Search Results - "Bothwell, Mark"

Recent advances in understanding neurotrophin signaling by Bothwell, Mark

“…The nerve growth factor family of growth factors, collectively known as neurotrophins, are evolutionarily ancient regulators with an enormous range of…”
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Mechanisms and Medicines for Remyelination by Bothwell, Mark

“…Demyelination of central nervous system axons, associated with traumatic injury and demyelinating diseases such as multiple sclerosis, causes impaired neural…”
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Recent advances in understanding context-dependent mechanisms controlling neurotrophin signaling and function [version 1; peer review: 3 approved] by Bothwell, Mark

“…Complex mechanisms control the signaling of neurotrophins through p75 NTR and Trk receptors, allowing cellular responses that are highly context dependent,…”
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Alternative Theory of AD Pathogenesis: Membrane Delimitation of the Histone Acetyltransferase Tip60/Kat5 by Wiley, Jesse C, Young, Jessica E., Jayadev, Suman, Darvas, Martin, Swerdlow, Russell H, Wolfe, Michael S., Heath, Laura M, Gockley, Jake, Cary, Gregory A., Poehlman, William L., Ladiges, Warren, Carter, Gregory W, Bothwell, Mark A, Greenwood, Anna K, Mangravite, Lara M

“…Background For decades, mounting genetic and physiological data have pointed to the APP proteolysis as a seminal event in AD pathogenesis. This data has been…”
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Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers by Vilar, Marçal, Charalampopoulos, Ioannis, Kenchappa, Rajappa S., Simi, Anastasia, Karaca, Esra, Reversi, Alessandra, Choi, Soyoung, Bothwell, Mark, Mingarro, Ismael, Friedman, Wilma J., Schiavo, Giampietro, Bastiaens, Philippe I.H., Verveer, Peter J., Carter, Bruce D., Ibáñez, Carlos F.

“…Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Neurotrophins interact with dimers of the p75…”
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Conformational sampling of CMT-2D associated GlyRS mutations by Childers, Matthew Carter, Regnier, Michael, Bothwell, Mark, Smith, Alec S.T.

“…During protein synthesis, aminoacyl-tRNA synthetases covalently link amino acids with their cognate tRNAs. Amino acid mutations in glycyl-tRNA synthetase can…”
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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells by Wiley, Jesse C, Meabon, James S, Frankowski, Harald, Smith, Elise A, Schecterson, Leslayann C, Bothwell, Mark, Ladiges, Warren C

“…The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The pathological…”
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TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis by Schecterson, Leslayann C, Sanchez, Jason Tait, Rubel, Edwin W, Bothwell, Mark

“…The chick embryo (Gallus domesticus) is one of the most important model systems in vertebrate developmental biology. The development and function of its…”
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Editorial: Modeling neuromuscular diseases to determine molecular drivers of pathology and for drug discovery by Smith, Alec S. T., McCain, Megan L., Bothwell, Mark, Mack, David L.

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LIG Family Receptor Tyrosine Kinase-Associated Proteins Modulate Growth Factor Signals during Neural Development by Mandai, Kenji, Guo, Ting, St. Hillaire, Coryse, Meabon, James S., Kanning, Kevin C., Bothwell, Mark, Ginty, David D.

“…Genome-wide screens were performed to identify transmembrane proteins that mediate axonal growth, guidance and target field innervation of somatosensory…”
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Human Induced Pluripotent Stem Cell-Derived TDP-43 Mutant Neurons Exhibit Consistent Functional Phenotypes Across Multiple Gene Edited Lines Despite Transcriptomic and Splicing Discrepancies by Smith, Alec S T, Chun, Changho, Hesson, Jennifer, Mathieu, Julie, Valdmanis, Paul N, Mack, David L, Choi, Byung-Ok, Kim, Deok-Ho, Bothwell, Mark

“…Gene editing technologies hold great potential to enhance our ability to model inheritable neurodegenerative diseases. Specifically, engineering multiple…”
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Eph Receptors and Ephrins in the Developing Chick Cerebellum: Relationship to Sagittal Patterning and Granule Cell Migration by Karam, Sana D, Burrows, Robert C, Logan, Cairine, Koblar, Simon, Pasquale, Elena B, Bothwell, Mark

“…Spatiotemporal expression patterns of six members of the Eph gene family (EphA4, EphA3, EphB2, ephrin-B1, ephrin-A2, and ephrin-A5) were characterized…”
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Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs by Patterson, S L, Grover, L M, Schwartzkroin, P A, Bothwell, M

“…We report that stimulation inducing long-term potentiation (LTP) in the CA1 pyramidal cell layer of the hippocampus evokes significant increases in both BDNF…”
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Neurotrophin-3 Is Required for the Survival-Differentiation of Subsets of Developing Enteric Neurons by Chalazonitis, Alcmene, Pham, Tuan D, Rothman, Taube P, DiStefano, Peter S, Bothwell, Mark, Blair-Flynn, Janet, Tessarollo, Lino, Gershon, Michael D

“…Neurotrophin-3 (NT-3) promotes enteric neuronal development in vitro; nevertheless, an enteric nervous system (ENS) is present in mice lacking NT-3 or TrkC. We…”
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FGF2 Alters Expression of the Pyrophosphate/Phosphate Regulating Proteins, PC-1, ANK and TNAP, in the Calvarial Osteoblastic Cell Line, MC3T3E1(C4) by Hatch, Nan E., Nociti, Francisco, Swanson, Erica, Bothwell, Mark, Somerman, Martha

“…Fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling has been linked to the aberrant mineralization phenotype of craniosynostosis…”
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Intracellular Retention, Degradation, and Signaling of Glycosylation-deficient FGFR2 and Craniosynostosis Syndrome-associated FGFR2C278F by Hatch, Nan E., Hudson, Mark, Seto, Marianne L., Cunningham, Michael L., Bothwell, Mark

“…Fibroblast growth factors (FGFs) and their receptors (FGFRs) are known to play a critical role in a variety of fundamental processes, including wound healing,…”
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Neurotrophin receptors: Old friends with new partners by Schecterson, Leslayann C., Bothwell, Mark

“…Neurotrophins are important regulators of embryonic development and adult function of most populations of neurons in vertebrate nervous systems. This signaling…”
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Expression and structure of the human NGF receptor by Johnson, D, Lanahan, A, Buck, C R, Sehgal, A, Morgan, C, Mercer, E, Bothwell, M, Chao, M

“…The nucleotide sequence for the human nerve growth factor (NGF) receptor has been determined. The 3.8 kb receptor mRNA encodes a 427 amino acid protein…”
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Granule cells migrate within raphes in the developing cerebellum: An evolutionarily conserved morphogenic event by Karam, Sana D., Kim, Yun S., Bothwell, Mark

“…The early phase of granule cell migration in the developing chick cerebellum occurs within ribbons of cells moving through parasagittally arrayed gaps between…”
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Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system by von Bartheld, Christopher S, Byers, Margaret R, Williams, Reg, Bothwell, Mark

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