Search Results - "Botling, J"

Fibroblast subsets in non-small cell lung cancer: Associations with survival, mutations, and immune features by Pellinen, Teijo, Paavolainen, Lassi, Martín-Bernabé, Alfonso, Papatella Araujo, Renata, Strell, Carina, Mezheyeuski, Artur, Backman, Max, La Fleur, Linnea, Brück, Oscar, Sjölund, Jonas, Holmberg, Erik, Välimäki, Katja, Brunnström, Hans, Botling, Johan, Moreno-Ruiz, Pablo, Kallioniemi, Olli, Micke, Patrick, Östman, Arne

“…Cancer-associated fibroblasts (CAFs) are molecularly heterogeneous mesenchymal cells that interact with malignant cells and immune cells and confer anti- and…”
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Implementing precision medicine in a regionally organized healthcare system in Sweden by Fioretos, Thoas, Wirta, Valtteri, Cavelier, Lucia, Berglund, Eva, Friedman, Mikaela, Akhras, Michael, Botling, Johan, Ehrencrona, Hans, Engstrand, Lars, Helenius, Gisela, Fagerqvist, Therese, Gisselsson, David, Gruvberger-Saal, Sofia, Gyllensten, Ulf, Heidenblad, Markus, Höglund, Kina, Jacobsson, Bo, Johansson, Maria, Johansson, Åsa, Soller, Maria Johansson, Landström, Maréne, Larsson, Pär, Levin, Lars-Åke, Lindstrand, Anna, Lovmar, Lovisa, Lyander, Anna, Melin, Malin, Nordgren, Ann, Nordmark, Gunnel, Mölling, Paula, Palmqvist, Lars, Palmqvist, Richard, Repsilber, Dirk, Sikora, Per, Stenmark, Bianca, Söderkvist, Peter, Stranneheim, Henrik, Strid, Tobias, Wheelock, Craig E., Wadelius, Mia, Wedell, Anna, Edsjö, Anders, Rosenquist, Richard

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Utilizing CD44v6 and V600EBRAF-mutation for in vitro targeted combination therapy of thyroid carcinomas by Mortensen, A.C.L., Imgenberg-Kreuz, J., Spiegelberg, D., Botling, J., Nestor, M.

“…The aim of this study was to assess the feasibility of targeted therapy of thyroid carcinoma, first exploring potential targets BRAF, EGFR and CD44v6 in…”
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CD99 is a novel prognostic stromal marker in non-small cell lung cancer by Edlund, Karolina, Lindskog, Cecilia, Saito, Akira, Berglund, Anders, Pontén, Fredrik, Göransson-Kultima, Hanna, Isaksson, Anders, Jirström, Karin, Planck, Maria, Johansson, Leif, Lambe, Mats, Holmberg, Lars, Nyberg, Fredrik, Ekman, Simon, Bergqvist, Michael, Landelius, Per, Lamberg, Kristina, Botling, Johan, Östman, Arne, Micke, Patrick

“…The complex interaction between cancer cells and the microenvironment plays an essential role in all stages of tumourigenesis. Despite the significance of this…”
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Targeted resequencing of candidate genes using selector probes by Johansson, H, Isaksson, M, Sörqvist, E. Falk, Roos, F, Stenberg, J, Sjöblom, T, Botling, J, Micke, P, Edlund, K, Fredriksson, S, Kultima, H. Göransson, Ericsson, Olle, Nilsson, Mats

“…Targeted genome enrichment is a powerful tool for making use of the massive throughput of novel DNA-sequencing instruments. We herein present a simple and…”
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Molecular pathology - the key to precision oncology by Edsjö, Anders, Palmqvist, Richard, Haglund, Felix, Helenius, Gisela, Lindqvist, Oscar, Fagman, Henrik, Botling, Johan

“…Rapidly expanding knowledge of the molecular landscape of cancers has resulted in the implementation of an increasing number of specific therapies targeted at…”
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353 Protein expression for receptor activator of NFkB (RANK) and its ligand (RANKL) in non-small cell lung cancer (NSCLC) by D'Arcangelo, M, Ekman, S, Dougall, W, Branstetter, D, Bergqvist, M, Liv, P, Chan, D, Botling, J, Hirsch, F

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Long-term effects of surgical correction of adrenal hyperplasia and adenoma causing primary aldosteronism by Hennings, J., Andreasson, S., Botling, J., Hägg, A., Sundin, A., Hellman, P.

“…Purpose The purpose of this is to study long-time results of surgery for primary aldosteronism. Materials and methods Thirty patients operated on for primary…”
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Bone marrow fibrosis in childhood acute lymphoblastic leukemia correlates to biological factors, treatment response and outcome by Norén-Nyström, U, Roos, G, Bergh, A, Botling, J, Lönnerholm, G, Porwit, A, Heyman, M, Forestier, E

“…We retrospectively evaluated reticulin fiber density (RFD) in 166 diagnostic bone marrow (BM) biopsies and 62 biopsies obtained at treatment day 29 from…”
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Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance by DHAR, S, NYGREN, P, CSOKA, K, BOTLING, J, NILSSON, K, LARSSON, R

“…Differential drug response in a human cell line panel representing defined types of cytotoxic drug resistance was measured using the non-clonogenic…”
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Targeting MARCO and IL37R on Immunosuppressive Macrophages in Lung Cancer Blocks Regulatory T Cells and Supports Cytotoxic Lymphocyte Function by La Fleur, Linnéa, Botling, Johan, He, Fei, Pelicano, Catarina, Zhou, Chikai, He, Chenfei, Palano, Giorgia, Mezheyeuski, Artur, Micke, Patrick, Ravetch, Jeffrey V, Karlsson, Mikael C I, Sarhan, Dhifaf

