LSD2 by Binda, Claudia, Valente, Sergio, Romanenghi, Mauro, Pilotto, Simona, Cirilli, Roberto, Karytinos, Aristotele, Ciossani, Giuseppe, Botrugno, Oronza A, Forneris, Federico, Tardugno, Maria, Edmondson, Dale E, Minucci, Saverio, Mattevi, Andrea, Mai, Antonello

“…LSD1 and LSD2 histone demethylases are implicated in a number of physiological and pathological processes, ranging from tumorigenesis to herpes virus…”
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Discovery of a Novel Inhibitor of Histone Lysine-Specific Demethylase 1A (KDM1A/LSD1) as Orally Active Antitumor Agent by Vianello, Paola, Botrugno, Oronza A, Cappa, Anna, Dal Zuffo, Roberto, Dessanti, Paola, Mai, Antonello, Marrocco, Biagina, Mattevi, Andrea, Meroni, Giuseppe, Minucci, Saverio, Stazi, Giulia, Thaler, Florian, Trifiró, Paolo, Valente, Sergio, Villa, Manuela, Varasi, Mario, Mercurio, Ciro

“…We report the stereoselective synthesis and biological activity of a novel series of tranylcypromine (TCPA) derivatives (14a–k, 15, 16), potent inhibitors of…”
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Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure–Activity Relationship by Vianello, Paola, Sartori, Luca, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Vultaggio, Stefania, Zagarrí, Elisa, Varasi, Mario, Mercurio, Ciro

“…The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1). KDM1A is overexpressed in several tumor types, thus representing…”
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Thieno[3,2‑b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration by Sartori, Luca, Mercurio, Ciro, Amigoni, Federica, Cappa, Anna, Fagá, Giovanni, Fattori, Raimondo, Legnaghi, Elena, Ciossani, Giuseppe, Mattevi, Andrea, Meroni, Giuseppe, Moretti, Loris, Cecatiello, Valentina, Pasqualato, Sebastiano, Romussi, Alessia, Thaler, Florian, Trifiró, Paolo, Villa, Manuela, Vultaggio, Stefania, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Zagarrí, Elisa, Carettoni, Daniele, Iuzzolino, Lucia, Varasi, Mario, Vianello, Paola

“…Lysine specific demethylase 1 KDM1A (LSD1) regulates histone methylation and it is increasingly recognized as a potential therapeutic target in oncology. We…”
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Tranylcypromine‐Based LSD1 Inhibitors: Structure‐Activity Relationships, Antiproliferative Effects in Leukemia, and Gene Target Modulation by Fioravanti, Rossella, Romanelli, Annalisa, Mautone, Nicola, Di Bello, Elisabetta, Rovere, Annarita, Corinti, Davide, Zwergel, Clemens, Valente, Sergio, Rotili, Dante, Botrugno, Oronza A., Dessanti, Paola, Vultaggio, Stefania, Vianello, Paola, Cappa, Anna, Binda, Claudia, Mattevi, Andrea, Minucci, Saverio, Mercurio, Ciro, Varasi, Mario, Mai, Antonello

“…: LSD1 is a lysine demethylase highly involved in initiation and development of cancer. To design highly effective covalent inhibitors, a strategy is to fill…”
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Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: A novel class of irreversible inhibitors of histone demethylase KDM1A by Vianello, Paola, Botrugno, Oronza A., Cappa, Anna, Ciossani, Giuseppe, Dessanti, Paola, Mai, Antonello, Mattevi, Andrea, Meroni, Giuseppe, Minucci, Saverio, Thaler, Florian, Tortorici, Marcello, Trifiró, Paolo, Valente, Sergio, Villa, Manuela, Varasi, Mario, Mercurio, Ciro

“…Histone demethylase KDM1A (also known as LSD1) has become an attractive therapeutic target for the treatment of cancer as well as other disorders such as viral…”
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A Novel RGD-4C-Saporin Conjugate Inhibits Tumor Growth in Mouse Models of Bladder Cancer by Zuppone, Stefania, Assalini, Chiara, Minici, Claudia, Botrugno, Oronza A, Curnis, Flavio, Degano, Massimo, Corti, Angelo, Montorsi, Francesco, Salonia, Andrea, Vago, Riccardo

“…Although toxin may have some advantages compared to chemotherapeutic drugs in cancer therapy, e.g. a potent cytotoxic activity and a reduced risk of…”
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Pure enantiomers of benzoylamino-tranylcypromine: LSD1 inhibition, gene modulation in human leukemia cells and effects on clonogenic potential of murine promyelocytic blasts by Valente, Sergio, Rodriguez, Veronica, Mercurio, Ciro, Vianello, Paola, Saponara, Bruna, Cirilli, Roberto, Ciossani, Giuseppe, Labella, Donatella, Marrocco, Biagina, Monaldi, Daria, Ruoppolo, Giovanni, Tilset, Mats, Botrugno, Oronza A., Dessanti, Paola, Minucci, Saverio, Mattevi, Andrea, Varasi, Mario, Mai, Antonello