“…The progression and metastatic capacity of solid tumors are strongly influenced by immune cells in the tumor microenvironment. In non-small cell lung cancer…”
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796 Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer by Sørlie, T, Muggerud, A.A, Hallett, M, Johnsen, H, Kleivi, K, Botling, J, Børresen-Dale, A.L, Wärnberg, F

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Distinct developmental pathways from blood monocytes generate human lung macrophage diversity by Evren, Elza, Ringqvist, Emma, Tripathi, Kumar Parijat, Sleiers, Natalie, Rives, Inés Có, Alisjahbana, Arlisa, Gao, Yu, Sarhan, Dhifaf, Halle, Tor, Sorini, Chiara, Lepzien, Rico, Marquardt, Nicole, Michaëlsson, Jakob, Smed-Sörensen, Anna, Botling, Johan, Karlsson, Mikael C.I., Villablanca, Eduardo J., Willinger, Tim

“…The study of human macrophages and their ontogeny is an important unresolved issue. Here, we use a humanized mouse model expressing human cytokines to dissect…”
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139P KRAS-G12C NSCLC linked to female sex and high risk of CNS metastasis: Real-world data from the National Swedish Lung Cancer Registry 2016-2019 by Isaksson, J., Berglund, A., Louie, K., Hamidian, A., Edsjö, A., Johansson, M., Hallqvist, A., Wagenius, G., Willén, L., Botling, J.

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Mutation patterns in a population-based non-small cell lung cancer cohort and prognostic impact of concomitant mutations in KRAS and TP53 or STK11 by La Fleur, Linnéa, Falk-Sörqvist, Elin, Smeds, Patrik, Berglund, Anders, Sundström, Magnus, Mattsson, Johanna SM, Brandén, Eva, Koyi, Hirsh, Isaksson, Johan, Brunnström, Hans, Nilsson, Mats, Micke, Patrick, Moens, Lotte, Botling, Johan

“…•No technical bias between fresh frozen and FFPE samples.•A high fraction of adenocarcinoma patients with activating KRAS mutations.•Mutations in TP53, STK11…”
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Biomarker Discovery in Non―Small Cell Lung Cancer: Integrating Gene Expression Profiling, Meta-analysis, and Tissue Microarray Validation by BOTLING, Johan, EDLUND, Karolina, KÖNIG, André, FERNANDES, Oswaldo, KARLSSON, Mats, HELENIUS, Gisela, KARLSSON, Christina, RAHNENFÜHRER, Jörg, HENGSTLER, Jan G, MICKE, Patrick, LOHR, Miriam, HELLWIG, Birte, HOLMBERG, Lars, LAMBE, Mats, BERGLUND, Anders, EKMAN, Simon, BERGQVIST, Michael, PONTEN, Fredrik

“…Global gene expression profiling has been widely used in lung cancer research to identify clinically relevant molecular subtypes as well as to predict…”
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Stromal FAP is an independent poor prognosis marker in non-small cell lung adenocarcinoma and associated with p53 mutation by Moreno-Ruiz, Pablo, Corvigno, Sara, te Grootenhuis, Nienke C., La Fleur, Linnéa, Backman, Max, Strell, Carina, Mezheyeuski, Artur, Hoelzlwimmer, Gabriele, Klein, Christian, Botling, Johan, Micke, Patrick, Östman, Arne

“…•High FAP stroma intensity is a poor prognosis marker in non-small cell lung cancer.•P53 mutation is positively associated with fibroblast stroma…”
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The prognostic relevance of tumour-infiltrating plasma cells and immunoglobulin kappa C indicates an important role of the humoral immune response in non-small cell lung cancer by Lohr, Miriam, Edlund, Karolina, Botling, Johan, Hammad, Seddik, Hellwig, Birte, Othman, Amnah, Berglund, Anders, Lambe, Mats, Holmberg, Lars, Ekman, Simon, Bergqvist, Michael, Pontén, Fredrik, Cadenas, Cristina, Marchan, Rosemarie, Hengstler, Jan G, Rahnenführer, Jörg, Micke, Patrick

“…Highlights ► IGKC gene and protein expression in human non-small cell lung cancer is associated with prognosis. ► IGKC is expressed in stroma-infiltrating…”
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Expression of scavenger receptor MARCO defines a targetable tumor‐associated macrophage subset in non‐small cell lung cancer by La Fleur, Linnéa, Boura, Vanessa F., Alexeyenko, Andrey, Berglund, Anders, Pontén, Victor, Mattsson, Johanna S.M., Djureinovic, Dijana, Persson, Johan, Brunnström, Hans, Isaksson, Johan, Brandén, Eva, Koyi, Hirsh, Micke, Patrick, Karlsson, Mikael C.I., Botling, Johan

“…Tumor‐associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti‐TAM…”
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Spatial immunophenotyping of the tumour microenvironment in non–small cell lung cancer by Backman, Max, Strell, Carina, Lindberg, Amanda, Mattsson, Johanna S.M., Elfving, Hedvig, Brunnström, Hans, O'Reilly, Aine, Bosic, Martina, Gulyas, Miklos, Isaksson, Johan, Botling, Johan, Kärre, Klas, Jirström, Karin, Lamberg, Kristina, Pontén, Fredrik, Leandersson, Karin, Mezheyeuski, Artur, Micke, Patrick

“…Immune cells in the tumour microenvironment are associated with prognosis and response to therapy. We aimed to comprehensively characterise the spatial immune…”
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