“…The pure enantiomers of the N-(2-, 3-, and 4-(2-aminocyclopropyl)phenyl)benzamides hydrochlorides 11a–j were prepared and tested against LSD1 and MAO enzymes…”
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Recruitment of the Histone Methyltransferase SUV39H1 and Its Role in the Oncogenic Properties of the Leukemia-Associated PML-Retinoic Acid Receptor Fusion Protein by Carbone, Roberta, Botrugno, Oronza A., Ronzoni, Simona, Insinga, Alessandra, Di Croce, Luciano, Pelicci, Pier Giuseppe, Minucci, Saverio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I by Schoonjans, Kristina, Annicotte, Jean-Sebastien, Huby, Thierry, Botrugno, Oronza A., Fayard, Elisabeth, Ueda, Yukihiko, Chapman, John, Auwerx, Johan

“…The scavenger receptor class B type I (SR‐BI), which mediates selective cellular cholesterol uptake from high‐density lipoproteins (HDLs), plays a key role in…”
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Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies by Valente, Sergio, Rodriguez, Veronica, Mercurio, Ciro, Vianello, Paola, Saponara, Bruna, Cirilli, Roberto, Ciossani, Giuseppe, Labella, Donatella, Marrocco, Biagina, Ruoppolo, Giovanni, Botrugno, Oronza A, Dessanti, Paola, Minucci, Saverio, Mattevi, Andrea, Varasi, Mario, Mai, Antonello

“…The pure four diastereomers (11a–d) of trans-benzyl (1-((4-(2-aminocyclopropyl)phenyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate hydrochloride 11, previously…”
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The Small Heterodimer Partner Interacts with the Liver X Receptor α and Represses Its Transcriptional Activity by Brendel, Carole, Schoonjans, Kristina, Botrugno, Oronza A, Treuter, Eckardt, Auwerx, Johan

“…The small heterodimer partner SHP (NR0B2) is an unusual nuclear receptor that lacks the typical DNA binding domain common to most nuclear receptors. SHP has…”
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Soft X-ray measurements in magnetic fusion plasma physics by Botrugno, A., Gabellieri, L., Mazon, D., Pacella, D., Romano, A.

“…Soft X-ray diagnostic systems and their successful application in the field of magnetic fusion plasma physics are discussed. Radiation with wavelength in the…”
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Scalable integration of multiomic single-cell data using generative adversarial networks by Giansanti, Valentina, Giannese, Francesca, Botrugno, Oronza A, Gandolfi, Giorgia, Balestrieri, Chiara, Antoniotti, Marco, Tonon, Giovanni, Cittaro, Davide

“…Abstract Motivation Single-cell profiling has become a common practice to investigate the complexity of tissues, organs, and organisms. Recent technological…”
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Peaked density profiles in neon and lithium doped discharges on FTU by Mazzotta, C., Apicella, M.L., Botrugno, A., Gabellieri, L., Marinucci, M., Mazzitelli, G., Pucella, G., Sozzi, C., Tudisco, O.

“…Peaked density profiles are observed in FTU discharges when the recycling condition of the chamber is influenced by the action of the liquid lithium limiter…”
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Genomic Instability and Replicative Stress in Multiple Myeloma: The Final Curtain? by Botrugno, Oronza A, Tonon, Giovanni

“…Multiple Myeloma (MM) is a genetically complex and heterogeneous hematological cancer that remains incurable despite the introduction of novel therapies in the…”
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HDACs link the DNA damage response, processing of double-strand breaks and autophagy by Robert, Thomas, Vanoli, Fabio, Chiolo, Irene, Shubassi, Ghadeer, Bernstein, Kara A., Rothstein, Rodney, Botrugno, Oronza A., Parazzoli, Dario, Oldani, Amanda, Minucci, Saverio, Foiani, Marco

“…Protein acetylation is mediated by histone acetyltransferases (HATs) and deacetylases (HDACs), which influence chromatin dynamics, protein turnover and the DNA…”
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Leveraging the potential of 1.0-mm i.d. columns in UHPLC-HRMS-based untargeted metabolomics by La Gioia, Danila, Salviati, Emanuela, Basilicata, Manuela Giovanna, Felici, Claudia, Botrugno, Oronza A, Tonon, Giovanni, Sommella, Eduardo, Campiglia, Pietro

“…Untargeted metabolomics UHPLC-HRMS workflows typically employ narrowbore 2.1-mm inner diameter (i.d.) columns. However, the wide concentration range of the…”
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